Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Robert, McEwen"'
Autor:
Lillian M. Smyth, Gerald Batist, Funda Meric-Bernstam, Peter Kabos, Iben Spanggaard, Ana Lluch, Komal Jhaveri, Andrea Varga, Andrea Wong, Alison M. Schram, Helen Ambrose, T. Hedley Carr, Elza C. de Bruin, Carolina Salinas-Souza, Andrew Foxley, Joana Hauser, Justin P. O. Lindemann, Rhiannon Maudsley, Robert McEwen, Michele Moschetta, Myria Nikolaou, Gaia Schiavon, Pedram Razavi, Udai Banerji, José Baselga, David M. Hyman, Sarat Chandarlapaty
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-7 (2021)
Abstract Five to ten percent of ER+ metastatic breast cancer (MBC) tumors harbor somatic PTEN mutations. Loss of function of this tumor-suppressor gene defines a highly aggressive, treatment-refractory disease for which new therapies are urgently nee
Externí odkaz:
https://doaj.org/article/97cb292e26054c75a968bad21fc37c9b
Autor:
Marla Lipsyc-Sharf, Elza C. de Bruin, Katheryn Santos, Robert McEwen, Daniel Stetson, Ashka Patel, Gregory J. Kirkner, Melissa E. Hughes, Sara M. Tolaney, Ann H. Partridge, Ian E. Krop, Charlene Knape, Ute Feger, Giovanni Marsico, Karen Howarth, Eric P. Winer, Nancy U. Lin, Heather A. Parsons
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 40(22)
PURPOSE To examine the prevalence and dynamics of circulating tumor DNA (ctDNA) and its association with metastatic recurrence in patients with high-risk early-stage hormone receptor–positive breast cancer (HR+ BC) more than 5 years from diagnosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::508f57999cac092877c246d9fe1895f3
https://pubmed.ncbi.nlm.nih.gov/35658519
https://pubmed.ncbi.nlm.nih.gov/35658519
Autor:
Norah J Shire, Alyssa B Klein, Asieh Golozar, Jenna M Collins, Kathy H Fraeman, Beth L Nordstrom, Robert McEwen, Todd Hembrough, Naiyer A Rizvi
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238358 (2020)
BackgroundMutations in STK11 (STK11m) and frequently co-occurring KRAS mutations (KRASm/STK11m) are associated with poor survival in metastatic NSCLC (mNSCLC) immuno-oncology trials. There are limited data regarding the prognostic significance of the
Externí odkaz:
https://doaj.org/article/a5de3eaa4070440fa054983d2d067b68
Autor:
Sabina C. Cosulich, Stephen Green, Oona Delpuech, Robert McEwen, Urszula M. Polanska, Christine M. Chresta, Martin Pass, Kurt G. Pike, Teresa Klinowska, Graham Bigley, Barry R. Davies, Zoe Howard, Michael Grondine, James W.T. Yates, Celina M. D'Cruz, Teeru Bihani, Jon Curwen, Sylvie M. Guichard
Supplementary data on cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b4e1c79aa3f231a187d9a02f72da17
https://doi.org/10.1158/1535-7163.22505964
https://doi.org/10.1158/1535-7163.22505964
Autor:
Sabina C. Cosulich, Stephen Green, Oona Delpuech, Robert McEwen, Urszula M. Polanska, Christine M. Chresta, Martin Pass, Kurt G. Pike, Teresa Klinowska, Graham Bigley, Barry R. Davies, Zoe Howard, Michael Grondine, James W.T. Yates, Celina M. D'Cruz, Teeru Bihani, Jon Curwen, Sylvie M. Guichard
Pharmacokinetics and PK/PD relationships for AZD2014
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98473f6fc21ae8f367d8c0594f8ae037
https://doi.org/10.1158/1535-7163.22505979
https://doi.org/10.1158/1535-7163.22505979
Autor:
