Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Robert, Hudkins"'
Autor:
Babu G, Sundar, Thomas, Bailey, Edward, Bacon, Lisa, Aimone, Zeqi, Huang, Jacquelyn, Lyons, Rita, Raddatz, Robert, Hudkins
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(18)
Pyridazinone 1 was recently reported as a potent H(3)R antagonist with good drug-like properties and in vivo activity. A series of constrained amine analogs of 1 was synthesized to identify compounds with improved pharmacokinetic profiles. From these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a8196628b9170a7a7ccee21d28ca165b
https://pubmed.ncbi.nlm.nih.gov/21824776
https://pubmed.ncbi.nlm.nih.gov/21824776
Autor:
Sheila J, Miknyoczki, Susan, Jones-Bolin, Sonya, Pritchard, Kathryn, Hunter, Hugh, Zhao, Weihua, Wan, Mark, Ator, Ronald, Bihovsky, Robert, Hudkins, Sankar, Chatterjee, Andres, Klein-Szanto, Craig, Dionne, Bruce, Ruggeri
Publikováno v:
Molecular cancer therapeutics. 2(4)
Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear zinc finger DNA-binding protein that is implicated in the repair of DNA damage. Inhibition of PARP-1 through genetic knockouts causes cells to become hypersensitive to various chemotherapeutic agent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0c3111966e99bf519262003cebd150d4
https://pubmed.ncbi.nlm.nih.gov/12700281
https://pubmed.ncbi.nlm.nih.gov/12700281