Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Robert, Ledeen"'
Publikováno v:
FEBS Open Bio, Vol 13, Iss 9, Pp 1651-1657 (2023)
This study attempts to answer the question of whether mice with biallelic and monoallelic disruption of the St3gal5 (GM3 synthase) gene might benefit from GM1 replacement therapy. The GM3 produced by this sialyltransferase gives rise to downstream GD
Externí odkaz:
https://doaj.org/article/01e38b64fcdb4d55a0368214a02f3bce
Publikováno v:
Biomedicines, Vol 11, Iss 1, p 209 (2023)
The purpose of this study was to determine whether the age-related decline in a-series gangliosides (especially GM1), shown to be a factor in the brain-related etiology of Parkinson’s disease (PD), also pertains to the peripheral nervous system (PN
Externí odkaz:
https://doaj.org/article/1d05e760741742b1a765e26a3c6640f7
Autor:
Suman Chowdhury, Robert Ledeen
Publikováno v:
Biomolecules, Vol 12, Iss 2, p 173 (2022)
We have endeavored in this review to summarize our findings, which point to a systemic deficiency of ganglioside GM1 in Parkinson’s disease (PD) tissues. These include neuronal tissues well known to be involved in PD, such as substantia nigra of th
Externí odkaz:
https://doaj.org/article/26659577cf6244e581f8bc208b5e14f5
Publikováno v:
Glycoconjugate Journal. 39:75-82
Following our initial reports on subnormal levels of GM1 in the substantia nigra and occipital cortex of Parkinson’s disease (PD) patients, we have examined additional tissues from such patients and found these are also deficient in the ganglioside
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da9ca29d723a1aa4042924af22a10258
https://doi.org/10.1007/s10719-021-10025-9
https://doi.org/10.1007/s10719-021-10025-9
Autor:
Robert Ledeen, Suman Chowdhury
Publikováno v:
Advances in Neurobiology ISBN: 9783031123894
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba680beb6ddc5b9bbd4b80026fbe6aef
https://doi.org/10.1007/978-3-031-12390-0_13
https://doi.org/10.1007/978-3-031-12390-0_13
Autor:
Robert, Ledeen, Suman, Chowdhury
Publikováno v:
Advances in neurobiology. 29
The main purpose of this chapter is to summarize the chief findings on ganglioside changes/interactions with some of the neurodegenerative disorders. For the latter we have focused on three diseases that have seen especially intensive study in that r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4dc1ececfbabb1d0267be9451320604f
https://pubmed.ncbi.nlm.nih.gov/36255682
https://pubmed.ncbi.nlm.nih.gov/36255682
Autor:
Suman Chowdhury, Robert Ledeen
Publikováno v:
Biomolecules. 12(2)
We have endeavored in this review to summarize our findings, which point to a systemic deficiency of ganglioside GM1 in Parkinson’s disease (PD) tissues. These include neuronal tissues well known to be involved in PD, such as substantia nigra of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d781aba3a0e18ece040e42fdc0f23f5
https://pubmed.ncbi.nlm.nih.gov/35204675
https://pubmed.ncbi.nlm.nih.gov/35204675
Autor:
Robert, Ledeen, Gusheng, Wu
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1804
This review begins by attempting to recount some of the pioneering discoveries that first identified the presence of gangliosides in the nervous system, their structures and topography. This is presented as prelude to the current emphasis on physiolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cefa448e4bdab611f177cddbd377ddc3
https://pubmed.ncbi.nlm.nih.gov/29926403
https://pubmed.ncbi.nlm.nih.gov/29926403
This volume contains the Proceedings of the Meeting'Neuronal plasticity and gangliosides'which was held at Mantova, Italy, on May 29-31, 1985, as a satellite to the Tenth Meeting of the International Society for Neurochemistry, (Riva del Garda, Italy
Publikováno v:
Journal of Lipid Research, Vol 9, Iss 1, Pp 129-136 (1968)
Gangliosides from brain of an 8 yr old boy with subacute sclerosing leukoencephalitis have been studied in terms of pattern and structure. Thin-layer chromatography showed that both gray and white matter have a highly abnormal pattern, with elevation
Externí odkaz:
https://doaj.org/article/b580e3bf0e334f789e4227cdb029e20a