Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Robert J. Mycka"'
Autor:
Omar W. Steward, Robert J. Mycka, William T. Eckenhoff, Nathan Z. Barefoot, Fraser F. Fleming
Publikováno v:
Tetrahedron. 69:366-376
Deprotonating γ- and δ-hydroxynitriles with i-PrMgCl allows highly diastereoselective alkylations controlled by the asymmetry of the remote carbinol stereocenter. Mechanistic experiments are consistent with γ-hydroxynitriles alkylating via a chela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c4bc1bccd8deccd75e77b19b21e6c2b
https://doi.org/10.1016/j.tet.2012.10.016
https://doi.org/10.1016/j.tet.2012.10.016
Autor:
Johannes Heppekausen, Robert J. Mycka, Sebastian Bernhardt, Paul Knochel, Stéphanie Duez, Fraser F. Fleming
Publikováno v:
The Journal of Organic Chemistry. 77:7671-7676
Deprotonating substituted cyclohexanecarbonitriles with TMPZnCl·LiCl affords zincated nitriles that diastereoselectively couple with aryl bromides in the presence of catalytic Pd(OAc)(2) and S-Phos. Steric and electronic effects influence the diaste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a378cb10d9d902f6aa8513c6cb2c06e9
https://doi.org/10.1021/jo301127n
https://doi.org/10.1021/jo301127n
Publikováno v:
Organic Letters. 9:4507-4509
Sequential addition of i-PrMgCl and BuLi to sp3 hybridized iodoalcohols triggers a facile iodine-metal exchange. Intercepting the resulting cyclic Grignard reagents with a slight excess of an electrophile leads to a diverse range of substituted alcoh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea65aa0abdf4fbb8678b61e4b95ac913
https://doi.org/10.1021/ol701947y
https://doi.org/10.1021/ol701947y
ChemInform Abstract: γ- and δ-Hydroxynitriles: Diastereoselective Electrophile-Dependent Alkylations
Autor:
Omar W. Steward, Nathan Z. Barefoot, Robert J. Mycka, Fraser F. Fleming, William T. Eckenhoff
Publikováno v:
ChemInform. 44
Deprotonating γ- and δ-hydroxynitriles with i-PrMgCl allows highly diastereoselective alkylations controlled by the asymmetry of the remote carbinol stereocenter. Mechanistic experiments are consistent with γ-hydroxynitriles alkylating via a chela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a522a26f090b7e76cb31e003cfff052d
https://doi.org/10.1002/chin.201322049
https://doi.org/10.1002/chin.201322049
Publikováno v:
ChemInform. 41
The dependence of the diastereoselectivity of the reaction of the starting γ-hydroxynitriles on the nature of the electrophiles is investigated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d9f66f415f3bd6dcbb071cc84ab7513
https://doi.org/10.1002/chin.201046091
https://doi.org/10.1002/chin.201046091
Publikováno v:
Organic letters. 12(13)
Quaternary centers are efficiently installed in chelation-controlled alkylations of acyclic hydroxynitriles. Intriguingly, the stereoselectivity is determined by the nature of the electrophile and the structure of the Grignard used for the deprotonat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea57f501990d25fef5cc60b554e52d9
https://pubmed.ncbi.nlm.nih.gov/20524645
https://pubmed.ncbi.nlm.nih.gov/20524645
Publikováno v:
ChemInform. 39
Sequential addition of i-PrMgCl and BuLi to sp3 hybridized iodoalcohols triggers a facile iodine−metal exchange. Intercepting the resulting cyclic Grignard reagents with a slight excess of an electrophile leads to a diverse range of substituted alc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a8011ea300e25ccbea09df607e096e1
https://doi.org/10.1002/chin.200814058
https://doi.org/10.1002/chin.200814058
Publikováno v:
Organic Letters; Oct2007, Vol. 9 Issue 22, p4507-4509, 3p
Publikováno v:
Organic Letters; Nov2010, Vol. 12 Issue 21, p5084-5084, 1p