BET inhibition decreases HMGCS2 and sensitizes resistant pancreatic tumors to gemcitabine

Autor: Miller, Aubrey L., Fehling, Samuel C., Vance, Rebecca B., Chen, Dongquan, Brown, Eric Josh, Hossain, M. Iqbal, Heard, Eric O., Andrabi, Shaida A., Wang, Hengbin, Yang, Eddy S., Buchsbaum, Donald J., van Waardenburg, Robert C.A.M., Bellis, Susan L., Yoon, Karina J.

Publikováno v: In Cancer Letters 28 June 2024 592

Zymolyase Treatment of Saccharomyces cerevisiae Affects Cellular Proteins and Degrades Tyrosyl-DNA Phosphodiesterase I.

Autor: Brettrager, Evan J., Frederick, Aaron J., van Waardenburg, Robert C.A.M.

Publikováno v: DNA & Cell Biology; Jul2024, Vol. 43 Issue 7, p353-361, 9p

The BET inhibitor JQ1 attenuates double-strand break repair and sensitizes models of pancreatic ductal adenocarcinoma to PARP inhibitorsResearch in context

Autor: Aubrey L. Miller, Samuel C. Fehling, Patrick L. Garcia, Tracy L. Gamblin, Leona N. Council, Robert C.A.M. van Waardenburg, Eddy S. Yang, James E. Bradner, Karina J. Yoon

Publikováno v: EBioMedicine, Vol 44, Iss , Pp 419-430 (2019)

Background: DNA repair deficiency accumulates DNA damage and sensitizes tumor cells to PARP inhibitors (PARPi). Based on our observation that the BET inhibitor JQ1 increases levels of DNA damage, we evaluated the efficacy of JQ1 + the PARPi olaparib

Externí odkaz: https://doaj.org/article/06329e4890dc457f95f1890ebe29c231

Continuation sheaves in dynamics: Sheaf cohomology and bifurcation

Autor: K. Alex Dowling, William D. Kalies, Robert C.A.M. Vandervorst

Publikováno v: Dowling, K A, Kalies, W D & Vandervorst, R C A M 2023, ' Continuation sheaves in dynamics: Sheaf cohomology and bifurcation ', Journal of Differential Equations, vol. 367, pp. 124-198 . https://doi.org/10.1016/j.jde.2023.04.041
Journal of Differential Equations, 367, 124-198. Academic Press Inc.

Algebraic structures such as the lattices of attractors, repellers, and Morse representations provide a computable description of global dynamics. In this paper, a sheaf-theoretic approach to their continuation is developed. The algebraic structures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ffaec00208bb16d90af0116426b5a9
https://research.vu.nl/en/publications/697ad782-8e7f-4179-97c0-ce57e2e3f29e

Figure S4 from JQ1 Induces DNA Damage and Apoptosis, and Inhibits Tumor Growth in a Patient-Derived Xenograft Model of Cholangiocarcinoma

Autor: Karina J. Yoon, Eddy S. Yang, James E. Bradner, Robert C.A.M. van Waardenburg, Xiangqin Cui, Joseph H. Richardson, Sushanth Reddy, Marty J. Heslin, J. Pablo Arnoletti, John D. Christein, Leona N. Council, Tracy L. Gamblin, Aubrey L. Miller, Patrick L. Garcia

Immunoblot analysis showing that JQ1 downregulates TEK, Chk1, MSH2 and LCK expression in CCA2 tumors, but not in CCA1 tumors.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7a452940d6358b754c0626b806e616c
https://doi.org/10.1158/1535-7163.22505407