Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Robert, Meller"'
Autor:
Diego Galeano, Imrat, Jeffrey Haltom, Chaylen Andolino, Aliza Yousey, Victoria Zaksas, Saswati Das, Stephen B. Baylin, Douglas C. Wallace, Frank J. Slack, Francisco J. Enguita, Eve Syrkin Wurtele, Dorothy Teegarden, Robert Meller, Daniel Cifuentes, Afshin Beheshti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract MicroRNAs (miRNAs) have been implicated in human disorders, from cancers to infectious diseases. Targeting miRNAs or their target genes with small molecules offers opportunities to modulate dysregulated cellular processes linked to diseases.
Externí odkaz:
https://doaj.org/article/f33890c2c4824222b8db02e8553313a4
Autor:
J. Tyson McDonald, JangKeun Kim, Lily Farmerie, Meghan L. Johnson, Nidia S. Trovao, Shehbeel Arif, Keith Siew, Sergey Tsoy, Yaron Bram, Jiwoon Park, Eliah Overbey, Krista Ryon, Jeffrey Haltom, Urminder Singh, Francisco J. Enguita, Victoria Zaksas, Joseph W. Guarnieri, Michael Topper, Douglas C. Wallace, Cem Meydan, Stephen Baylin, Robert Meller, Masafumi Muratani, D. Marshall Porterfield, Brett Kaufman, Marcelo A. Mori, Stephen B. Walsh, Dominique Sigaudo-Roussel, Saida Mebarek, Massimo Bottini, Christophe A. Marquette, Eve Syrkin Wurtele, Robert E. Schwartz, Diego Galeano, Christopher E. Mason, Peter Grabham, Afshin Beheshti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Our previous research revealed a key microRNA signature that is associated with spaceflight that can be used as a biomarker and to develop countermeasure treatments to mitigate the damage caused by space radiation. Here, we expand on this wo
Externí odkaz:
https://doaj.org/article/0649faa161fd46558b42240dde0a9327
Autor:
Shashwat Deepali Nagar, Priscilla Pemu, Jun Qian, Eric Boerwinkle, Mine Cicek, Cheryl R. Clark, Elizabeth Cohn, Kelly Gebo, Roxana Loperena, Kelsey Mayo, Stephen Mockrin, Lucila Ohno-Machado, Andrea H. Ramirez, Sheri Schully, Ashley Able, Ashley Green, Stephan Zuchner, SEEC Consortium, I. King Jordan, Robert Meller
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The World Health Organization recently defined hypertension and type 2 diabetes (T2D) as modifiable comorbidities leading to dementia and Alzheimer’s disease. In the United States (US), hypertension and T2D are health disparities, with hig
Externí odkaz:
https://doaj.org/article/b71546708faf44d6b850bdc0578b99da
Autor:
Amanda M. Saravia-Butler, Jonathan C. Schisler, Deanne Taylor, Afshin Beheshti, Dan Butler, Cem Meydan, Jonathon Foox, Kyle Hernandez, Chris Mozsary, Christopher E. Mason, Robert Meller
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105310- (2022)
Summary: We analyzed RNA sequencing data from nasal swabs used for SARS-CoV-2 testing. 13% of 317 PCR-negative samples contained over 100 reads aligned to multiple regions of the SARS-CoV-2 genome. Differential gene expression analysis compares the h
Externí odkaz:
https://doaj.org/article/45fb75cf3bd54701930dd145e147532a
Autor:
Beatrice E. Gee, Andrea Pearson, Iris Buchanan-Perry, Roger P. Simon, David R. Archer, Robert Meller
Publikováno v:
Frontiers in Genetics, Vol 12 (2022)
Whole transcriptome RNA-sequencing was performed to quantify RNA expression changes in whole blood samples collected from steady state sickle cell anemia (SCA) and control subjects. Pediatric SCA and control subjects were recruited from Atlanta (GA)
Externí odkaz:
https://doaj.org/article/62428dd295014441a8bae4b21417b177
Autor:
