Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Robert A. Fecik"'
Autor:
Greg J. Dodge, Janet L. Smith, William D. Fiers, Courtney C. Aldrich, Robert A. Fecik, Yang Li
Publikováno v:
Chemical Science. 6:5027-5033
Polyketide synthase (PKS) β-processing domains are responsible for much of the stereochemical complexity of polyketide natural products. Although the importance of β-processing domains has been well noted and significantly explored, key stereochemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d2db8003915ec7f7c5fcc42823888b2
https://doi.org/10.1039/c5sc01505g
https://doi.org/10.1039/c5sc01505g
Autor:
Janet L. Smith, William D. Fiers, Robert A. Fecik, Yang Li, Steffen M. Bernard, Courtney C. Aldrich
Publikováno v:
ACS Chemical Biology
Among natural product families, polyketides have shown the most promise for combinatorial biosynthesis of natural product-like libraries. Though recent research in the area has provided many mechanistic revelations, a basic-level understanding of kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8261bb3caed62ddd3d41289d946cd49
http://europepmc.org/articles/PMC4273979
http://europepmc.org/articles/PMC4273979
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:5939-5942
A general strategy to enzymatically label acyl carrier proteins (ACPs) of polyketide synthases has been developed. Incorporation of a chloromethyl ketone or vinyl ketone moiety into polyketide chain elongation intermediate mimics allows for the synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be0cb7deb72049d551598c3cf87a3f40
https://doi.org/10.1016/j.bmcl.2010.05.089
https://doi.org/10.1016/j.bmcl.2010.05.089
Publikováno v:
ChemBioChem. 9:1609-1616
Mutasynthesis in pikromycin PKS: The amenability of pikromycin polyketide synthase to mutational biosynthesis has been demonstrated. A natural triketide and its analogues, activated as N-acetyl-cysteamine thioesters, were synthesized and fed to a pik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca97f9f2cb4acf5caf308cbbc35ac937
https://doi.org/10.1002/cbic.200700635
https://doi.org/10.1002/cbic.200700635
Autor:
Robert A. Fecik, Janet L. Smith, William D. Fiers, Yang Li, Courtney C. Aldrich, Greg J. Dodge
Metabolic engineering of polyketide synthase (PKS) pathways represents a promising approach to natural products discovery. The dehydratase (DH) domains of PKSs, which generate an α,β-unsaturated bond through a dehydration reaction, have been poorly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da8b490bfe64e99f606e913ddd23a25
https://europepmc.org/articles/PMC4624270/
https://europepmc.org/articles/PMC4624270/
Publikováno v:
Natural product reports. 32(5)
Covering: 2000 to 2014 Since their first report in 2000, tubulysins have sparked great interest for development as anti-cancer agents due to their exceptionally potent antiproliferative activity. Progress in the discovery and development of tubulysin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d659023d83a6fd577ed027b35703c96
https://pubmed.ncbi.nlm.nih.gov/25677951
https://pubmed.ncbi.nlm.nih.gov/25677951
Autor:
Jeffrey D. Kittendorf, Robert A. Fecik, John William Giraldes, Janet L. Smith, David H. Sherman, David L. Akey
Publikováno v:
Nature Chemical Biology. 2:531-536
Polyketides are a diverse class of natural products having important clinical properties, including antibiotic, immunosuppressive and anticancer activities. They are biosynthesized by polyketide synthases (PKSs), which are modular, multienzyme comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33ae38a568e568d331a7744594b1bca6
https://doi.org/10.1038/nchembio822
https://doi.org/10.1038/nchembio822
Autor:
Robert A. Fecik, Janet L. Smith, David H. Sherman, Jeffrey D. Kittendorf, John William Giraldes, David L. Akey
Publikováno v:
Nature Chemical Biology. 2:537-542
Polyketides are a class of biologically active microbial and plant-derived metabolites that possess a high degree of structural and functional diversity and include many human therapeutics, among them anti-infective and anti-cancer drugs, growth prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff7421c04abcc14b1201ebaab48bbf5
https://doi.org/10.1038/nchembio824
https://doi.org/10.1038/nchembio824
Publikováno v:
The Journal of Organic Chemistry. 70:7267-7272
[reaction: see text] An improved synthesis of (3S)-3-dihydronarbonolide is reported that constitutes a formal total synthesis of the 14-membered macrolactone antibiotic narbonolide. The key step was an intramolecular Nozaki-Hiyama-Kishi coupling to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a70da0d84356194ec6b93a97fe1096
https://doi.org/10.1021/jo050924a
https://doi.org/10.1021/jo050924a
Autor:
Lester A. Mitscher, Linus L. Shen, Pratik Devasthale, Segaran P. Pillai, Ali Keschavarz-Shokri, Robert A. Fecik
Publikováno v:
Journal of Medicinal Chemistry. 48:1229-1236
In pursuit of an apparent literature anomaly, S- and R-6-methyl-6,7-dihydro-2H-benzo[a]quinolizin-2-one-3-carboxylic acids (12 and 22) were synthesized by an unambiguous route from optically active norephedrines, and their antibacterial potencies wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4661acb42207e341a2b7927357e95286
https://doi.org/10.1021/jm0401356
https://doi.org/10.1021/jm0401356