Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design.

Autor: Quinn TR; Early TDE Discovery, Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Giblin KA; Early TDE Discovery, Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, U.K., Thomson C; Early TDE Discovery, Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, U.K., Boerth JA; Early TDE Discovery, Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Bommakanti G; Early TDE Discovery, Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Braybrooke E; Early TDE Discovery, Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, U.K., Chan C; Early TDE Discovery, Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, U.K., Chinn AJ; Early TDE Discovery, Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Code E; Discovery Sciences, R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Cui C; Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China., Fan Y; Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China., Grimster NP; Early TDE Discovery, Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Kohara K; Early TDE Discovery, Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, U.K., Lamb ML; Early TDE Discovery, Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Ma L; Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China., Mfuh AM; Early TDE Discovery, Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Robb GR; Early TDE Discovery, Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, U.K., Robbins KJ; Early TDE Discovery, Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Schimpl M; Discovery Sciences, R&D, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, U.K., Tang H; Discovery Sciences, R&D, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, U.K., Ware J; Discovery Sciences, R&D, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, U.K., Wrigley GL; Early TDE Discovery, Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, U.K., Xue L; Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China., Zhang Y; Early TDE Discovery, Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Zhu H; Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China., Hughes SJ; Early TDE Discovery, Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, U.K.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Aug 22; Vol. 67 (16), pp. 14210-14233. Date of Electronic Publication: 2024 Aug 12.

ASO Author Reflections: A Role for Extended VTE Prophylaxis After Neoadjuvant Therapy and Distal Pancreatectomy for Pancreatic Adenocarcinoma.

Autor: Robbins KJ; Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA., Hawkins WG; Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA. hawkinwi@musc.edu.; MUSC, Hollings Cancer Center, Charelston, SC, USA. hawkinwi@musc.edu.

Publikováno v: Annals of surgical oncology [Ann Surg Oncol] 2024 May; Vol. 31 (5), pp. 2965-2966. Date of Electronic Publication: 2024 Jan 12.

Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors.

Autor: Mfuh AM; Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Boerth JA; Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Bommakanti G; Discovery Sciences, R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Chan C; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Chinn AJ; Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Code E; Discovery Sciences, R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Fricke PJ; Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Giblin KA; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Gohlke A; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Hansel C; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Hariparsad N; Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Hughes SJ; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Jin M; Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Kantae V; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Kavanagh SL; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Lamb ML; Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Lane J; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Moore R; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Puri T; Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Quinn TR; Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Reddy I; Discovery Sciences, R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Robb GR; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Robbins KJ; Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Gancedo Rodrigo M; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K.; Isomorphic Laboratories, 280 Bishopsgate, London EC2M 4RB, U.K., Schimpl M; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Singh B; Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Singh M; Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Tang H; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Thomson C; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Walsh JJ; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Ware J; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Watson IDG; Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Ye MW; Discovery Sciences, R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Wrigley GL; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Zhang AX; Discovery Sciences, R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Zhang Y; Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Grimster NP; Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Jan 25; Vol. 67 (2), pp. 1500-1512. Date of Electronic Publication: 2024 Jan 16.

Autologous humanized PDX modeling for immuno-oncology recapitulates features of the human tumor microenvironment.