J. Tyson McDonald, Francisco J. Enguita, Deanne Taylor, Robert J. Griffin, Waldemar Priebe, Mark R. Emmett, Mohammad M. Sajadi, Anthony D. Harris, Jean Clement, Joseph M. Dybas, Nukhet Aykin-Burns, Joseph W. Guarnieri, Larry N. Singh, Peter Grabham, Stephen B. Baylin, Aliza Yousey, Andrea N. Pearson, Peter M. Corry, Amanda Saravia-Butler, Thomas R. Aunins, Sadhana Sharma, Prashant Nagpal, Cem Meydan, Jonathan Foox, Christopher Mozsary, Bianca Cerqueira, Viktorija Zaksas, Urminder Singh, Eve Syrkin Wurtele, Sylvain V. Costes, Gustavo Gastão Davanzo, Diego Galeano, Alberto Paccanaro, Suzanne L. Meinig, Robert S. Hagan, Natalie M. Bowman, Matthew C. Wolfgang, Selin Altinok, Nicolae Sapoval, Todd J. Treangen, Pedro M. Moraes-Vieira, Charles Vanderburg, Douglas C. Wallace, Jonathan C. Schisler, Christopher E. Mason, Anushree Chatterjee, Robert Meller, Afshin Beheshti, Shannon M. Wallet, Robert Maile, Jason R. Mock, Jose L. Torres-Castillo, Miriya K. Love, Will Lovell, Colleen Rice, Olivia Mitchem, Dominique Burgess, Jessica Suggs, Jordan Jacobs
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109839- (2021)
Summary: MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation that have a major impact on many diseases and provide an exciting avenue toward antiviral therapeutics. From patient transcriptomic data, we determ
Externí odkaz:
https://doaj.org/article/86972322eb3c4fa78fa77d4ae3931268
Autor:
Mian Xie, Tiandong Leng, Samaneh Maysami, Andrea Pearson, Roger Simon, Zhi-Gang Xiong, Robert Meller
Publikováno v:
Biomolecules, Vol 12, Iss 9, p 1214 (2022)
In this study, we characterize biophysical changes in NMDA receptor function in response to brief non-injurious ischemic stress (ischemic preconditioning). Electrophysiological studies show NMDA receptor function is reduced following preconditioning
Externí odkaz:
https://doaj.org/article/3cb47d0b3c104b92ac2e1cbc15fc6112
Autor:
Eliah G. Overbey, Amanda M. Saravia-Butler, Zhe Zhang, Komal S. Rathi, Homer Fogle, Willian A. da Silveira, Richard J. Barker, Joseph J. Bass, Afshin Beheshti, Daniel C. Berrios, Elizabeth A. Blaber, Egle Cekanaviciute, Helio A. Costa, Laurence B. Davin, Kathleen M. Fisch, Samrawit G. Gebre, Matthew Geniza, Rachel Gilbert, Simon Gilroy, Gary Hardiman, Raúl Herranz, Yared H. Kidane, Colin P.S. Kruse, Michael D. Lee, Ted Liefeld, Norman G. Lewis, J. Tyson McDonald, Robert Meller, Tejaswini Mishra, Imara Y. Perera, Shayoni Ray, Sigrid S. Reinsch, Sara Brin Rosenthal, Michael Strong, Nathaniel J. Szewczyk, Candice G.T. Tahimic, Deanne M. Taylor, Joshua P. Vandenbrink, Alicia Villacampa, Silvio Weging, Chris Wolverton, Sarah E. Wyatt, Luis Zea, Sylvain V. Costes, Jonathan M. Galazka
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102361- (2021)
Summary: With the development of transcriptomic technologies, we are able to quantify precise changes in gene expression profiles from astronauts and other organisms exposed to spaceflight. Members of NASA GeneLab and GeneLab-associated analysis work
Externí odkaz:
https://doaj.org/article/db05f4c13f9d4050b634492f121e3d68
Autor:
Amber M. Paul, Margareth Cheng-Campbell, Elizabeth A. Blaber, Sulekha Anand, Sharmila Bhattacharya, Sara R. Zwart, Brian E. Crucian, Scott M. Smith, Robert Meller, Peter Grabham, Afshin Beheshti
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101747- (2020)
Summary: Spaceflight missions can cause immune system dysfunction in astronauts with little understanding of immune outcomes in deep space. This study assessed immune responses in mice following ground-based, simulated deep spaceflight conditions, co
Externí odkaz:
https://doaj.org/article/dd95f6efd99344169798c95585dd9c53
Autor:
Francisco J. Enguita, Ana Lúcia Leitão, J. Tyson McDonald, Viktorija Zaksas, Saswati Das, Diego Galeano, Deanne Taylor, Eve Syrkin Wurtele, Amanda Saravia-Butler, Stephen B. Baylin, Robert Meller, D. Marshall Porterfield, Douglas C. Wallace, Jonathan C. Schisler, Christopher E. Mason, Afshin Beheshti
Publikováno v:
Theranostics. 12:3946-3962
SUMMARYViral infections are complex processes based on an intricate network of molecular interactions. The infectious agent hijacks components of the cellular machinery for its profit, circumventing the natural defense mechanisms triggered by the inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f610f162ed48e661ef5a3189ca0a53
https://doi.org/10.7150/thno.73268
https://doi.org/10.7150/thno.73268