Výsledky vyhledávání - "Robert, Chênevert"

Akademický článek

tRNAGlu increases the affinity of glutamyl-tRNA synthetase for its inhibitor glutamyl-sulfamoyl-adenosine, an analogue of the aminoacylation reaction intermediate glutamyl-AMP: mechanistic and evolutionary implications.

Autor: Sébastien P Blais, Jack A Kornblatt, Xavier Barbeau, Guillaume Bonnaure, Patrick Lagüe, Robert Chênevert, Jacques Lapointe

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0121043 (2015)

For tRNA-dependent protein biosynthesis, amino acids are first activated by aminoacyl-tRNA synthetases (aaRSs) yielding the reaction intermediates aminoacyl-AMP (aa-AMP). Stable analogues of aa-AMP, such as aminoacyl-sulfamoyl-adenosines, inhibit the

Externí odkaz: https://doaj.org/article/3b1d561ac2e54987ae808045ca1ea8dc

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Inhibition ofHelicobacter pyloriGlu-tRNAGlnamidotransferase by novel analogues of the putative transamidation intermediate

Autor: Paul H. Roy, Sébastien P. Blais, Christian Balg, Normand Voyer, Robert Chênevert, Jacques Lapointe, Halim Maaroufi, Nancy Messier, Van Hau Pham, François Otis

Publikováno v: FEBS Letters. 590:3335-3345

Glutaminyl-tRNAGln in Helicobacter pylori is formed by an indirect route requiring a noncanonical glutamyl-tRNA synthetase and a tRNA-dependent heterotrimeric amidotransferase (AdT) GatCAB. Widespread use of this pathway among prominent human pathoge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a144e3dc88691cfbc941e34dac56595
https://doi.org/10.1002/1873-3468.12380

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Chemoenzymatic enantioselective synthesis of 2-substituted glycerol derivatives

Autor: Annie Michaud, Mélanie Bolduc, Jérôme Bergeron, Nicholas Pelchat, Robert Chênevert, Pierre Morin, Mohammed Dasser

Publikováno v: Tetrahedron: Asymmetry. 23:428-433

2-Substituted glycerol derivatives 4a–g were resolved by acylation with vinyl butyrate in the presence of lipases in organic media. The reverse reaction, the enzymatic hydrolysis of the corresponding butyrates 5a–g , was also highly stereoselecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::691dcb1d4376e21e2ca82865b882f71c
https://doi.org/10.1016/j.tetasy.2012.04.001

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Chemoenzymatic enantioselective synthesis of 7-azabicyclo[2.2.1]heptane derivatives

Autor: Michel Fila, Pierre Morin, Carine Lévesque, Annie Michaud, Nicholas Pelchat, Robert Chênevert

Publikováno v: Tetrahedron: Asymmetry. 22:819-822

The enantioselective acylation (desymmetrization) of meso -7-azabicyclo[2.2.1]heptanediol 2 by vinyl acetate in the presence of Candida antarctica lipase B gave the corresponding (1 R ,2 R ,3 S ,4 S )-monoester 4 in high enantiomeric purity (ee ⩾ 9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::803fec430f45c797efc4c26152b8cf22
https://doi.org/10.1016/j.tetasy.2011.05.016

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Lipase-mediated enantioselective acylation of alcohols with functionalized vinyl esters: acyl donor tolerance and applications

Autor: Pierre Morin, Robert Chênevert, Nicholas Pelchat

Publikováno v: Tetrahedron: Asymmetry. 20:1191-1196

Enzymatic acylation is commonly used for the kinetic resolution of alcohols and amines. The simple acyl group introduced during the enzymatic reaction is usually removed or replaced by another group. Retention of more complex acyl moieties as part of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::98e5c2204fb10e961e27ca3804f9381f
https://doi.org/10.1016/j.tetasy.2009.03.027

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Agarose gel facilitates enzyme crystal soaking with a ligand analog

Autor: Robert Chênevert, Abel Moreno, Richard Giegé, Kaouthar Dhouib, Claude Sauter, Bernard Lorber, Anne Théobald-Dietrich, Christian Balg

Publikováno v: Journal of Applied Crystallography. 42:279-283

Orthorhombic crystals of the enzyme aspartyl-tRNA synthetase (AspRS) were prepared in agarose gel, a chemical alternative to microgravity or nano-volume drops. Besides providing a convection-free medium, the network of the polysaccharide improved the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d425fcbd93cd89c487dde9190671d702
https://doi.org/10.1107/s0021889809003446

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Kinetic and mechanistic characterization of Mycobacterium tuberculosis glutamyl-tRNA synthetase and determination of its oligomeric structure in solution

Autor: Rachele Morosi, Maxim V. Petoukhov, Stefano Paravisi, Gianluca Fumagalli, Stéphane Bernier, Maria A. Vanoni, Milena Riva, Bruno Curti, Dmitri I. Svergun, Peter V. Konarev, Robert Chênevert, Paola Morandi

Publikováno v: FEBS Journal. 276:1398-1417

Mycobacterium tuberculosis glutamyl–tRNA synthetase (Mt-GluRS), encoded by Rv2992c, was overproduced in Escherichia coli cells, and purified to homogeneity. It was found to be similar to the other well-characterized GluRS, especially the E. coli en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb0dad8e4f4057a4c50de321a86dbbd2
https://doi.org/10.1111/j.1742-4658.2009.06880.x

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Enzymatic desymmetrization of pyrrolidine and pyrroline derivatives

Autor: Robert Chênevert, Frédéric Jacques, Pascall Giguère, Mohammed Dasser

Publikováno v: Tetrahedron: Asymmetry. 19:1333-1338

The enzymatic desymmetrization of various meso-N-Boc-2,5-cis-disubstituted pyrrolidines and pyrrolines compounds by ester hydrolysis or transesterification provided the corresponding monoesters in high enantiomeric excess.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9afc0f726822434c7c1e2465fc0649fa
https://doi.org/10.1016/j.tetasy.2008.05.022

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