Autor: Chiorazzi M; Department of Internal Medicine, Section of Medical Oncology, Yale School of Medicine, New Haven, Connecticut, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA., Martinek J; Jackson Laboratory - Farmington, Farmington, Connecticut, USA., Krasnick B; Alvin J Siteman Cancer Center, St Louis, Missouri, USA.; Department of Surgery, Washington University School of Medicine in Saint Louis, St Louis, Missouri, USA., Zheng Y; Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA., Robbins KJ; Alvin J Siteman Cancer Center, St Louis, Missouri, USA.; Department of Surgery, Washington University School of Medicine in Saint Louis, St Louis, Missouri, USA., Qu R; Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA.; Department of Pathology, Yale School of Medicine, New Haven, Connecticut, USA., Kaufmann G; Department of Internal Medicine, Section of Medical Oncology, Yale School of Medicine, New Haven, Connecticut, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA., Skidmore Z; Alvin J Siteman Cancer Center, St Louis, Missouri, USA.; Department of Surgery, Washington University School of Medicine in Saint Louis, St Louis, Missouri, USA., Juric M; Department of Internal Medicine, Section of Medical Oncology, Yale School of Medicine, New Haven, Connecticut, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA., Henze LA; Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA., Brösecke F; Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA., Adonyi A; Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA., Zhao J; Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA.; Department of Pathology, Yale School of Medicine, New Haven, Connecticut, USA., Shan L; Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA., Sefik E; Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA., Mudd J; Alvin J Siteman Cancer Center, St Louis, Missouri, USA.; Department of Surgery, Washington University School of Medicine in Saint Louis, St Louis, Missouri, USA., Bi Y; Alvin J Siteman Cancer Center, St Louis, Missouri, USA.; Department of Surgery, Washington University School of Medicine in Saint Louis, St Louis, Missouri, USA., Goedegebuure SP; Alvin J Siteman Cancer Center, St Louis, Missouri, USA.; Department of Surgery, Washington University School of Medicine in Saint Louis, St Louis, Missouri, USA., Griffith M; Alvin J Siteman Cancer Center, St Louis, Missouri, USA.; Department of Surgery, Washington University School of Medicine in Saint Louis, St Louis, Missouri, USA., Griffith O; Alvin J Siteman Cancer Center, St Louis, Missouri, USA.; Department of Surgery, Washington University School of Medicine in Saint Louis, St Louis, Missouri, USA., Oyedeji A; Alvin J Siteman Cancer Center, St Louis, Missouri, USA.; Department of Surgery, Washington University School of Medicine in Saint Louis, St Louis, Missouri, USA., Fertuzinhos S; Bioinformatics Support Program, Cushing/Whitney Medical Library, Yale School of Medicine, New Haven, Connecticut, USA., Garcia-Milian R; Bioinformatics Support Program, Cushing/Whitney Medical Library, Yale School of Medicine, New Haven, Connecticut, USA., Boffa D; Department of Surgery, Section of Thoracic Oncology, Yale School of Medicine, New Haven, Connecticut, USA., Detterbeck F; Department of Surgery, Section of Thoracic Oncology, Yale School of Medicine, New Haven, Connecticut, USA., Dhanasopon A; Department of Surgery, Section of Thoracic Oncology, Yale School of Medicine, New Haven, Connecticut, USA., Blasberg J; Department of Surgery, Section of Thoracic Oncology, Yale School of Medicine, New Haven, Connecticut, USA., Judson B; Department of Surgery, Section of Otolaryngology, Yale School of Medicine, New Haven, Connecticut, USA., Gettinger S; Department of Internal Medicine, Section of Medical Oncology, Yale School of Medicine, New Haven, Connecticut, USA., Politi K; Department of Internal Medicine, Section of Medical Oncology, Yale School of Medicine, New Haven, Connecticut, USA., Kluger Y; Department of Pathology, Yale School of Medicine, New Haven, Connecticut, USA., Palucka K; Jackson Laboratory - Farmington, Farmington, Connecticut, USA., Fields RC; Alvin J Siteman Cancer Center, St Louis, Missouri, USA.; Department of Surgery, Washington University School of Medicine in Saint Louis, St Louis, Missouri, USA., Flavell RA; Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA richard.flavell@yale.edu.; Howard Hughes Medical Institute, New York, New York, USA.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2023 Jul; Vol. 11 (7).

An asymptomatic swelling of the hard palatal mucosa.

Autor: Vargo RJ; Oral and Maxillofacial Pathology Specialty Care Unit, A.T. Still University-Missouri School of Dentistry & Oral Health, St. Louis, MO, USA; Department of Otolaryngology-Head and Neck Surgery, Saint Louis University School of Medicine, St. Louis, MO, USA; Department of Pathology, Anatomic Pathology, Saint Louis University School of Medicine, St. Louis, MO, USA. Electronic address: Richardvargo@atsu.edu., Robbins KJ; Department of Pathology, Anatomic Pathology, Saint Louis University School of Medicine, St. Louis, MO, USA., Stoeckel DC; Department of Pathology, Anatomic Pathology, Saint Louis University School of Medicine, St. Louis, MO, USA; Department of Pediatric Dentistry, Center for Advanced Dental Education, Saint Louis University, St. Louis, MO, USA.

Publikováno v: Oral surgery, oral medicine, oral pathology and oral radiology [Oral Surg Oral Med Oral Pathol Oral Radiol] 2022 Oct; Vol. 134 (4), pp. 420-424. Date of Electronic Publication: 2022 Feb 12.