Výsledky vyhledávání - "Robert, Pytlik"

Akademický článek

The Impact of Various Culture Conditions on Human Mesenchymal Stromal Cells Metabolism

Autor: Pavla Tonarova, Katerina Lochovska, Robert Pytlik, Marie Hubalek Kalbacova

Publikováno v: Stem Cells International, Vol 2021 (2021)

In vitro and in vivo analyses are closely connected, and the reciprocal relationship between the two comprises a key assumption with concern to the conducting of meaningful research. The primary purpose of in vitro analysis is to provide a solid back

Externí odkaz: https://doaj.org/article/6e64129381614144a3313d0f0ffb6b8f

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Supplemental figure 2: Protein expression profiles of key regulators of apoptosis in DLBCL cell lines. from Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma

Autor: Pavel Klener, Marek Trneny, Robert Pytlik, Roman Kodet, Mahmudul Alam, Bokang Calvin Lenyeletse Maswabi, Jan Molinsky, Lucie Lateckova, Petra Vockova, Karel Helman, Radek Jaksa, Dana Vejmelkova, Dana Prukova, Jan Soukup, Simona Benesova, Jan Svadlenka, Jan Brazina, Ladislav Andera, Magdalena Klanova

Western blot analysis showing protein expression profile of key regulators of apoptosis in 18 DLBCL cell lines (12 germinal center B-cell-like (GCB) and 6 activated B-cell-like (ABC) DLBCL cell lines). *UPF4D cell line (GCB origin) was derived in our

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c173972cf2e268702b74b82a1e49d1e3
https://doi.org/10.1158/1078-0432.22457130

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Data from Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma

Purpose: To investigate the roles of BCL2, MCL1, and BCL-XL in the survival of diffuse large B-cell lymphoma (DLBCL).Experimental designs: Immunohistochemical analysis of 105 primary DLBCL samples, and Western blot analysis of 18 DLBCL cell lines for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f7657670078fc56e9d1f3aa2eb5276
https://doi.org/10.1158/1078-0432.c.6523509.v1

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Supplemental figure 1: Immunohistochemical (IHC) analysis of BCL2 and MCL1 proteins in formalin-fixed paraffin-embedded tissue samples obtained from patients at dignosis of DLBCL. from Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma

Shown are examples of different levels of semi-quantitative protein expression (0-3).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d072966c6995f80fa38e44a6170501a
https://doi.org/10.1158/1078-0432.22457133

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Supplemental table 1: Semi-quantitative immunohistochemical (IHC) analysis of s.c. DLBCL cell line xenografts. from Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma

To investigate whether the expression level of BCL2 proteins detected by western blot is comparable with the expression level assessed by IHC analysis, we analyzed protein expression (by IHC) of BCL2, MCL1 and BCL-XL from subcutaneous lymphoma xenogr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63969706514c34ab22db984109d7a24f
https://doi.org/10.1158/1078-0432.22457115.v1

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Supplemental figure 6: Acquired resistance of DLBCL cells to HHT is associated with upregulation of BCL-XL protein. from Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma

(A) Comparison of the extent of apopotosis induced by HHT (after 24hrs exposure) in HHT-resistant (HHT-R) clones compared to the original cell lines (CTRL). (B) Western blot analysis demonstrates upregulation of BCL-XL protein in HHT-R clones compare

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883706f3111a5507d671c92a8ec2bf45
https://doi.org/10.1158/1078-0432.22457118

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Supplemental figure 4: Comparison of sensitivity of 18 DLBCL cell lines to HHT, ABT-199 and ABT-737. from Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma

The graphs show the extent of apoptosis of DLBCL cell lines induced by different concentrations of HHT, ABT-199 and ABT-737 after 24hrs exposure to particular agents.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5e50a0a51e72b6007cddc684aa7ff2
https://doi.org/10.1158/1078-0432.22457124.v1

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Supplemental table 2: Comparison of sensitivity of 18 DLBCL cell lines to ABT-199 and HHT. from Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma

Cell of origin (COO), BCL2 expression status and IC100 for ABT-199 (Ã‚ÂµM) and HHT (nM) are shown.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1397d4117a0aff828cfc6dc72b61ae48
https://doi.org/10.1158/1078-0432.22457112.v1

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Akademický článek

Current Immunotherapy Approaches in Non-Hodgkin Lymphomas

Autor: Robert Pytlik, Kamila Polgarova, Jana Karolova, Pavel Klener

Publikováno v: Vaccines, Vol 8, Iss 4, p 708 (2020)

Non-Hodgkin lymphomas (NHLs) are lymphoid malignancies of B- or T-cell origin. Despite great advances in treatment options and significant improvement of survival parameters, a large part of NHL patients either present with a chemotherapy-refractory

Externí odkaz: https://doaj.org/article/5ef409b4224a4d8798d38adf9e4c8e03

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Akademický článek

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