Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Robby M, Zachariah"'
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 8, p 1845 (2019)
Methyl CpG binding protein-2 (MeCP2) isoforms (E1 and E2) are important epigenetic regulators in brain cells. Accordingly, MeCP2 loss- or gain-of-function mutation causes neurodevelopmental disorders, including Rett syndrome (RTT), MECP2 duplication
Externí odkaz:
https://doaj.org/article/d7f136ad28c64ac9b4d1fd967bf2d291
Autor:
Hassan eMarzban, Marc R. Del Bigio, Javad eAlizadeh, Saeid eGhavami, Robby M. Zachariah, Mojgan eRastegar
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 8 (2015)
The mammalian cerebellum is located in the posterior cranial fossa and is critical for motor coordination and non-motor functions including cognitive and emotional processes. The anatomical structure of cerebellum is distinct with a three-layered cor
Externí odkaz:
https://doaj.org/article/545c86b152004e879a0ee7279606f378
Autor:
Carl O. Olson, Robby M. Zachariah, Geoffrey G. Hicks, Wayne Xu, Romina D. Levy, Aaron MacAulay, James R. Davie, Kyle Curtis, Marjorie Buist, Shayan Amiri, Mojgan Rastegar, Vichithra R. B. Liyanage
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Scientific Reports
Scientific Reports
We have previously reported the deregulatory impact of ethanol on global DNA methylation of brain-derived neural stem cells (NSC). Here, we conducted a genome-wide RNA-seq analysis in differentiating NSC exposed to different modes of ethanol exposure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa709a92ef5bb0aa0aa4cfe884c2607
http://link.springer.com/article/10.1038/s41598-018-36059-y
http://link.springer.com/article/10.1038/s41598-018-36059-y
Autor:
Carl O Olson, Robby M Zachariah, Chinelo D Ezeonwuka, Vichithra R B Liyanage, Mojgan Rastegar
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90645 (2014)
MeCP2 is a critical epigenetic regulator in brain and its abnormal expression or compromised function leads to a spectrum of neurological disorders including Rett Syndrome and autism. Altered expression of the two MeCP2 isoforms, MeCP2E1 and MeCP2E2
Externí odkaz:
https://doaj.org/article/047f4ba6b42345e188dbaa95e4f78880
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49763 (2012)
Rett Syndrome (RTT) is a severe neurological disorder in young females, and is caused by mutations in the X-linked MECP2 gene. MECP2/Mecp2 gene encodes for two protein isoforms; MeCP2E1 and MeCP2E2 that are identical except for the N-terminus region
Externí odkaz:
https://doaj.org/article/80e9475b280a4978b3e7791de294ed18
Autor:
Robby M. Zachariah, Vichithra R. B. Liyanage, Albert E. Chudley, Kyle Curtis, Mojgan Rastegar
Publikováno v:
Current topics in medicinal chemistry. 17(7)
Prenatal alcohol (ethanol) exposure (PAE) is the underlying cause for a variety of birth defects and neurodevelopmental deficits referred to as “Fetal Alcohol Spectrum Disorders (FASD)”. The more visible phenotypes caused by PAE include growth re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b191f46c5999a3306c49144024c65291
https://pubmed.ncbi.nlm.nih.gov/27086780
https://pubmed.ncbi.nlm.nih.gov/27086780
Publikováno v:
Experimental neurology. 265
Methyl CpG Binding Protein 2 (MeCP2) is an important epigenetic factor in the brain. MeCP2 expression is affected by different environmental insults including alcohol exposure. Accumulating evidence supports the role of aberrant MeCP2 expression in e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c4210a8922460b18d326466f1381d4
https://pubmed.ncbi.nlm.nih.gov/25620416
https://pubmed.ncbi.nlm.nih.gov/25620416
Publikováno v:
Molecular Autism
Background Aberrant MeCP2 expression in brain is associated with neurodevelopmental disorders including autism. In the brain of stressed mouse and autistic human patients, reduced MeCP2 expression is correlated with Mecp2/MECP2 promoter hypermethylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef1787704aa60c9b47640b11cdf2e7bf
https://doi.org/10.1186/2040-2392-4-46
https://doi.org/10.1186/2040-2392-4-46
Autor:
Vichithra R. B. Liyanage, Benjamin A. Barber, Carl O. Olson, Robby M. Zachariah, Melissa A.G. Bailey, Mojgan Rastegar
Publikováno v:
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 195(5)
Central nervous system development is controlled by highly conserved homeoprotein transcription factors including HOX and TALE (Three Amino acid Loop Extension). TALE proteins are primarily known as HOX-cofactors and play key roles in cell proliferat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc94991ee3d998807a80da344a7dc6d0
https://pubmed.ncbi.nlm.nih.gov/23756022
https://pubmed.ncbi.nlm.nih.gov/23756022
Autor:
Robby M. Zachariah, Mojgan Rastegar
Publikováno v:
Neural Plasticity, Vol 2012 (2012)
Neural Plasticity
Neural Plasticity
Epigenetics refer to inheritable changes beyond DNA sequence that control cell identity and morphology. Epigenetics play key roles in development and cell fate commitments and highly impact the etiology of many human diseases. A well-known link betwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d136a003a07fb28eeb874a67065f9bda
https://doi.org/10.1155/2012/415825
https://doi.org/10.1155/2012/415825
