Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Robert, Layfield"'
Autor:
Katherine E. White, Hannah L. Bailey, Barry S. Shaw, Philippine C. Geiszler, Raquel Mesquita-Ribeiro, Daniel Scott, Robert Layfield, Sébastien Serres
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Extracellular vesicles (EVs) are secreted by all cells in the CNS, including neurons and astrocytes. EVs are lipid membrane enclosed particles loaded with various bioactive cargoes reflecting the dynamic activities of cells of origin. In contrast to
Externí odkaz:
https://doaj.org/article/c3d8d0db27c640d6b61f09654f9f5c91
Autor:
Judyta Olszewski, Rachael A. Hall, Lisette M. Kootker, Neil J. Oldham, Robert Layfield, Barry Shaw, Leon Derksen, Martijn Manders, Tim Hart, Sarah A. Schrader
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Skeletal remains discovered in Simon’s Town, South Africa, were hypothesised as being associated with a former Dutch East India Company (VOC) hospital. We report a novel combined osteological and biochemical approach to these poorly-preser
Externí odkaz:
https://doaj.org/article/e4b927aed09e4a04a0a659ad303513b9
Autor:
Ben Milborne, Lauren Murrell, Ian Cardillo-Zallo, Jeremy Titman, Louise Briggs, Colin Scotchford, Alexander Thompson, Robert Layfield, Ifty Ahmed
Publikováno v:
Bioengineering, Vol 9, Iss 11, p 611 (2022)
Phosphate-based glasses (PBGs) are promising materials for bone repair and regeneration as they can be formulated to be compositionally similar to the inorganic components of bone. Alterations to the PBG formulation can be used to tailor their degrad
Externí odkaz:
https://doaj.org/article/e20cfbfe730e4507a23bb48c88364261
Autor:
Farhana Haque, Pascale Varlet, Julien Puntonet, Lisa Storer, Aikaterini Bountali, Ruman Rahman, Jacques Grill, Angel M Carcaboso, Chris Jones, Robert Layfield, Richard G Grundy
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-9 (2017)
Abstract Missense somatic mutations affecting histone H3.1 and H3.3 proteins are now accepted as the hallmark of paediatric diffuse intrinsic pontine gliomas (DIPG), non-brain stem paediatric high grade gliomas (pHGG) as well as a subset of adult gli
Externí odkaz:
https://doaj.org/article/d79d778216bc4bf9a322c49b00339e6f
Autor:
Robert Layfield, Elena Faccenda
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Ubiquitination (a.k.a. ubiquitylation) is a protein post-translational modification that typically requires the sequential action of three enzymes: E1 (ubiquitin-activating enzymes), E2 (ubiquitin-conjugating enzymes), and E3 (ubiquitin ligases) [30]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbe9141059b65ee6bd0eb3a633e71aa0
https://doi.org/10.2218/gtopdb/f1023/2023.1
https://doi.org/10.2218/gtopdb/f1023/2023.1
Autor:
Lucio Manzi, Andrew S. Barrow, Daniel Scott, Robert Layfield, Timothy G. Wright, John E. Moses, Neil J. Oldham
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Mapping protein-ligand interactions is fundamental to advance the understanding of cellular processes and to develop drug discovery strategies. Here, the authors present a photo-activated probe that allows highly efficient labelling and identificatio
Externí odkaz:
https://doaj.org/article/e5438de36b074b1c86bc4b655e92a87c
Autor:
Rhys C. Griffiths, Frances R. Smith, Diyuan Li, Jasmine Wyatt, David M. Rogers, Jed E. Long, Lola M. L. Cusin, Patrick J. Tighe, Robert Layfield, Jonathan D. Hirst, Manuel M. Müller, Nicholas J. Mitchell
Publikováno v:
Chemistry – A European Journal. 29
The site-selective modification of peptides and proteins facilitates the preparation of targeted therapeutic agents and tools to interrogate fundamental biochemistry. Among the numerous bioconjugation techniques developed to install groups of interes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80caa832813ad59d1a50ddd17c603d4f
https://doi.org/10.1002/chem.202202503
https://doi.org/10.1002/chem.202202503
Autor:
Robert Layfield, Elena Faccenda
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2022
Ubiquitination (a.k.a. ubiquitylation) is a protein post-translational modification that typically requires the sequential action of three enzymes: E1 (ubiquitin-activating enzymes), E2 (ubiquitin-conjugating enzymes), and E3 (ubiquitin ligases) [28]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05ec280e8ca3e59a47e62e60443c6584
https://doi.org/10.2218/gtopdb/f1023/2022.3
https://doi.org/10.2218/gtopdb/f1023/2022.3
Publikováno v:
Protein expression and purification. 203
Post-translational modifications (PTMs) are important for protein folding and activity, and the ability to recreate physiologically relevant PTM profiles on recombinantly-expressed proteins is vital for meaningful functional analysis. The ETS transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6b5cf6d9e4e69df1709e95f5d6f5a6
https://pubmed.ncbi.nlm.nih.gov/36528218
https://pubmed.ncbi.nlm.nih.gov/36528218
Autor:
Rhys C. Griffiths, Huw E. L. Williams, Nick Mitchell, Jed Long, Frances R. Smith, Robert Layfield
Publikováno v:
Angewandte Chemie (International Ed. in English)
The development of site‐selective chemistry targeting the canonical amino acids enables the controlled installation of desired functionalities into native peptides and proteins. Such techniques facilitate the development of polypeptide conjugates t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c82209a4896142145546a7e41a28e2f6
https://doi.org/10.1002/ange.202006260
https://doi.org/10.1002/ange.202006260