Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Robert, Hollingworth"'
Autor:
Laura J. Grange, John J. Reynolds, Farid Ullah, Bertrand Isidor, Robert F. Shearer, Xenia Latypova, Ryan M. Baxley, Antony W. Oliver, Anil Ganesh, Sophie L. Cooke, Satpal S. Jhujh, Gavin S. McNee, Robert Hollingworth, Martin R. Higgs, Toyoaki Natsume, Tahir Khan, Gabriel Á. Martos-Moreno, Sharon Chupp, Christopher G. Mathew, David Parry, Michael A. Simpson, Nahid Nahavandi, Zafer Yüksel, Mojgan Drasdo, Anja Kron, Petra Vogt, Annemarie Jonasson, Saad Ahmed Seth, Claudia Gonzaga-Jauregui, Karlla W. Brigatti, Alexander P. A. Stegmann, Masato Kanemaki, Dragana Josifova, Yuri Uchiyama, Yukiko Oh, Akira Morimoto, Hitoshi Osaka, Zineb Ammous, Jesús Argente, Naomichi Matsumoto, Constance T.R.M. Stumpel, Alexander M. R. Taylor, Andrew P. Jackson, Anja-Katrin Bielinsky, Niels Mailand, Cedric Le Caignec, Erica E. Davis, Grant S. Stewart
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
The SMC5/6 complex is critical for genome stability. Here, the authors identify mutations in SLF2 and SMC5 as cause of Atelís Syndrome characterized by microcephaly, short stature, anemia, segmented chromosomes and mosaic variegated hyperploidy.
Externí odkaz:
https://doaj.org/article/bfe3845b80824c5996d10d21e1575e9d
Autor:
Bassam Abu-Libdeh, Satpal S. Jhujh, Srijita Dhar, Joshua A. Sommers, Arindam Datta, Gabriel M.C. Longo, Laura J. Grange, John J. Reynolds, Sophie L. Cooke, Gavin S. McNee, Robert Hollingworth, Beth L. Woodward, Anil N. Ganesh, Stephen J. Smerdon, Claudia M. Nicolae, Karina Durlacher-Betzer, Vered Molho-Pessach, Abdulsalam Abu-Libdeh, Vardiella Meiner, George-Lucian Moldovan, Vassilis Roukos, Tamar Harel, Robert M. Brosh Jr., Grant S. Stewart
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 5 (2022)
Despite being the first homolog of the bacterial RecQ helicase to be identified in humans, the function of RECQL1 remains poorly characterized. Furthermore, unlike other members of the human RECQ family of helicases, mutations in RECQL1 have not been
Externí odkaz:
https://doaj.org/article/e82e799461ca42b1a71605c628f57492
Autor:
Tareq Abualfaraj, Nafiseh Chalabi Hagkarim, Robert Hollingworth, Laura Grange, Satpal Jhujh, Grant S. Stewart, Roger J. Grand
Publikováno v:
Viruses, Vol 13, Iss 12, p 2444 (2021)
The adenovirus 12 early region 1B55K (Ad12E1B55K) protein has long been known to cause non-random damage to chromosomes 1 and 17 in human cells. These sites, referred to as Ad12 modification sites, have marked similarities to classic fragile sites. I
Externí odkaz:
https://doaj.org/article/b5e37f1dd3b2439ab39b2c81ab6bf2a7
Autor:
Robert Hollingworth, George L. Skalka, Grant S. Stewart, Andrew D. Hislop, David J. Blackbourn, Roger J. Grand
Publikováno v:
Viruses, Vol 7, Iss 6, Pp 2908-2927 (2015)
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causative agent of several human malignancies. Human tumour viruses such as KSHV are known to interact with the DNA damage response (DDR), the molecular pathways that recognise and repair lesion
Externí odkaz:
https://doaj.org/article/bf274c40a8294e0e8cddb1ad49cc0055
Autor:
Robert Hollingworth, Roger J Grand
Publikováno v:
Viruses, Vol 7, Iss 5, Pp 2542-2591 (2015)
With between 10% and 15% of human cancers attributable to viral infection, there is great interest, from both a scientific and clinical viewpoint, as to how these pathogens modulate host cell functions. Seven human tumour viruses have been identified
Externí odkaz:
https://doaj.org/article/31292e1463714cc0ba9bfb5e1179621d
Autor:
Robert Hollingworth, Roger J. Grand
Publikováno v:
Viruses, Vol 7, Iss 6, Pp 3201-3203 (2015)
We have noted a number of errors in the references of this manuscript.[...]
Externí odkaz:
https://doaj.org/article/924557b06cd743e096a3b384575bc999
Publikováno v:
The Journal of General Virology
Gammaherpesviruses establish lifelong latent infection in B lymphocytes and are the causative agent of several B-cell malignancies and lymphoproliferative disorders. While a quiescent latent infection allows these pathogens to evade immune detection,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40d1e05c93e06e499ece2d06eea985e
https://doi.org/10.1099/jgv.0.001444
https://doi.org/10.1099/jgv.0.001444
Autor:
Bassam Abu-Libdeh, Satpal S. Jhujh, Srijita Dhar, Joshua A. Sommers, Arindam Datta, Gabriel M.C. Longo, Laura J. Grange, John J. Reynolds, Sophie L. Cooke, Gavin S. McNee, Robert Hollingworth, Beth L. Woodward, Anil N. Ganesh, Stephen J. Smerdon, Claudia M. Nicolae, Karina Durlacher-Betzer, Vered Molho-Pessach, Abdulsalam Abu-Libdeh, Vardiella Meiner, George-Lucian Moldovan, Vassilis Roukos, Tamar Harel, Robert M. Brosh, Grant S. Stewart
Publikováno v:
The Journal of clinical investigation. 132(5)
Despite being the first homolog of the bacterial RecQ helicase to be identified in humans, the function of RECQL1 remains poorly characterized. Furthermore, unlike other members of the human RECQ family of helicases, mutations in RECQL1 have not been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ea6e07bdb7a8cafd90205c4190fa79
https://pubmed.ncbi.nlm.nih.gov/35025765
https://pubmed.ncbi.nlm.nih.gov/35025765
Publikováno v:
Biomolecules, Vol 6, Iss 1, p 2 (2016)
RNA viruses are a genetically diverse group of pathogens that are responsible for some of the most prevalent and lethal human diseases. Numerous viruses introduce DNA damage and genetic instability in host cells during their lifecycles and some speci
Externí odkaz:
https://doaj.org/article/a69b150efbaa4254837101e6efc8fc55
Autor:
Robert Hollingworth, Matthew Bedford, Andrew D Beggs, Tariq Iqbal, Richard D. Horniblow, Chris Tselepis, Neeraj Lal, Emily Sutton, Sarah Evans
Publikováno v:
Cancer Science
A role for iron in carcinogenesis is supported by evidence that iron metabolism proteins are modulated in cancer progression. To date, however, the expression of iron regulatory protein‐2 (IRP2), which is known to regulate several iron metabolism p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e87bf987ffff5ec1c2dba38f8731ef
https://doi.org/10.1111/cas.13234
https://doi.org/10.1111/cas.13234