Výsledky vyhledávání - "Robert, Blomgran"

Akademický článek

Macrophage-derived extracellular vesicles from Ascaris lumbricoides antigen exposure enhance Mycobacterium tuberculosis growth control, reduce IL-1β, and contain miR-342-5p, miR-516b-5p, and miR-570-3p that regulate PI3K/AKT and MAPK signaling pathways

Autor: Giggil Pushpamithran, Robert Blomgran

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

BackgroundHelminth coinfection with tuberculosis (TB) can alter the phenotype and function of macrophages, which are the major host cells responsible for controlling Mycobacterium tuberculosis (Mtb). However, it is not known whether helminth infectio

Externí odkaz: https://doaj.org/article/54b84f00a8f7409ebad23c35104a4214

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Akademický článek

No impact of helminth coinfection in patients with smear positive tuberculosis on immunoglobulin levels using a novel method measuring Mycobacterium tuberculosis-specific antibodies

Autor: Giggil Pushpamithran, Camilla Skoglund, Fanny Olsson, Melissa Méndez-Aranda, Thomas Schön, Mårten Segelmark, Olle Stendahl, Robert H. Gilman, Robert Blomgran

Publikováno v: Allergy, Asthma & Clinical Immunology, Vol 19, Iss 1, Pp 1-9 (2023)

Abstract Helminth/tuberculosis (TB)-coinfection can reduce cell-mediated immunity against Mycobacterium tuberculosis (Mtb) and increase disease severity, although the effects are highly helminth species dependent. Mtb have long been ranked as the num

Externí odkaz: https://doaj.org/article/9a6ebaf1d3e9476daf3ffce17a08e49d

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Akademický článek

Helminth species-specific effects on IFN-γ producing T cells during active and latent tuberculosis.

Autor: Amare Kiflie, Gezahegn Bewket, Fitsumbrhan Tajebe, Ebba Abate, Thomas Schӧn, Robert Blomgran

Publikováno v: PLoS Neglected Tropical Diseases, Vol 17, Iss 1, p e0011094 (2023)

BackgroundInterferon-γ (IFN-γ) is a key cytokine inducing protective immune responses during tuberculosis (TB) infection. Helminth-induced immune responses may affect IFN-γ production by T cells, although its connection with disease severity and i

Externí odkaz: https://doaj.org/article/c1b1a6e2e9e44ccdb87408b5140e042a

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Akademický článek

Helminth species dependent effects on Th1 and Th17 cytokines in active tuberculosis patients and healthy community controls.

Autor: Gezahegn Bewket, Amare Kiflie, Fitsumbrhan Tajebe, Ebba Abate, Thomas Schön, Robert Blomgran

Publikováno v: PLoS Neglected Tropical Diseases, Vol 16, Iss 8, p e0010721 (2022)

Despite that the impact of different helminth species is not well explored, the current dogma states that helminths affect the Th1/Th2 balance which in turn affects the risk of tuberculosis (TB) reactivation and severity of disease. We investigated t

Externí odkaz: https://doaj.org/article/e0223949bd6b4f308d20571cdaefcfd2

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Akademický článek

Helminth Antigen Exposure Enhances Early Immune Control of Mycobacterium tuberculosis in Monocytes and Macrophages

Autor: Shambhuprasad Kotresh Togarsimalemath, Giggil Pushpamithran, Thomas Schön, Olle Stendahl, Robert Blomgran

Publikováno v: Journal of Innate Immunity, Pp 1-16 (2020)

Helminth and Mycobacterium tuberculosis (Mtb) coinfection is common and suggested to influence the risk of developing active tuberculosis (TB). It is known that helminths in contrast to TB induce a strong Th2 response in the host. However, the direct

Externí odkaz: https://doaj.org/article/1c5c9fdc3add496595f480ee86810bb8

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Akademický článek

Helminth species specific expansion and increased TNF-alpha production of non-classical monocytes during active tuberculosis.

Autor: Gezahegn Bewket, Amare Kiflie, Ebba Abate, Olle Stendahl, Thomas Schön, Robert Blomgran

Publikováno v: PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009194 (2021)

Both Mycobacterium tuberculosis infection and helminths may affect innate immune mechanisms such as differential effects on monocytes towards the non-classical and intermediate subsets that favor bacterial persistence. Our aim, was to investigate hel

Externí odkaz: https://doaj.org/article/fad2f5adb4694c37ba8fd8f55938cb72

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Akademický článek

Species dependent impact of helminth-derived antigens on human macrophages infected with Mycobacterium tuberculosis: Direct effect on the innate anti-mycobacterial response.

Autor: Naomi Aira, Anna-Maria Andersson, Susmita K Singh, Derek M McKay, Robert Blomgran

Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005390 (2017)

BACKGROUND:In countries with a high prevalence of tuberculosis there is high coincident of helminth infections that might worsen disease outcome. While Mycobacterium tuberculosis (Mtb) gives rise to a pro-inflammatory Th1 response, a Th2 response is

Externí odkaz: https://doaj.org/article/b89803ca03ad4b9dab897fd18e31c546

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