Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Robert P. Ricciardi"'
Autor:
Claire H. Mitchell, Robert P. Ricciardi, Chenyan Lin, Allen B. Reitz, Wennan Lu, Vivian S. Lee, Richard W. Scott, Hancheng Guan, Manunya Nuth, Michael H. Parker, John L. Kulp
Publikováno v:
Ocul Surf
Purpose Acyclovir is most commonly used for treating ocular Herpes Keratitis, a leading cause of infectious blindness. However, emerging resistance to Acyclovir resulting from mutations in the thymidine kinase gene of Herpes Simplex Virus −1 (HSV-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c825deb0a21a908dc4f003e0762f91
https://doi.org/10.1016/j.jtos.2020.11.001
https://doi.org/10.1016/j.jtos.2020.11.001
Autor:
Hancheng Guan, Manunya Nuth, Stuart N. Isaacs, Yuhong Xiao, Richard W. Scott, Michael H. Parker, Eric D. Strobel, John L. Kulp, Thomas R. Bailey, Allen B. Reitz, Robert P. Ricciardi
Publikováno v:
Antiviral research.
Molluscum contagiosum (MC) is an infectious disease that occurs only in humans with a tropism that is narrowly restricted to the outermost epidermal layer of the skin. Molluscum contagiosum virus (MCV) is the causative agent of MC which produces skin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5013366080027eb89748a1348647e06f
https://pubmed.ncbi.nlm.nih.gov/36603771
https://pubmed.ncbi.nlm.nih.gov/36603771
Autor:
Reyazul Islam, Ronald N. Harty, Ali Raza Ali, Margaret Mawson, Stephen J. Streatfield, Henry Daniell, David B. Weiner, Kenneth B. Margulies, Geetanjali Wakade, Michael C. Milone, Brian J. Green, Sheng Feng, Smruti K Nair, Jevon Graham-Wooten, Ronald G. Collman, Nardana Esmaeili, Robert P. Ricciardi, Ebony N. Gary, Selene Guadalupe Nunez Cruz, Ping Wang, Paul Kaznica, Prem Kumar Ganesan, Manunya Nuth, Ruben Montoya-Lopez, Ariel Shepley-McTaggart, Naila Shahid
Publikováno v:
Molecular Therapy
To advance a novel concept of debulking virus in the oral cavity, the primary site of viral replication, virus trapping proteins CTB-ACE2 were expressed in chloroplasts and clinical grade plant material was developed to meet FDA requirements. Chewing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e44e933b237a0325340b3c7dff7a893
https://pubmed.ncbi.nlm.nih.gov/34774754
https://pubmed.ncbi.nlm.nih.gov/34774754
Publikováno v:
Int J Oncol
Squamous cell carcinoma is the major form of malignancy that arises in head and neck cancer. The modest improvement in the 5-year survival rate underpins its complex etiology and provides the impetus for the discovery of new therapeutics. The present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7d84c27f8815ed466659244d63f7febe
https://pubmed.ncbi.nlm.nih.gov/35211767
https://pubmed.ncbi.nlm.nih.gov/35211767
Autor:
Stuart N. Isaacs, Robert P. Ricciardi, Yuhong Xiao, Allen B. Reitz, John L. Kulp, Manunya Nuth, Eric D. Strobel, Michael H. Parker, Hancheng Guan, Richard W. Scott
Publikováno v:
Antiviral Res
The smallpox virus (variola) remains a bioterrorism threat since a majority of the human population has never been vaccinated. In the event of an outbreak, at least two drugs against different targets of variola are critical to circumvent potential v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee8c7cc5653aaeaf664c126ed9bcf60
https://doi.org/10.1016/j.antiviral.2018.12.011
https://doi.org/10.1016/j.antiviral.2018.12.011
Autor:
Henry Daniell, Smruti K. Nair, Hancheng Guan, Yuwei Guo, Rachel J. Kulchar, Marcelo D.T. Torres, Md. Shahed-Al-Mahmud, Geetanjali Wakade, Yo-Min Liu, Andrew D. Marques, Jevon Graham-Wooten, Wan Zhou, Ping Wang, Sudheer K. Molugu, William R. de Araujo, Cesar de la Fuente-Nunez, Che Ma, William R. Short, Pablo Tebas, Kenneth B. Margulies, Frederic D. Bushman, Francis K. Mante, Robert P. Ricciardi, Ronald G. Collman, Mark S. Wolff
Publikováno v:
Biomaterials. 288:121671
Because oral transmission of SARS-CoV-2 is 3-5 orders of magnitude higher than nasal transmission, we investigated debulking of oral viruses using viral trap proteins (CTB-ACE2, FRIL) expressed in plant cells, delivered through the chewing gum. In om
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb8054f881b8b9cca5cf1814a78ad0a
https://doi.org/10.1016/j.biomaterials.2022.121671
https://doi.org/10.1016/j.biomaterials.2022.121671
Publikováno v:
BioTechniques, Vol 30, Iss 2, Pp 380-386 (2001)
We describe an approach using phage display to identify effectors (activators and repressors) of transcription based on the particular component of the general transcription machinery that they target. We refer to this approach as the reverse identif
Externí odkaz:
https://doaj.org/article/ff932e60234a4d1da9ec895120be30f6
Publikováno v:
Journal of Biological Chemistry. 291:27087-27097
Vaccinia virus (VACV) is a poxvirus, and the VACV D4 protein serves both as a uracil-DNA glycosylase and as an essential component required for processive DNA synthesis. The VACV A20 protein has no known catalytic function itself but associates with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0133ea4d5e599ca76ab9959244499c
https://doi.org/10.1074/jbc.m116.761908
https://doi.org/10.1074/jbc.m116.761908
Autor:
Debasish Chattopadhyay, Surajit Banerjee, Norbert Schormann, Manunya Nuth, Richard E. Gillilan, Robert P. Ricciardi, Natalia Zhukovskaya, Peter E. Prevelige, Gregory J. Bedwell
Publikováno v:
Protein Science. 25:2113-2131
Uracil-DNA glycosylases are ubiquitous enzymes, which play a key role repairing damages in DNA and in maintaining genomic integrity by catalyzing the first step in the base excision repair pathway. Within the superfamily of uracil-DNA glycosylases fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4840f0bfea86e5f14aa5930e3b989e95
https://doi.org/10.1002/pro.3058
https://doi.org/10.1002/pro.3058
Publikováno v:
Antiviral Research. 115:17-20
Feline herpes virus-1 (FHV-1) is ubiquitous in the cat population and is a major cause of blindness for which antiviral drugs, including acyclovir, are not completely effective. Recurrent infections, due to reactivation of latent FHV-1 residing in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3cd22eff6db0f2c42e25c693b987d3f
https://doi.org/10.1016/j.antiviral.2014.12.013
https://doi.org/10.1016/j.antiviral.2014.12.013