Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Robert B. Rawson"'
Publikováno v:
PLoS Pathogens, Vol 2, Iss 10, p e102 (2006)
During infection by diverse viral families, RNA replication occurs on the surface of virally induced cytoplasmic membranes of cellular origin. How this process is regulated, and which cellular factors are required, has been unclear. Moreover, the hos
Externí odkaz:
https://doaj.org/article/4bd2af6753844885ae9863e7eb970ffc
Autor:
Robert B. Rawson
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1828(12):2801-2807
The site-2 protease (S2P) is an unusually-hydrophobic integral membrane protease. It cleaves its substrates, which are membrane-bound transcription factors, within membrane-spanning helices. Although structural information for S2P from animals is lac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18be48337d3958570af09a85ca164735
Publikováno v:
Genetics. 185:189-198
The escort factor Scap is essential in mammalian cells for regulated activation of sterol regulatory element binding proteins (SREBPs). SREBPs are membrane-bound transcription factors. Cells lacking Scap cannot activate SREBP. They are therefore defi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::797afec9cb36570f6b6fbb37e99fe1bd
https://doi.org/10.1534/genetics.110.114975
https://doi.org/10.1534/genetics.110.114975
Publikováno v:
Genetics. 181:119-128
Sterol regulatory element binding protein (SREBP) is a major transcriptional regulator of lipid metabolism. Nuclear Drosophila SREBP (dSREBP) is essential for larval development in Drosophila melanogaster but dispensable in adults. dSREBP− larvae d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c04b3e17c4478d4391c71bc3e94b98
https://doi.org/10.1534/genetics.108.093450
https://doi.org/10.1534/genetics.108.093450
Autor:
Robert B. Rawson
Publikováno v:
Genes & Development. 22:1561-1566
Rhomboid intramembrane proteases occur throughout the kingdoms of life. In this issue of Genes & Development, Baxt and colleagues (pp. 1636–1646) report that the single proteolytic rhomboid (EhROM1) from Entamoeba histolytica cleaves cell surface g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2ec1a2d36c84e60edeab3732c29d203
https://doi.org/10.1101/gad.1686808
https://doi.org/10.1101/gad.1686808
Publikováno v:
Cell Metabolism. 3:439-448
SummarySREBPs are membrane bound transcription factors that are crucial for normal lipid synthesis in animal cells. Here, we show that Drosophila lacking dSREBP die before the third larval instar. Mutant larvae exhibit pronounced growth defects prior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a0cbabd0d3a8b829d6a716ff455881f
https://doi.org/10.1016/j.cmet.2006.04.011
https://doi.org/10.1016/j.cmet.2006.04.011
Autor:
Robert B. Rawson
Publikováno v:
Nature Reviews Molecular Cell Biology. 4:631-640
Animal cells coordinate lipid homeostasis by end-product feedback regulation of transcription. The control occurs through the proteolytic release of transcriptionally active sterol regulatory element binding proteins (SREBPs) from intracellular membr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952b8989989f311d1ab0d93df55f9967
https://doi.org/10.1038/nrm1174
https://doi.org/10.1038/nrm1174
Autor:
Michael S. Brown, Irina Y. Dobrosotskaya, Adam C. Seegmiller, Joseph L. Goldstein, Robert B. Rawson
Publikováno v:
Science. 296:879-883
Animal cells exert exquisite control over the physical and chemical properties of their membranes, but the mechanisms are obscure. We show that phosphatidylethanolamine, the major phospholipid in Drosophila , controls the release of sterol regulatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703f4223e631cfcb7410e7073c9844f5
https://doi.org/10.1126/science.1071124
https://doi.org/10.1126/science.1071124
Autor:
Michael S. Brown, Y. K. Ho, Irina Y. Dobrosotskaya, Joseph L. Goldstein, Robert B. Rawson, Adam C. Seegmiller
Publikováno v:
Developmental Cell. 2(2):229-238
In mammals, synthesis of cholesterol and unsaturated fatty acids is controlled by SREBPs, a family of membrane-bound transcription factors. Here, we show that the Drosophila genome encodes all components of the SREBP pathway, including a single SREBP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e6d75eaf10184c749a0a376938dee2
Autor:
Utpal P. Davé, Ryutaro Komuro, Michael S. Brown, Xi Chen, Ron Prywes, Joseph L. Goldstein, Jin Ye, Robert B. Rawson
Publikováno v:
Molecular Cell. 6(6):1355-1364
ATF6 is a membrane-bound transcription factor that activates genes in the endoplasmic reticulum (ER) stress response. When unfolded proteins accumulate in the ER, ATF6 is cleaved to release its cytoplasmic domain, which enters the nucleus. Here, we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317a9ddf2fc8e1c17a7cc90b48f12809