Zobrazeno 1 - 10
of 586
pro vyhledávání: '"Robert McKenna"'
Autor:
Shaheen Bibi, Gerald V. Minsavage, J. Figueiredo, Sujan Timilsina, Kayla Margin, Juliana Quay, Hannah Bendure, Elizabeth Ryerson, Cliff Calloway, Jacob Andring, Aastha Subedi, Robert McKenna, Paul Gulig, Erica M. Goss, Jason C. Hurlbert, Jeffrey B. Jones
Publikováno v:
Molecular Plant-Microbe Interactions, Vol 37, Iss 11, Pp 784-800 (2024)
Many phytopathogenic bacteria require a type III secretion system (TTSS) to activate effector-triggered immunity (ETI). We identified a calcium-binding protein, EfhXXfa, in the citrus pathogen Xanthomonas citri subsp. aurantifolii that does not requi
Externí odkaz:
https://doaj.org/article/0be00239cfaa489fad62e5a14a3eb7cc
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101377- (2024)
The application of adeno-associated virus (AAV) vectors in human gene therapies requires reproducible and homogeneous preparations for clinical efficacy and safety. For the AAV production process, often scalable affinity chromatography columns are ut
Externí odkaz:
https://doaj.org/article/031149bf4c274a369e897231d5c06b1f
Autor:
Sriram Aiyer, Philip R. Baldwin, Shi Min Tan, Zelin Shan, Juntaek Oh, Atousa Mehrani, Marianne E. Bowman, Gordon Louie, Dario Oliveira Passos, Selena Đorđević-Marquardt, Mario Mietzsch, Joshua A. Hull, Shuichi Hoshika, Benjamin A. Barad, Danielle A. Grotjahn, Robert McKenna, Mavis Agbandje-McKenna, Steven A. Benner, Joseph A. P. Noel, Dong Wang, Yong Zi Tan, Dmitry Lyumkis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Structural biology efforts using cryogenic electron microscopy are frequently stifled by specimens adopting “preferred orientations” on grids, leading to anisotropic map resolution and impeding structure determination. Tilting the specim
Externí odkaz:
https://doaj.org/article/769b229c79fd4c90939a615ca424d44d
Autor:
Lirong Li, Runkuan Qin, Yunbo Liu, Yu-Shan Tseng, Weihan Zhang, Lin Yu, Mario Mietzsch, Xinkai Zou, Haizhou Liu, Guangwen Lu, Hongbo Hu, Robert Mckenna, Jinliang Yang, Yuquan Wei, Mavis Agbandje-Mckenna, Jiankun Hu, Lin Yang
Publikováno v:
PLoS Pathogens, Vol 20, Iss 6, p e1012260 (2024)
Adeno-associated virus (AAV) serotypes from primates are being developed and clinically used as vectors for human gene therapy. However, the evolutionary mechanism of AAV variants is far from being understood, except that genetic recombination plays
Externí odkaz:
https://doaj.org/article/359a3a31d4c442b8b1f94897be994549
Autor:
Mitchell Gulkis, Mengxiao Luo, Paul Chipman, Mario Mietzsch, Maria Söderlund-Venermo, Antonette Bennett, Robert McKenna
Publikováno v:
Viruses, Vol 16, Iss 8, p 1258 (2024)
Bufaviruses (BuV) are members of the Parvoviridae of the Protoparvovirus genus. They are non-enveloped, T = 1 icosahedral ssDNA viruses isolated from patients exhibiting acute diarrhea. The lack of treatment options and a limited understanding of the
Externí odkaz:
https://doaj.org/article/81dd140e5ccc4026aa0b5dc3c32620ab
Autor:
Mario Mietzsch, Shweta Kailasan, Antonette Bennett, Paul Chipman, Bentley Fane, Juha T. Huiskonen, Ian N. Clarke, Robert McKenna
Publikováno v:
Viruses, Vol 16, Iss 7, p 1103 (2024)
Spiroplasma virus 4 (SpV4) is a bacteriophage of the Microviridae, which packages circular ssDNA within non-enveloped T = 1 icosahedral capsids. It infects spiroplasmas, which are known pathogens of honeybees. Here, the structure of the SpV4 virion i
Externí odkaz:
https://doaj.org/article/d837cfe946374f07a31dec158ee1e2b4
Autor:
Cindy Y. Kok, Shinya Tsurusaki, Marti Cabanes-Creus, Sindhu Igoor, Renuka Rao, Rhys Skelton, Sophia H.Y. Liao, Samantha L. Ginn, Maddison Knight, Suzanne Scott, Mario Mietzsch, Rebecca Fitzsimmons, Jessica Miller, Tamer M.A. Mohamed, Robert McKenna, James J.H. Chong, Adam P. Hill, James E. Hudson, Ian E. Alexander, Leszek Lisowski, Eddy Kizana
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 459-473 (2023)
Recombinant adeno-associated viruses (rAAVs) have emerged as one of the most promising gene therapy vectors that have been successfully used in pre-clinical models of heart disease. However, this has not translated well to humans due to species diffe
Externí odkaz:
https://doaj.org/article/0a04499d5cb345478b523f2075186f26
Autor:
Judit J. Pénzes, Hanh T. Pham, Paul Chipman, Emmanuel W. Smith, Robert McKenna, Peter Tijssen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Parvoviruses (family Parvoviridae) are currently defined by a linear monopartite ssDNA genome, T = 1 icosahedral capsids, and distinct structural (VP) and non-structural (NS) protein expression cassettes within their genome. We report the di
Externí odkaz:
https://doaj.org/article/be16f5c7d95a407baa1a3f19a38551cd
Autor:
Mario Mietzsch, Weijing Liu, Ke Ma, Antonette Bennett, Austin R. Nelson, Keely Gliwa, Paul Chipman, Xiaofeng Fu, Shane Bechler, Robert McKenna, Rosa Viner
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 460-472 (2023)
Adeno-associated viruses (AAVs) are non-enveloped ssDNA icosahedral T = 1 viruses used as vectors for clinical gene delivery. Currently, there are over 200 AAV-related clinical trials and six approved biologics on the market. As such new analytical m
Externí odkaz:
https://doaj.org/article/cc80c4e4947749aab583ab6959e31b24
Autor:
Seung Jin Jang, Natalie Atyeo, Mario Mietzsch, Min Y. Chae, Robert McKenna, Zsolt Toth, Bernadett Papp
Publikováno v:
Viruses, Vol 16, Iss 6, p 846 (2024)
The viral interferon regulatory factors (vIRFs) of KSHV are known to dysregulate cell signaling pathways to promote viral oncogenesis and to block antiviral immune responses to facilitate infection. However, it remains unknown to what extent each vIR
Externí odkaz:
https://doaj.org/article/0c0258e391ec498b8dde97ebc170c2b3