Zobrazeno 1 - 10
of 224
pro vyhledávání: '"Robert Farinotti"'
Autor:
Aline Milane, Lionel Tortolano, Christine Fernandez, Gilbert Bensimon, Vincent Meininger, Robert Farinotti
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 12, Iss 2 (2009)
PURPOSE: amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by the loss of motorneurons. The only drug approved is riluzole. Minocycline is an antibiotic with numerous neuroprotective properties. riluzole and minocycline
Externí odkaz:
https://doaj.org/article/1bddbc1ee9184f68be59d4f31735e7aa
Autor:
Sarah Vautier, Aline Milane, Christine Fernandez, Helene Chacun, Lucette Lacomblez, Robert Farinotti
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 12, Iss 2 (2009)
Purpose: MPTP-induced dopaminergic degeneration is an experimental model commonly used to explore Parkinson’s disease. Cerebral drug transport by ABC transporters in MPTP models has never been reported. Methods: We have investigated the transport o
Externí odkaz:
https://doaj.org/article/aaa3ac3a93c24b359f2f68f8ac206e1b
Autor:
Pierre-Francois Ceccaldi, Laurent Gavard, Laurent Mandelbrot, Elisabeth Rey, Robert Farinotti, Jean-Marc Treluyer, Sophie Gil
Publikováno v:
Obstetrics and Gynecology International, Vol 2009 (2009)
Aims. To study the influence of P-glycoprotein (P-glycoprotein, ABCB1, MDR1) function on placental transfer of lopinavir with ritonavir at different albumin concentrations. Methods. Cotyledons were perfused with lopinavir, ritonavir, and the internal
Externí odkaz:
https://doaj.org/article/59e830224d454df09e43b9aed49009ad
Autor:
Alexandre Carpentier, Ahmed Idbaih, Charlotte Schmitt, Camille Levasseur, Lauriane Goldwirt, Robert Farinotti, Aline Milane, Kevin Beccaria, Christine Fernandez, Marianne Labussière
Publikováno v:
Journal of Neuro-Oncology. 122:273-281
Glioblastoma (GBM) is the most common primary malignant brain tumour in adults. Prognosis of GBM patients is poor with median overall survival around 15 months. Temozolomide is the chemotherapeutic agent used in the standard of care of newly diagnose
Autor:
Valérie Cailliez, Raphaël Saffroy, Asma Mhiri, Laurence Bonhomme-Faivre, Gaëlle Noé, Mahamadou Tandia, Bernard Paule, Robert Farinotti
Publikováno v:
Cancer chemotherapy and pharmacology. 79(4)
We studied the relation between the polymorphism of P-glycoprotein (P-gp) and of breast cancer resistance protein (BCRP), encoded by ABCB1 and ABCG2 genes, respectively, and the pharmacokinetic variability and clinical response during the treatment w
Autor:
Fanchon Bourasset, Agnès Dodacki, Hélène Chacun, Beatrice Bedussi, Cédric Yapo, Tuan Minh Do, Stéphanie Chasseigneaux, Robert Farinotti, Jean-Michel Scherrmann
Publikováno v:
Journal of Alzheimer's Disease. 36:555-561
The influx of amyloid-β peptide (Aβ) across the blood-brain barrier is partly mediated by the receptor for advanced glycation end products (RAGE). But other transporters, like Oatp (organic anion transporter polypeptide, SLC21) transporters, could
Publikováno v:
Biomedical Chromatography. 27:889-893
A sensitive and accurate liquid chromatography method with mass spectrometry detection was developed and validated for the quantification of temozolomide in mouse plasma and brain. Theophyllin was used as the internal standard. A single-step protein
Autor:
Lauriane Goldwirt, Shaida Varnous, Florian Lemaitre, Saïk Urien, Robert Farinotti, Christine Fernandez, Marie Antignac, Elodie Bezian
Publikováno v:
Therapeutic Drug Monitoring. 34:686-694
BACKGROUND The aim of this study was, using routine drug monitoring data, to identify patient characteristics that may influence everolimus (EVE) pharmacokinetic parameters and to develop a population pharmacokinetic model to predict EVE whole blood
Publikováno v:
European Journal of Pharmaceutical Sciences. 46:484-491
P-glycoprotein belongs to the ATP binding cassette transporters, responsible for the multidrug resistance of cancer cells. These transporters efflux hydrophobic drugs outside cells and decrease their therapeutic efficacy. The aim of this study was to
Autor:
François Roullet-Renoleau, Noël Zahr, Marie Antignac, Christine Fernandez, Florian Lemaitre, Robert Farinotti
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 66:278-281
A reliable ultra high performance liquid chromatography tandem mass spectrometry method has been developed for the determination of everolimus in human peripheral blood mononuclear cells (PBMCs). Protein precipitation was used for sample preparation.