Zobrazeno 1 - 10
of 338
pro vyhledávání: '"Robert, Sebra"'
Autor:
Sanutha Shetty, Samuel J. Duesman, Sanil Patel, Pacific Huynh, Pamela Toh, Sanjana Shroff, Anika Das, Disha Chowhan, Benjamin Keller, Johana Alvarez, Rachel Fisher-Foye, Robert Sebra, Kristin Beaumont, Cameron S. McAlpine, Prashant Rajbhandari, Abha K. Rajbhandari
Publikováno v:
Biology of Sex Differences, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Background Scientific evidence highlights the influence of biological sex on the relationship between stress and metabolic dysfunctions. However, there is limited understanding of how diet and stress concurrently contribute to metabolic dysr
Externí odkaz:
https://doaj.org/article/779adfb4b2184858af3a063319086850
Autor:
Li Wang, Sudeh Izadmehr, John P. Sfakianos, Michelle Tran, Kristin G. Beaumont, Rachel Brody, Carlos Cordon-Cardo, Amir Horowitz, Robert Sebra, William K. Oh, Nina Bhardwaj, Matthew D. Galsky, Jun Zhu
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109928- (2024)
Summary: Interactions within the tumor microenvironment (TME) significantly influence tumor progression and treatment responses. While single-cell RNA sequencing (scRNA-seq) and spatial genomics facilitate TME exploration, many clinical cohorts are a
Externí odkaz:
https://doaj.org/article/78cfe216b02f40508c2ce44eed5d4500
Autor:
Denis Torre, Nancy J. Francoeur, Yael Kalma, Ilana Gross Carmel, Betsaida S. Melo, Gintaras Deikus, Kimaada Allette, Ron Flohr, Maya Fridrikh, Konstantinos Vlachos, Kent Madrid, Hardik Shah, Ying-Chih Wang, Shwetha H. Sridhar, Melissa L. Smith, Efrat Eliyahu, Foad Azem, Hadar Amir, Yoav Mayshar, Ivan Marazzi, Ernesto Guccione, Eric Schadt, Dalit Ben-Yosef, Robert Sebra
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Human preimplantation development involves extensive remodeling of RNA expression and splicing. However, its transcriptome has been compiled using short-read sequencing data, which fails to capture most full-length mRNAs. Here, we generate a
Externí odkaz:
https://doaj.org/article/c3c20aad7f8e43afbec8ac8c0333cada
Autor:
Ana S. Gonzalez-Reiche, Hala Alshammary, Sarah Schaefer, Gopi Patel, Jose Polanco, Juan Manuel Carreño, Angela A. Amoako, Aria Rooker, Christian Cognigni, Daniel Floda, Adriana van de Guchte, Zain Khalil, Keith Farrugia, Nima Assad, Jian Zhang, Bremy Alburquerque, PARIS/PSP study group, Levy A. Sominsky, Charles Gleason, Komal Srivastava, Robert Sebra, Juan David Ramirez, Radhika Banu, Paras Shrestha, Florian Krammer, Alberto Paniz-Mondolfi, Emilia Mia Sordillo, Viviana Simon, Harm van Bakel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have been reported in immune-compromised individuals and people undergoing immune-modulatory treatments. Although intrahost evolution has been documented, dir
Externí odkaz:
https://doaj.org/article/f68dd420466d4ce3b1c6402bfe4823dc
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
There is interest in measuring the influence of spatial cellular organization on pathophysiology, which is being accomplished through spatial transcriptomics. There the authors present UniCell Deconvolve, a pre-trained deep learning model that predic
Externí odkaz:
https://doaj.org/article/5778b2fc01e34a37bc15916d52529aac
Autor:
Mustafa M. Siddiq, Carlos A. Toro, Nicholas P. Johnson, Jens Hansen, Yuguang Xiong, Wilfredo Mellado, Rosa E. Tolentino, Kaitlin Johnson, Gomathi Jayaraman, Zaara Suhail, Lauren Harlow, Jinye Dai, Kristin G. Beaumont, Robert Sebra, Dianna E. Willis, Christopher P. Cardozo, Ravi Iyengar
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionNeurons transport mRNA and translational machinery to axons for local translation. After spinal cord injury (SCI), de novo translation is assumed to enable neurorepair. Knowledge of the identity of axonal mRNAs that participate in neurore
Externí odkaz:
https://doaj.org/article/e7907528427c4cc4850262c458caa737
Autor:
Huan Wang, Nina Bhardwaj, Naoko Imai, Seunghee Kim-Schulze, Takuro Saito, Jingjing Qi, Sacha Gnjatic, Sumanta K Pal, Matthew D Galsky, Manishkumar Patel, Hui Xie, Robert Sebra, Andrew Uzilov, Jonathan Anker, Rebecca Halperin, Shingo Eikawa, Noah M Hahn
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 8 (2023)
Cisplatin-based chemotherapy has been associated with durable disease control in a small subset of patients with metastatic urothelial cancer. However, the mechanistic basis for this phenomenon has remained elusive. Antitumor immunity may underlie th
Externí odkaz:
https://doaj.org/article/55cbcba3ae0649aeb88c87f1c18bdaa7
Autor:
Susana I. Ramos, Zarmeen M. Mussa, Elisa N. Falk, Balagopal Pai, Bruno Giotti, Kimaada Allette, Peiwen Cai, Fumiko Dekio, Robert Sebra, Kristin G. Beaumont, Alexander M. Tsankov, Nadejda M. Tsankova
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Late prenatal development of the human neocortex encompasses a critical period of gliogenesis and cortical expansion. Here, authors use human transcriptomics to capture transience and diversity of cells in middle and late prenatal development, includ
Externí odkaz:
https://doaj.org/article/f31342a967ee47e0acf711c820e990c0
Autor:
Balagopal Pai, Jessica Tome-Garcia, Wan Sze Cheng, German Nudelman, Kristin G. Beaumont, Saadi Ghatan, Fedor Panov, Elodia Caballero, Kwadwo Sarpong, Lara Marcuse, Jiyeoun Yoo, Yan Jiang, Anne Schaefer, Schahram Akbarian, Robert Sebra, Dalila Pinto, Elena Zaslavsky, Nadejda M. Tsankova
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-19 (2022)
Abstract The pathophysiology of epilepsy underlies a complex network dysfunction between neurons and glia, the molecular cell type-specific contributions of which remain poorly defined in the human disease. In this study, we validated a method that s
Externí odkaz:
https://doaj.org/article/b9a46178f9344e43baf3916ddbf90fec
Autor:
Zeguo Sun, Rui Zhang, Xiao Zhang, Yifei Sun, Pengpeng Liu, Nancy Francoeur, Lei Han, Wan Yee Lam, Zhengzi Yi, Robert Sebra, Martin Walsh, Jinpu Yu, Weijia Zhang
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-24 (2022)
Abstract Background Long Interspersed Nuclear Element-1 (LINE-1, L1) is increasingly regarded as a genetic risk for lung cancer. Transcriptionally active LINE-1 forms a L1-gene chimeric transcript (LCTs), through somatic L1 retrotransposition (LRT) o
Externí odkaz:
https://doaj.org/article/58a9896dcd71451cbe430e99aac31f03