Stephen Green, Francisco Cruzalegui, Lara Ward, Sabina C. Cosulich, Marie Cumberbatch, Alys Jones, Rebecca Ellston, Lyndsey Hanson, Phillippa Dudley, Oona Delpuech, Alvaro Avivar-Valderas, Pablo Morentin Gutierrez, Myria Nikolaou, Urszula M. Polanska, Robert McEwen, Cath Trigwell, Urs J. Hancox, Kevin Hudson
The PIK3CA gene, encoding the p110α catalytic unit of PI3Kα, is one of the most frequently mutated oncogenes in human cancer. Hence, PI3Kα is a target subject to intensive efforts in identifying inhibitors and evaluating their therapeutic potentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282c99e85c18ba37f3ab7df829957e4b
https://doi.org/10.1158/1535-7163.c.6538756
https://doi.org/10.1158/1535-7163.c.6538756
Autor:
Stephen Green, Francisco Cruzalegui, Lara Ward, Sabina C. Cosulich, Marie Cumberbatch, Alys Jones, Rebecca Ellston, Lyndsey Hanson, Phillippa Dudley, Oona Delpuech, Alvaro Avivar-Valderas, Pablo Morentin Gutierrez, Myria Nikolaou, Urszula M. Polanska, Robert McEwen, Cath Trigwell, Urs J. Hancox, Kevin Hudson
Timecourse of PI3K pathway inhibition in MCF7 cells illustrating pathway reactivation over time.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00456e2abd72de83084efc8b4c7deb65
https://doi.org/10.1158/1535-7163.22507708
https://doi.org/10.1158/1535-7163.22507708
Autor:
Sabina C. Cosulich, Jason S. Carroll, Robert McEwen, Igor Chernukhin, Mandy Lawson, Azadeh Cheraghchi-Bashi, Urszula M. Polanska, Anna D. Staniszewska, Larissa S. Carnevalli, Jon O. Curwen, Oona Delpuech, Rasmus Siersbaek, Claire Crafter, Chrysiis Michaloglou
Supplementary Figure S1. Vistusertib (AZD2014) causes a decrease in RB phosphorylation in the absence of cell cycle arrest. Supplementary Figure S2. Different mTOR inhibitors in combination with palbociclib cause a decrease in cell viability. Supplem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2971446864fbedb32439af08aab612
https://doi.org/10.1158/1535-7163.22510243
https://doi.org/10.1158/1535-7163.22510243
Autor:
Stephen Green, Francisco Cruzalegui, Lara Ward, Sabina C. Cosulich, Marie Cumberbatch, Alys Jones, Rebecca Ellston, Lyndsey Hanson, Phillippa Dudley, Oona Delpuech, Alvaro Avivar-Valderas, Pablo Morentin Gutierrez, Myria Nikolaou, Urszula M. Polanska, Robert McEwen, Cath Trigwell, Urs J. Hancox, Kevin Hudson
Tumor cell line panel composition and growth inhibition sensitivity (GI50) to AZD8835.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4782fd316b02ec8951d691e4f7122f
https://doi.org/10.1158/1535-7163.22507675.v1
https://doi.org/10.1158/1535-7163.22507675.v1
Autor:
Sabina C. Cosulich, Jason S. Carroll, Robert McEwen, Igor Chernukhin, Mandy Lawson, Azadeh Cheraghchi-Bashi, Urszula M. Polanska, Anna D. Staniszewska, Larissa S. Carnevalli, Jon O. Curwen, Oona Delpuech, Rasmus Siersbaek, Claire Crafter, Chrysiis Michaloglou
The cyclin dependent kinase (CDK)–retinoblastoma (RB)–E2F pathway plays a critical role in the control of cell cycle in estrogen receptor–positive (ER+) breast cancer. Small-molecule inhibitors of CDK4/6 have shown promise in this tumor type in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a430fac5fb19944258d4dc125065e6b
https://doi.org/10.1158/1535-7163.c.6539551.v1
https://doi.org/10.1158/1535-7163.c.6539551.v1