Non-viral expression of chimeric antigen receptors with multiplex gene editing in primary T cells

Autor: Dan Cappabianca, Jingling Li, Yueting Zheng, Cac Tran, Kassandra Kasparek, Pedro Mendez, Ricky Thu, Travis Maures, Christian M. Capitini, Robert Deans, Krishanu Saha

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)

Efficient engineering of T cells to express exogenous tumor-targeting receptors such as chimeric antigen receptors (CARs) or T-cell receptors (TCRs) is a key requirement of effective adoptive cell therapy for cancer. Genome editing technologies, such

Externí odkaz: https://doaj.org/article/bbcd1d37f24e46079d2b72cfaf8b65af

Halo—A Universal Fluorescence Reader Based Threat Agent Detection Platform—A Proof of Concept Study Using SARS-CoV-2 Assays

Autor: Joseph Walish, Jason Cox, Jeremy Boone, Jennifer Stone, Nathan Henderson, Molly Maloney, Joe Ma, Jonathan Maa, Nghiem On, Konrad Petre, Bruce G. Goodwin, Shanmuga Sozhamannan, Robert Deans

Publikováno v: Frontiers in Public Health, Vol 10 (2022)

Polymerase chain reaction (PCR) remains the gold standard in disease diagnostics due to its extreme sensitivity and specificity. However, PCR tests are expensive and complex, require skilled personnel and specialized equipment to conduct the tests, a

Externí odkaz: https://doaj.org/article/f9e2b5cbb3e247f7984e11167fd07ce6

SARS-CoV-2 Variants Evolve Convergent Strategies to Remodel the Host Response

Autor: Mehdi Bouhaddou, Ann-Kathrin Reuschl, Benjamin J. Polacco, Lucy G. Thorne, Manisha R. Ummadi, Chengjin Ye, Romel Rosales, Adrian Pelin, Jyoti Batra, Gwendolyn Jang, Jiewei Xu, Jack M. Moen, Alicia L. Richards, Yuan Zhou, Bhavya Harjai, Erica Stevenson, Ajda Rojc, Roberta Ragazzini, Matthew V.X. Whelan, Wilhelm Furnon, Giuditta De Lorenzo, Vanessa Cowton, Abdullah M. Syed, Alison Ciling, Noa Deutsch, Daniel Pirak, Giulia Dowgier, Dejan Mesner, Jane L. Turner, Briana L. McGovern, M. Luis Rodriguez, Rocio Leiva-Rebollo, Alistair S. Dunham, Xiaofang Zhong, Manon Eckhardt, Andrea Fossati, Nicholas Liotta, Thomas Kehrer, Anastasija Cupic, Magda Rutkowska, Nacho Mena, Sadaf Aslam, Alyssa Hoffert, Helene Foussard, Charles Olwal, Weiqing Huang, Thomas Zwaka, John Pham, Molly Lyons, Laura Donohue, Aliesha Griffin, Rebecca Nugent, Kevin Holden, Robert Deans, Pablo Aviles, José Antonio López, José María Jimeno Doñaque, Kirsten Obernier, Jacqueline M. Fabius, Margaret Soucheray, Ruth Hüttenhain, Irwin Jungreis, Manolis Kellis, Ignacia Echeverria, Kliment Verba, Paola Bonfanti, Pedro Beltrao, Roded Sharan, Jennifer A. Doudna, Luis Martinez-Sobrido, Arvind Patel, Massimo Palmarini, Lisa Miorin, Kris White, Danielle L. Swaney, Adolfo Garcia-Sastre, Clare Jolly, Lorena Zuliani-Alvarez, Greg J. Towers, Nevan J. Krogan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1fac14fca4140ce96becc2c3766070b
https://doi.org/10.2139/ssrn.4319535

Global landscape of the host response to SARS-CoV-2 variants reveals viral evolutionary trajectories

Autor: Mehdi Bouhaddou, Ann-Kathrin Reuschl, Benjamin J. Polacco, Lucy G. Thorne, Manisha R. Ummadi, Chengjin Ye, Romel Rosales, Adrian Pelin, Jyoti Batra, Gwendolyn M. Jang, Jiewei Xu, Jack M. Moen, Alicia Richards, Yuan Zhou, Bhavya Harjai, Erica Stevenson, Ajda Rojc, Roberta Ragazzini, Matthew V.X. Whelan, Wilhelm Furnon, Giuditta De Lorenzo, Vanessa Cowton, Abdullah M. Syed, Alison Ciling, Noa Deutsch, Daniel Pirak, Giulia Dowgier, Dejan Mesner, Jane L. Turner, Briana L. McGovern, M. Luis Rodriguez, Rocio Leiva-Rebollo, Alistair S. Dunham, Xiaofang Zhong, Manon Eckhardt, Andrea Fossati, Nicholas Liotta, Thomas Kehrer, Anastasija Cupic, Magda Rutkowska, Nacho Mena, Sadaf Aslam, Alyssa Hoffert, Helene Foussard, John Pham, Molly Lyons, Laura Donahue, Aliesha Griffin, Rebecca Nugent, Kevin Holden, Robert Deans, Pablo Aviles, José Antonio López-Martín, Jose M. Jimeno, Kirsten Obernier, Jacqueline M. Fabius, Margaret Soucheray, Ruth Hüttenhain, Irwin Jungreis, Manolis Kellis, Ignacia Echeverria, Kliment Verba, Paola Bonfanti, Pedro Beltrao, Roded Sharan, Jennifer A. Doudna, Luis Martinez-Sobrido, Arvind Patel, Massimo Palmarini, Lisa Miorin, Kris White, Danielle L. Swaney, Adolfo García-Sastre, Clare Jolly, Lorena Zuliani-Alvarez, Greg J. Towers, Nevan J. Krogan

A series of SARS-CoV-2 variants of concern (VOCs) have evolved in humans during the COVID-19 pandemic—Alpha, Beta, Gamma, Delta, and Omicron. Here, we used global proteomic and genomic analyses during infection to understand the molecular responses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c8567a33da825246dd5aa0c0571375e
https://doi.org/10.1101/2022.10.19.512927

Malagasy Conostigmus (Hymenoptera: Ceraphronoidea) and the secret of scutes

Autor: István Mikó, Carolyn Trietsch, Emily L. Sandall, Matthew Jon Yoder, Heather Hines, Andrew Robert Deans

Publikováno v: PeerJ, Vol 4, p e2682 (2016)

We revise the genus Conostigmus Dahlbom 1858 occurring in Madagascar, based on data from more specimens than were examined for the latest world revision of the genus. Our results yield new information about intraspecific variability and the nature of

Externí odkaz: https://doaj.org/article/4999e76a36cc459aaf2e4e7fbc078f0f