Výsledky vyhledávání - "Robert C. Brasch"

Evaluation of a Novel Macromolecular Cascade-Polymer Contrast Medium for Dynamic Contrast-Enhanced MRI Monitoring of Antiangiogenic Bevacizumab Therapy in a Human Melanoma Model

Autor: Bundit Chaopathomkul, V Rogut, David M. Shames, Clemens C. Cyran, Michael F. Wendland, Robert C. Brasch, Yanjun Fu

Publikováno v: Academic radiology, vol 20, iss 10

Rationale and objectivesTo assess the applicability of a novel macromolecular polyethylene glycol (PEG)-core gadolinium contrast agent for monitoring early antiangiogenic effects of bevacizumab using dynamic contrast-enhanced (DCE) magnetic resonance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df6e02ae1583a7e790727326633c437
https://doi.org/10.1016/j.acra.2013.07.010

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Evaluation of imatinib mesylate as a possible treatment for nephrogenic systemic fibrosis in a rat model

Autor: Robert C. Brasch, Thomas A. Hope, Yanjun Fu, Philip E. LeBoit, Whitney A. High

Publikováno v: Magnetic Resonance Imaging. 31:139-144

The purpose of the study was to evaluate the efficacy of imatinib mesylate in the treatment of nephrogenic systemic fibrosis (NSF) in a rat model administered high-dose gadodiamide, erythropoietin (Epo) and intravenous iron (IV iron).The local commit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2884ed5f9b8326de0b3cc41f3238c096
https://doi.org/10.1016/j.mri.2012.06.027

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Gadolinium Accumulation and Fibrosis in the Liver after Administration of Gadoxetate Disodium in a Rat Model of Active Hepatic Fibrosis

Autor: Aliya Qayyum, Amanda Doherty, Rizwan Aslam, Robert C. Brasch, Thomas A. Hope, Yanjun Fu

Publikováno v: Radiology. 264:423-427

To evaluate the effect of gadoxetate disodium on fibrosis in a rat model of active hepatic fibrosis.The local committee for animal research approved this study. Hepatic fibrosis was induced during 12 weeks of intraperitoneal injection of carbon tetra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92bb40ba764cafc253f8af0b0525f970
https://doi.org/10.1148/radiol.12112453

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Permeability to macromolecular contrast media quantified by dynamic MRI correlates with tumor tissue assays of vascular endothelial growth factor (VEGF)

Autor: Yanjun Fu, Barbara Sennino, Donald M. McDonald, V Rogut, Clemens C. Cyran, Bundit Chaopathomkul, Michael F. Wendland, Robert C. Brasch, David M. Shames, Hans-Juergen Raatschen

Publikováno v: European Journal of Radiology. 81:891-896

Purpose To correlate dynamic MRI assays of macromolecular endothelial permeability with microscopic area–density measurements of vascular endothelial growth factor (VEGF) in tumors. Methods and material This study compared tumor xenografts from two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634d189f1cb4767af3d652cdf64e6a7f
https://doi.org/10.1016/j.ejrad.2011.07.016

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Nephrogenic Systemic Fibrosis in Rats Treated with Erythropoietin and Intravenous Iron

Autor: Bundit Chaopathomkul, V Rogut, Thomas A. Hope, Robert C. Brasch, Whitney A. High, Robert J. Herfkens, Philip E. LeBoit

Publikováno v: Radiology. 253:390-398

To use a rat model for nephrogenic systemic fibrosis (NSF) that was administered high-dose gadodiamide to determine whether the co-administration of erythropoietin (Epo) and intravenous iron potentiated development of skin lesions that are thought to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8387790ef57f2406a15576582a952d69
https://doi.org/10.1148/radiol.2532090580

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Einfluss der mittels MRT bestimmten mikrovaskulären Permeabilität auf die Akkumulation von Vinorelbine in experimentellen Xenograft-Tumoren

Autor: V Rogut, H. J. Raatschen, Karl-Jürgen Wolf, Barbara Sennino, Yanjun Fu, Gerhard H. Simon, Robert C. Brasch

Publikováno v: RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren. 182:133-139

To determine the effects of MRI-assayed vascular leakiness on the delivery of macromolecular therapeutics to tumors.MDA-MB 435 tumors, subcutaneously implanted into nude rats were treated with a single dose of bevacizumab at levels of 0.1 mg (n = 5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90a988fdd50f696ea6ba11a0549cd7c6
https://doi.org/10.1055/s-0028-1109753

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Correlative dynamic contrast MRI and microscopic assessments of tumor vascularity in RIP-tag2 transgenic mice

Autor: Donald M. McDonald, Barbara Sennino, Weon-Kyoo You, Hans-Juergen Raatschen, David M. Shames, Michael F. Wendland, Yanjun Fu, Robert C. Brasch

Publikováno v: Magnetic Resonance in Medicine. 62:616-625

The purpose of this study was to define the feasibility of dynamic contrast-enhanced magnetic resonance imaging (MRI) to estimate the vascular density and leakiness of spontaneous islet cell tumors in RIP-Tag2 transgenic mice. Dynamic T1-weighted spo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620cb283918fc1b51b207b5a891f5952
https://doi.org/10.1002/mrm.22040

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In Vivo Monitoring of Angiogenesis Inhibitory Treatment Effects by Dynamic Contrast-Enhanced Computed Tomography in a Xenograft Tumor Model

Autor: Robert C. Brasch, Benjamin M. Yeh, Hans-Juergen Raatschen, Yanjun Fu, David M. Shames, Hubertus Pietsch

Publikováno v: Investigative Radiology. 44:265-270

Rationale and Objectives: To evaluate the potential of dynamic CT enhanced by iohexol or a novel macromolecular contrast agent, PEG 12ooo -Gen4-triiodo, to monitor microvascular changes in tumors treated with the angiogenesis inhibitor bevacizumab. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b259b535c7fbf60b9e2a5c2b55435a
https://doi.org/10.1097/rli.0b013e31819f1b60

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Vascular Permeability during Antiangiogenesis Treatment: MR Imaging Assay Results as Biomarker for Subsequent Tumor Growth in Rats

Autor: David M. Shames, Michael F. Wendland, Robert C. Brasch, Gerhard H. Simon, Hans-Juergen Raatschen, Yanjun Fu, Donald M. McDonald, Barbara Sennino

Publikováno v: Radiology. 247:391-399

Purpose: To prospectively evaluate in rats the acute change in tumor vascular leakiness (KPS) assayed at magnetic resonance (MR) imaging after a single dose of the angiogenesis inhibitor bevacizumab as a predictive biomarker of tumor growth response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0464af65d7d7aed08c6ea94896378db6
https://doi.org/10.1148/radiol.2472070363

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New macromolecular polymeric MRI contrast agents for application in the differentiation of cancer from benign soft tissues

Autor: Michael F. Wendland, V Rogut, Clemens C. Cyran, David M. Shames, Bundit Chaopathomkul, Hans-Juergen Raatschen, Benjamin M. Yeh, Yanjun Fu, Robert C. Brasch

Publikováno v: Journal of Magnetic Resonance Imaging. 27:581-589

Purpose To compare three new macromolecular polyethylene glycol (PEG) -core dendrimeric gadolinium(Gd)-based MRI contrast agents for their applicability in quantitative assays of endothelial leakiness and tissue vascular density for the differentiati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f03328f1e23b063b17d968fa85e94c55
https://doi.org/10.1002/jmri.21245

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