Zobrazeno 1 - 10
of 258
pro vyhledávání: '"Robert, Damoiseaux"'
Autor:
Randilea Nichols Doyle, Vivian Yang, Yetunde I. Kayode, Robert Damoiseaux, Harry E. Taylor, Oliver I. Fregoso
Publikováno v:
Viruses, Vol 16, Iss 11, p 1783 (2024)
The latent viral reservoir represents one of the major barriers to curing HIV-1. Focus on the “kick and kill” (also called “shock and kill”) approach, in which virus expression is reactivated, and then cells producing virus are selectively de
Externí odkaz:
https://doaj.org/article/a67a2d6bf0d74c61bfdbeec191cde0be
Autor:
Yao Wang, Enrico Cortes, Ricky Huang, Jeremy Wan, Junyi Zhao, Boris Hinz, Robert Damoiseaux, Ivan Pushkarsky
Publikováno v:
SLAS Discovery, Vol 29, Iss 3, Pp 100138- (2024)
The pivotal role of myofibroblast contractility in the pathophysiology of fibrosis is widely recognized, yet HTS approaches are not available to quantify this critically important function in drug discovery. We developed, validated, and scaled-up a H
Externí odkaz:
https://doaj.org/article/9fd84433bdee47a59fce51d80d3b7468
Autor:
Einav Tayeb-Fligelman, Jeannette T. Bowler, Christen E. Tai, Michael R. Sawaya, Yi Xiao Jiang, Gustavo Garcia, Sarah L. Griner, Xinyi Cheng, Lukasz Salwinski, Liisa Lutter, Paul M. Seidler, Jiahui Lu, Gregory M. Rosenberg, Ke Hou, Romany Abskharon, Hope Pan, Chih-Te Zee, David R. Boyer, Yan Li, Daniel H. Anderson, Kevin A. Murray, Genesis Falcon, Duilio Cascio, Lorena Saelices, Robert Damoiseaux, Vaithilingaraja Arumugaswami, Feng Guo, David S. Eisenberg
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The self-assembly of the Nucleocapsid protein (NCAP) of SARS-CoV-2 is crucial for its function. Computational analysis of the amino acid sequence of NCAP reveals low-complexity domains (LCDs) akin to LCDs in other proteins known to self-asse
Externí odkaz:
https://doaj.org/article/afcfb5ca25ff4981a1a88a2f530c23e4
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Squamous cell lung cancer maintains its growth through elevated glucose consumption, but selective glucose consumption inhibitors are lacking. Here, we discovered using a high-throughput screen new compounds that block glucose consumption in
Externí odkaz:
https://doaj.org/article/e4eaa138028548aaaa47529e8164835d
Autor:
Peter J. Mullen, Gustavo Garcia, Arunima Purkayastha, Nedas Matulionis, Ernst W. Schmid, Milica Momcilovic, Chandani Sen, Justin Langerman, Arunachalam Ramaiah, David B. Shackelford, Robert Damoiseaux, Samuel W. French, Kathrin Plath, Brigitte N. Gomperts, Vaithilingaraja Arumugaswami, Heather R. Christofk
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The pandemic of COVID-19, caused by SARS-CoV-2 infection, warrants immediate investigation for therapy options. Here the authors show, using epithelial and air-liquid interface cultures, that SARS-CoV-2 hijacks host cell metabolism to facilitate vira
Externí odkaz:
https://doaj.org/article/fb48f36f0ee14f8194aa51fcf0be0cc6
Autor:
Satyesh K. Sinha, Michael Mellody, Maria Beatriz Carpio, Robert Damoiseaux, Susanne B. Nicholas
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1356 (2023)
Osteopontin (OPN) is a ubiquitously expressed protein with a wide range of physiological functions, including roles in bone mineralization, immune regulation, and wound healing. OPN has been implicated in the pathogenesis of several forms of chronic
Externí odkaz:
https://doaj.org/article/76b702ed3c0f436ab97d9577ce5340bb
Autor:
Cynthia Shu, Liubov Parfenova, Ekaterina Mokhonova, Judd R. Collado, Robert Damoiseaux, Jesus Campagna, Varghese John, Rachelle H. Crosbie
Publikováno v:
Skeletal Muscle, Vol 10, Iss 1, Pp 1-17 (2020)
Abstract Background Duchenne muscular dystrophy (DMD) is a degenerative muscle disease caused by mutations in the dystrophin gene. Loss of dystrophin prevents the formation of a critical connection between the muscle cell membrane and the extracellul
Externí odkaz:
https://doaj.org/article/398f5c9b576f48db8ca12e61e7273291
Autor:
Shen Li, Tomohiro Yokota, Ping Wang, Johanna ten Hoeve, Feiyang Ma, Thuc M. Le, Evan R. Abt, Yonggang Zhou, Rimao Wu, Maxine Nanthavongdouangsy, Abraham Rodriguez, Yijie Wang, Yen-Ju Lin, Hayato Muranaka, Mark Sharpley, Demetrios T. Braddock, Vicky E. MacRae, Utpal Banerjee, Pei-Yu Chiou, Marcus Seldin, Dian Huang, Michael Teitell, Ilya Gertsman, Michael Jung, Steven J. Bensinger, Robert Damoiseaux, Kym Faull, Matteo Pellegrini, Aldons J. Lusis, Thomas G. Graeber, Caius G. Radu, Arjun Deb
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 2 (2022)
Various populations of cells are recruited to the heart after cardiac injury, but little is known about whether cardiomyocytes directly regulate heart repair. Using a murine model of ischemic cardiac injury, we demonstrate that cardiomyocytes play a
Externí odkaz:
https://doaj.org/article/4f249dd668874f6a904b120bd8b43144
Publikováno v:
Skeletal Muscle, Vol 9, Iss 1, Pp 1-14 (2019)
Abstract Background Duchenne muscular dystrophy (DMD) is caused by loss of sarcolemma connection to the extracellular matrix. Transgenic overexpression of the transmembrane protein sarcospan (SSPN) in the DMD mdx mouse model significantly reduces dis
Externí odkaz:
https://doaj.org/article/012fd2d1fd124ae297c1513cda48de3e
Autor:
Chiara Ghezzi, Alicia Wong, Bao Ying Chen, Bernard Ribalet, Robert Damoiseaux, Peter M. Clark
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Many cancer cells have increased glucose consumption compared to normal cells, a feature that can be exploited therapeutically. Here, the authors carry out a chemical screen and identify compounds that selectively blocks glucose metabolism in non-sma
Externí odkaz:
https://doaj.org/article/2eda619824de42219eeab1b51ef3beb0