Zobrazeno 1 - 10
of 1 093
pro vyhledávání: '"Robert, A Holt"'
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract Current tools for functionally profiling T cell receptors with respect to cytotoxic potency and cross-reactivity are hampered by difficulties in establishing model systems to test these proteins in the contexts of different HLA alleles and a
Externí odkaz:
https://doaj.org/article/7e661a7f9e84401eafd2a999f6bce319
Autor:
Joel Kidman, Rachael M. Zemek, John-William Sidhom, Debora Correa, Nicola Principe, Fezaan Sheikh, Vanessa S. Fear, Catherine A. Forbes, Abha Chopra, Louis Boon, Ayham Zaitouny, Emma de Jong, Robert A. Holt, Matt Jones, Michael J. Millward, Timo Lassmann, Alistair R.R. Forrest, Anna K. Nowak, Mark Watson, Richard A. Lake, W. Joost Lesterhuis, Jonathan Chee
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
ABSTRACTImmune checkpoint therapy (ICT) causes durable tumour responses in a subgroup of patients, but it is not well known how T cell receptor beta (TCRβ) repertoire dynamics contribute to the therapeutic response. Using murine models that exclude
Externí odkaz:
https://doaj.org/article/f60545e051804f9796499b61db90824e
Autor:
Brett R. Lane, Amy E. Kendig, Christopher M. Wojan, Ashish Adhikari, Michelle A. Jusino, Nicholas Kortessis, Margaret W. Simon, Robert D. Holt, Matthew E. Smith, Keith Clay, S. Luke Flory, Philip F. Harmon, Erica M. Goss
Publikováno v:
Phytobiomes Journal, Vol 7, Iss 2, Pp 198-207 (2023)
Invasive plants, which cause substantial economic and ecological impacts, acquire both pathogens and beneficial microbes in their introduced ranges. Communities of fungal endophytes are known to mediate impacts of pathogens on plant fitness but few s
Externí odkaz:
https://doaj.org/article/00187223bcdf4d0d9994907132dcc0bc
Publikováno v:
Forests, Vol 15, Iss 8, p 1308 (2024)
To predict the potential success of an invading non-native species, it is important to understand its dynamics and interactions with native species in the early stages of its invasion. In spatially implicit models, mathematical stability criteria are
Externí odkaz:
https://doaj.org/article/6fb13afdecf94c6182c32ae9ad91fe4a
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background Sequence verification is essential for plasmids used as critical reagents or therapeutic products. Typically, high-quality plasmid sequence is achieved through capillary-based Sanger sequencing, requiring customized sets of primer
Externí odkaz:
https://doaj.org/article/dc10f57d9bd44154b770c27724b9f67e
Autor:
Craig M. Rive, Eric Yung, Lisa Dreolini, Scott D. Brown, Christopher G. May, Daniel J. Woodsworth, Robert A. Holt
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 4-14 (2022)
Anti-CD19 chimeric antigen receptor (CAR)-T therapy for B cell malignancies has shown clinical success, but a major limitation is the logistical complexity and high cost of manufacturing autologous cell products. If engineered for improved safety, di
Externí odkaz:
https://doaj.org/article/e9e2841271204775972c31c9bc2c6647
Publikováno v:
Ecology and Evolution, Vol 13, Iss 7, Pp n/a-n/a (2023)
Abstract Food has long been known to perform dual functions of nutrition and medicine, but mounting evidence suggests that complex host‐pathogen dynamics can emerge along continuous resource gradients. Empirical examples of nonmonotonic responses o
Externí odkaz:
https://doaj.org/article/0af42384e2144088a5961f5b0497d0af
Autor:
Kristina J Weaver, Sonakshi Raju, Rachel A Rucker, Tuhin Chakraborty, Robert A Holt, Scott D Pletcher
Publikováno v:
eLife, Vol 12 (2023)
Hunger is a motivational drive that promotes feeding, and it can be generated by the physiological need to consume nutrients as well as the hedonic properties of food. Brain circuits and mechanisms that regulate feeding have been described, but which
Externí odkaz:
https://doaj.org/article/9400d62edf3b4053b15f60fe7d981d3c
Autor:
Laura M. Williamson, Craig M. Rive, Daniela Di Francesco, Emma Titmuss, Hye-Jung E. Chun, Scott D. Brown, Katy Milne, Erin Pleasance, Anna F. Lee, Stephen Yip, Daniel G. Rosenbaum, Martin Hasselblatt, Pascal D. Johann, Marcel Kool, Melissa Harvey, David Dix, Daniel J. Renouf, Robert A. Holt, Brad H. Nelson, Martin Hirst, Steven J. M. Jones, Janessa Laskin, Shahrad R. Rassekh, Rebecca J. Deyell, Marco A. Marra
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-12 (2021)
Abstract Poorly differentiated chordoma (PDC) is a recently recognized subtype of chordoma characterized by expression of the embryonic transcription factor, brachyury, and loss of INI1. PDC primarily affects children and is associated with a poor pr
Externí odkaz:
https://doaj.org/article/bbebf60a317a4ddd91c243c4098f13a6
Autor:
Natasha Kekre, Kevin A. Hay, John R. Webb, Ranjeeta Mallick, Miruna Balasundaram, Mhairi K. Sigrist, Anne-Marie Clement, Julie S. Nielsen, Jennifer Quizi, Eric Yung, Scott D. Brown, Lisa Dreolini, Daniel D. Waller, Julian Smazynski, Nicole S. Gierc, Bianca C. Loveless, Kayla Clark, Tyler Dyer, Richard Hogg, Leah McCormick, Michael Gignac, Shanti Bell, D. Maria Chapman, David Bond, Siao Yong, Rachel Fung, Heather M. Lockyer, Victoria Hodgson, Catherine Murphy, Ana Subramanian, Evelyn Wiebe, Piriya Yoganathan, Liana Medynski, Dominique C. Vaillan, Alice Black, Sheryl McDiarmid, Michael Kennah, Linda Hamelin, Kevin Song, Sujaatha Narayanan, Judith A. Rodrigo, Stefany Dupont, Terry Hawrysh, Justin Presseau, Kednapa Thavorn, Manoj M. Lalu, Dean A. Fergusson, John C. Bell, Harold Atkins, Brad H. Nelson, Robert A. Holt
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Access to commercial CD19 CAR-T cells remains limited even in wealthy countries like Canada due to clinical, logistical, and financial barriers related to centrally manufactured products. We created a non-commercial academic platform for end-to-end m
Externí odkaz:
https://doaj.org/article/ba9bb5ccb69a4646aee78f29aa8e0137