Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Robert, Blelloch"'
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-26 (2023)
Abstract Background Enhancers are essential in defining cell fates through the control of cell-type-specific gene expression. Enhancer activation is a multi-step process involving chromatin remodelers and histone modifiers including the monomethylati
Externí odkaz:
https://doaj.org/article/54502e8e97744ae19f030b09cccac780
Autor:
Brian DeVeale, Leqian Liu, Ryan Boileau, Jennifer Swindlehurst-Chan, Bryan Marsh, Jacob W. Freimer, Adam Abate, Robert Blelloch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Somatic cells display phasic gene expression with compartmentalized gene expression during the cell cycle, while pluripotent cells lack phasic expression. Here, the authors describe a pathway linking microRNA regulation of the G1/S restriction point
Externí odkaz:
https://doaj.org/article/2a576b79637b4524bec7aa38438e02b9
Publikováno v:
eLife, Vol 11 (2022)
The human placenta contains two specialized regions: the villous chorion where gases and nutrients are exchanged between maternal and fetal blood, and the smooth chorion (SC) which surrounds more than 70% of the developing fetus but whose cellular co
Externí odkaz:
https://doaj.org/article/d5f9cbc7ed4844d8b89e0495a4ffa5a9
Autor:
Delphine M. Depierreux, Jens Kieckbusch, Norman Shreeve, Delia A. Hawkes, Bryan Marsh, Robert Blelloch, Andrew Sharkey, Francesco Colucci
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Reproductive immunology has moved on from the classical Medawar question of 60 years ago “why doesn’t the mother reject the fetus?”. Looking beyond fetal-maternal tolerance, modern reproductive immunology focuses on how the maternal immune syst
Externí odkaz:
https://doaj.org/article/2edb5458378c4b799805d7a075f7f2ab
Autor:
Xin Zhou, Gopika G. Nair, Holger A. Russ, Cassandra D. Belair, Mei-Lan Li, Mayya Shveygert, Matthias Hebrok, Robert Blelloch
Publikováno v:
Stem Cell Reports, Vol 14, Iss 1, Pp 9-20 (2020)
Summary: Differentiation of human embryonic stem cells into pancreatic β cells holds great promise for the treatment of diabetes. Recent advances have led to the production of glucose-responsive insulin-secreting cells in vitro, but resulting cells
Externí odkaz:
https://doaj.org/article/24b90ec89952421982da2c90744377f2
Autor:
Lisa L Kirkemo, Susanna K Elledge, Jiuling Yang, James R Byrnes, Jeff E Glasgow, Robert Blelloch, James A Wells
Publikováno v:
eLife, Vol 11 (2022)
Characterization of cell surface proteome differences between cancer and healthy cells is a valuable approach for the identification of novel diagnostic and therapeutic targets. However, selective sampling of surface proteins for proteomics requires
Externí odkaz:
https://doaj.org/article/2788c63fd6b14a199fa51148956ffdd4
Autor:
Bryan Marsh, Robert Blelloch
Publikováno v:
eLife, Vol 9 (2020)
The placenta is the interface between mother and fetus in all eutherian species. However, our understanding of this essential organ remains incomplete. A substantial challenge has been the syncytial cells of the placenta, which have made dissociation
Externí odkaz:
https://doaj.org/article/b27b1e0967304722a1df367c3379cf96
Autor:
Gennaro Gambardella, Annamaria Carissimo, Amy Chen, Luisa Cutillo, Tomasz J. Nowakowski, Diego di Bernardo, Robert Blelloch
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
MicroRNAs can posttranscriptionally repress multiple targets in a cell population. Here the authors use single-cell sequencing to investigate the effects of an individual miRNA on transcriptional heterogeneity and gene co-expression
Externí odkaz:
https://doaj.org/article/915b924b7b1a49c5860ec77d7652288d
Autor:
Robert Blelloch, Emmanuelle Passegué, Scott C. Kogan, Haijiang Lin, Keegan Q. Barry-Holson, Cassandra D. Belair, Deepa Subramanyam
Supplementary Figures 1-7 from PML-RARα and Dnmt3a1 Cooperate in vivo to Promote Acute Promyelocytic Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35bda3dd13e9777c651d3c4fd9b467fd
https://doi.org/10.1158/0008-5472.22382241
https://doi.org/10.1158/0008-5472.22382241
Autor:
Robert Blelloch, Emmanuelle Passegué, Scott C. Kogan, Haijiang Lin, Keegan Q. Barry-Holson, Cassandra D. Belair, Deepa Subramanyam
The PML-RARα oncogene is the central effector of acute promyelocytic leukemia (APL). PML-RARα physically interacts with epigenetic-modifying enzymes including DNA methyltransferases (Dnmt) to suppress critical downstream targets. Here, we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f76f58a47ea9a06dfafd568be1f6436
https://doi.org/10.1158/0008-5472.c.6500139.v1
https://doi.org/10.1158/0008-5472.c.6500139.v1