Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Robert Hett"'
Autor:
Stefan Canzar, Vigo Heissmeyer, Nicholas B. Angstman, Mark Helm, Aloys Schepers, Franziska Weichmann, Kaouthar Slama, Regina Feederle, Julian König, Robert Hett, Gunter Meister, Florian D. Hastert, M. Cristina Cardoso, Taku Ito-Kureha, Stefan Hüttelmaier, Andrew Flatley, Christoph Dieterich
Publikováno v:
RNA
Chemical modifications are found on almost all RNAs and affect their coding and noncoding functions. The identification of m6A on mRNA and its important role in gene regulation stimulated the field to investigate whether additional modifications are
Publikováno v:
Liebigs Annalen. 1996:189-200
An efficient, highly regio- and enantioselective methodology for the synthesis of α-silyl aldehydes and ketones 2 and 6 using two different procedures was developed. Direct α-silylation of the azaenolates derived from SAMP/RAMP hydrazones 3 with va
Publikováno v:
Angewandte Chemie International Edition. 43:5933-5936
Publikováno v:
Tetrahedron: Asymmetry. 14:3487-3493
A convergent total synthesis of enantiomerically-pure (2 R ,4 S ,2′ S ,3′ R )-hydroxyitraconazole 1b is described. The left dioxolane portion of the molecule was prepared in good yield by the conversion of ( S )- 10 to the corresponding enantiome
Publikováno v:
Organic Process Research & Development. 6:855-862
The development and large-scale implementation of a novel technology utilizing polymorphic interconversion and crystalline intermediate formation of (R,R)-formoterol l-tartrate ((R,R)-FmTA, 1) as a...
Publikováno v:
Organic Process Research & Development. 4:567-570
In the synthesis of the β2-adrenoceptor agonist (R,R)-formterol, a key step in the synthesis was the development of a highly chemoselective reduction of (1R)-2-bromo-1-[3-nitro-4-(phenylmethoxy)phenyl]ethan-1-ol to give (1R)-1-[3-amino-4-(phenylmeth
Autor:
Donald W. Kessler, Stephen A. Wald, Amy M. Kuhn, Gerald J. Tanoury, Chris H. Senanayake, Robert Hett
Publikováno v:
Tetrahedron Letters. 39:6845-6848
A palladium-catalyzed amination of triazolone 3 by piperazine 2 was used as the key step in an efficient synthesis of highly enantiomerically-pure hydroxyitraconazole isomers. Compound 2 (>99%ee) was prepared by reaction of an achiral phenol precurso
Publikováno v:
Tetrahedron Letters. 39:1705-1708
Several conformationally constrained oxazaborolidine catalysts have been evaluated in the reduction of ketone 1. Readily accessible (1R, 2S) 1-amino-2-tetralol (BH) derived oxazaborolidine catalyst (6b) proves to be the most effective and practica
Publikováno v:
Tetrahedron Letters. 38:7839-7842
The first stereoselective synthesis of cis , syn -hydroxyitraconazole isomers via a tricomponent coupling strategy is described. The isomers are prepared from two chiral subunits and connected via an achiral linker. A highly stereoselective route to
Publikováno v:
Tetrahedron Letters. 38:1125-1128
Enantioselective syntheses of all four stereoisomers of formoterol are accomplished using asymmetric catalytic borane reductions with chiral oxazaborolidines as reducing agents.