Zobrazeno 1 - 10
of 307
pro vyhledávání: '"Robert, Lafyatis"'
Autor:
Ludivine Renaud, Carole L. Wilson, Robert Lafyatis, Lynn M. Schnapp, Carol A. Feghali-Bostwick
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110010- (2024)
Summary: Systemic sclerosis (SSc) is a chronic disease characterized by fibrosis and vascular abnormalities in the skin and internal organs, including the lung. SSc-associated pulmonary fibrosis (SSc-PF) is the leading cause of death in SSc patients.
Externí odkaz:
https://doaj.org/article/3edca46345f34936801569b0ae6d94ae
Autor:
Feiyang Ma, Pei-Suen Tsou, Mehrnaz Gharaee-Kermani, Olesya Plazyo, Xianying Xing, Joseph Kirma, Rachael Wasikowski, Grace A. Hile, Paul W. Harms, Yanyun Jiang, Enze Xing, Mio Nakamura, Danielle Ochocki, William D. Brodie, Shiv Pillai, Emanual Maverakis, Matteo Pellegrini, Robert L. Modlin, John Varga, Lam C. Tsoi, Robert Lafyatis, J. Michelle Kahlenberg, Allison C. Billi, Dinesh Khanna, Johann E. Gudjonsson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Systemic sclerosis (SSc) is a devastating autoimmune disease characterized by excessive production and accumulation of extracellular matrix, leading to fibrosis of skin and other internal organs. However, the main cellular participants in SS
Externí odkaz:
https://doaj.org/article/3b5a5e9a32fc4187b638ed4405b8d22c
Autor:
Tetsuo Toyama, Tatiana V. Kudryashova, Asako Ichihara, Stefania Lenna, Agnieszka Looney, Yuanjun Shen, Lifeng Jiang, Leyla Teos, Theodore Avolio, Derek Lin, Ulas Kaplan, Grace Marden, Vrinda Dambal, Dmitry Goncharov, Horace Delisser, Robert Lafyatis, Francesca Seta, Elena A. Goncharova, Maria Trojanowska
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-20 (2023)
Abstract Pulmonary arterial hypertension (PAH) is a life-threatening condition characterized by a progressive increase in pulmonary vascular resistance leading to right ventricular failure and often death. Here we report that deficiency of transcript
Externí odkaz:
https://doaj.org/article/eaede2ae9a2148b3a1f591eaf455e313
Autor:
Minxue Jia, Lorena Rosas, Maria G. Kapetanaki, Tracy Tabib, John Sebrat, Tamara Cruz, Anna Bondonese, Ana L. Mora, Robert Lafyatis, Mauricio Rojas, Panayiotis V. Benos
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-13 (2023)
Abstract Background Idiopathic Pulmonary Fibrosis (IPF) is an age-associated progressive lung disease with accumulation of scar tissue impairing gas exchange. Previous high-throughput studies elucidated the role of cellular heterogeneity and molecula
Externí odkaz:
https://doaj.org/article/dde4cdd40c214eafbea635dd5cd10002
Autor:
Alyxzandria M. Gaydosik, Connor J. Stonesifer, Tracy Tabib, Robert Lafyatis, Larisa J. Geskin, Patrizia Fuschiotti
Publikováno v:
JCI Insight, Vol 8, Iss 19 (2023)
Malignant T lymphocyte proliferation in mycosis fungoides (MF) is largely restricted to the skin, implying that malignant cells are dependent on their specific cutaneous tumor microenvironment (TME), including interactions with non-malignant immune a
Externí odkaz:
https://doaj.org/article/0ebab179c9f341708c1df1b7e322329c
Autor:
Cornelius H. L. Kürten, Aditi Kulkarni, Anthony R. Cillo, Patricia M. Santos, Anna K. Roble, Sayali Onkar, Carly Reeder, Stephan Lang, Xueer Chen, Umamaheswar Duvvuri, Seungwon Kim, Angen Liu, Tracy Tabib, Robert Lafyatis, Jian Feng, Shou-Jiang Gao, Tullia C. Bruno, Dario A. A. Vignali, Xinghua Lu, Riyue Bao, Lazar Vujanovic, Robert L. Ferris
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The tumor microenvironment (TME) has an important role in Head and Neck Squamous Cell Carcinoma (HNSCC) progression. Here, using single-cell RNA sequencing and multiplexed imaging, the authors report the cellular complexity of the TME in patients wit
Externí odkaz:
https://doaj.org/article/2771653d57ef4d11b987a7dbc52724d2
Autor:
Xueer Chen, Lujia Chen, Cornelius H L Kürten, Fattaneh Jabbari, Lazar Vujanovic, Ying Ding, Binfeng Lu, Kevin Lu, Aditi Kulkarni, Tracy Tabib, Robert Lafyatis, Gregory F Cooper, Robert Ferris, Xinghua Lu
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 12, p e1010761 (2022)
Cells within a tumor microenvironment (TME) dynamically communicate and influence each other's cellular states through an intercellular communication network (ICN). In cancers, intercellular communications underlie immune evasion mechanisms of indivi
Externí odkaz:
https://doaj.org/article/c01ab86f3e544c7598abc762487d6f9a
Autor:
Dinesh Khanna, Cristina Padilla, Lam C. Tsoi, Vivek Nagaraja, Puja P. Khanna, Tracy Tabib, J. Michelle Kahlenberg, Amber Young, Suiyuan Huang, Johann E. Gudjonsson, David A. Fox, Robert Lafyatis
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
BACKGROUND Systemic sclerosis (SSc) is an autoimmune, connective tissue disease characterized by vasculopathy and fibrosis of the skin and internal organs.METHODS We randomized 15 participants with early diffuse cutaneous SSc to tofacitinib 5 mg twic
Externí odkaz:
https://doaj.org/article/c75c7f302c8941289e403e34846ce699
Autor:
Tracy Tabib, Mengqi Huang, Nina Morse, Anna Papazoglou, Rithika Behera, Minxue Jia, Melissa Bulik, Daisy E. Monier, Panayiotis V. Benos, Wei Chen, Robyn Domsic, Robert Lafyatis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Myofibroblasts drive fibrosis in systemic sclerosis (SSc), but the cellular progenitors are unknown. Utilizing single cell RNA-sequencing, the authors show that SSc dermal myofibroblasts arise in a two-step process from SFRP2/DPP4-expressing progenit
Externí odkaz:
https://doaj.org/article/315941fe1fd14c9aa1d7eb8778f6f9fe
Autor:
Ayana T. Ruffin, Anthony R. Cillo, Tracy Tabib, Angen Liu, Sayali Onkar, Sheryl R. Kunning, Caleb Lampenfeld, Huda I. Atiya, Irina Abecassis, Cornelius H. L. Kürten, Zengbiao Qi, Ryan Soose, Umamaheswar Duvvuri, Seungwon Kim, Steffi Oesterrich, Robert Lafyatis, Lan G. Coffman, Robert L. Ferris, Dario A. A. Vignali, Tullia C. Bruno
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Recent studies have highlighted the importance of B cells and tertiary lymphoid structures (TLS) in the modulation of anti-tumor immune responses. Here, the authors characterize how HPV status influences the phenotype of tumor infiltrating B cells in
Externí odkaz:
https://doaj.org/article/e83ecb50387b47eaba497a672e531424