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pro vyhledávání: '"Robbie S. Lindsay"'
Autor:
Robbie S. Lindsay, Caroline Mckenzie Leckie, Parvez Murad, John J. Mullins, Christopher R. W. Edwards, Yuri Kotelevtsev, Jonathan R. Seckl, Roger W. Brown, Lawrence P. Brett, Karen E. Chapman, Joyce L.W. Yau, Val Lyons
Publikováno v:
Biochemical Journal. 313:1007-1017
By inactivating potent glucocorticoid hormones (cortisol and corticosterone), 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta-HSD2) plays an important role in the placenta by controlling fetal exposure to maternal glucocorticoids, and in aldoste
Publikováno v:
Steroids. 61(4)
Recent studies have demonstrated that the interconversion of active and inactive glucocorticoids plays a key role in determining the specificity of the mineralocorticoid receptor and controlling local tissue glucocorticoid receptor activation. Two di
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 55(5-6)
Excessive foetal exposure to glucocorticoids retards growth and "programmes" adult hypertension in rats. Placental 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD), which catalyses the conversion of corticosterone and cortisol to inert 11 keto-prod