Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Robbie L, McLeod"'
Autor:
Joey L. Methot, Hua Zhou, Sam D. Kattar, Meredeth A. McGowan, Kevin Wilson, Yudith Garcia, Yongi Deng, Michael Altman, Xavier Fradera, Charles Lesburg, Thierry Fischmann, Chaomin Li, Steve Alves, Sanjiv Shah, Rafael Fernandez, Peter Goldenblatt, Armetta Hill, Lynsey Shaffer, Dapeng Chen, Vince Tong, Robbie L. McLeod, Hongshi Yu, Alan Bass, Ray Kemper, Nicholas T. Gatto, Lisa LaFranco-Scheuch, Benjamin Wesley Trotter, Timothy Guzi, Jason D. Katz
Publikováno v:
Journal of Medicinal Chemistry. 62:4370-4382
PI3Kδ catalytic activity is required for immune cell activation, and has been implicated in inflammatory diseases as well as hematological malignancies in which the AKT pathway is overactive. A purine PI3Kδ inhibitor bearing a benzimidazolone-piper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22455e06a228a36e7b0e36ea97794591
https://doi.org/10.1021/acs.jmedchem.8b01818
https://doi.org/10.1021/acs.jmedchem.8b01818
Autor:
Jason D. Katz, François G. Gervais, Lauren Dorosh, Milenko Cicmil, Khamir Mehta, Joey L. Methot, Janice D Woodhouse, Hongshi Yu, Hani Houshyar, Prasanthi Geda, Gretchen A. Baltus, Malgorzata A Gil, Antonio Cabal, Sanjiv J. Shah, Robbie L. McLeod, Dapeng Chen, Alan S. Bass, Stephen E. Alves, Michael Caniga
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 369:223-233
We leveraged a clinical pharmacokinetic (PK)/pharmacodynamics (PD)/efficacy relationship established with an oral phosphatidylinositol 3-kinase (PI3K)δ inhibitor (Idelalisib) in a nasal allergen challenge study to determine whether a comparable PK/P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ae30672ed16800c8692f183b1d4851d
https://doi.org/10.1124/jpet.118.252551
https://doi.org/10.1124/jpet.118.252551
Autor:
Benjamin Wesley Trotter, Xavier Fradera, Stephen E. Alves, Meredeth A. McGowan, Peter Goldenblatt, Jason D. Katz, Yudith Garcia, Lynsey Shaffer, Michael D. Altman, Matthew Christopher, Kathryn Lipford, Charles A. Lesburg, Hyun-Hee Lee, Chaomin Li, Craig P. Chappell, Vincent Tong, Elaine M. Pinheiro, Armetta D. Hill, Ruban Mangado, Renu Jain, Robbie L. McLeod, Sanjiv J. Shah, Hongshi Yu, Abdelghani Achab, Dapeng Chen, Joey L. Methot, Sybill M G Williams, Hua Zhou, Neville J. Anthony
Publikováno v:
Journal of medicinal chemistry. 64(8)
The approvals of idelalisib and duvelisib have validated PI3Kδ inhibitors for the treatment for hematological malignancies driven by the PI3K/AKT pathway. Our program led to the identification of structurally distinct heterocycloalkyl purine inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a62dfaa61d20ec22ebc7d156d70d73
https://pubmed.ncbi.nlm.nih.gov/33797901
https://pubmed.ncbi.nlm.nih.gov/33797901
Pharmacological inhibition of hematopoietic progenitor kinase 1 positively regulates T-cell function
Autor:
Steven Wells, Jason Laskey, Robbie L. McLeod, Brian M. Lacey, Joey L. Methot, Alexander Pasternak, Yun Wang, Mark Bittinger, Kelvin Xi Zhang, Sheila Ranganath, Haiyan Xu, Zangwei Xu, Peter Georgiev
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243145 (2020)
PLoS ONE
PLoS ONE
Hematopoietic progenitor kinase 1 (HPK1), a hematopoietic cell-specific Ste20-related serine/threonine kinase, is a negative regulator of signal transduction in immune cells, including T cells, B cells, and dendritic cells (DCs). In mice, HPK1 defici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3234babe86d28c0ae7e4532e260f0c1d
https://doaj.org/article/122f7b4dd63e4038920f174d5a32c1d4
https://doaj.org/article/122f7b4dd63e4038920f174d5a32c1d4
Autor:
Liming Liu, Jason Laskey, Raymond J. Moniz, Toya Nath Baral, Joann A. O'Connor, Archie Tse, Andrey Loboda, Robbie L. McLeod, Mike Lee, Minilik Angagaw, Jin-Hwan Han, SuChun Hsieh, Juha Punnonen, Sarah Javaid, Svetlana Sadekova, Hassan Issafras
Publikováno v:
Oncotarget
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) has been reported to mediate both tumorigenic and anti-tumor effects in vivo. Blockade of the CEACAM1 signaling pathway has recently been implicated as a novel mechanism for cancer i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0337f2187eca0ab43575ce74ff7b9e67
https://doi.org/10.18632/oncotarget.26108
https://doi.org/10.18632/oncotarget.26108
Autor:
Michael Salmon, Malgorzata A Gil, Khamir Mehta, Robbie L. McLeod, Luciano Goncalves, Michael Caniga, Marissa K Callahan, Janice D Woodhouse, Joseph Eckman, John R. Naber, Fraser McIntosh, Sandra A.G. Visser, David S. Ross, Susan Hill, Milenko Cicmil, Mark C Freke, Neil Johnson, Antonio Cabal
Publikováno v:
Journal of Aerosol Medicine and Pulmonary Drug Delivery. 29:362-377
Understanding the relationship between dose, lung exposure, and drug efficacy continues to be a challenging aspect of inhaled drug development. An experimental inhalation platform was developed using mometasone furoate to link rodent lung exposure to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a5a222e08d4cec24e48b45e1807118
https://doi.org/10.1089/jamp.2015.1253
https://doi.org/10.1089/jamp.2015.1253
Autor:
Robbie L, McLeod, Malgorzata A, Gil, Dapeng, Chen, Antonio, Cabal, Jason, Katz, Joey, Methot, Janice D, Woodhouse, Lauren, Dorosh, Prasanthi, Geda, Khamir, Mehta, Milenko, Cicmil, Gretchen A, Baltus, Alan, Bass, Hani, Houshyar, Michael, Caniga, Hongshi, Yu, Francois, Gervais, Stephen, Alves, Sanjiv, Shah
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 369(2)
We leveraged a clinical pharmacokinetic (PK)/pharmacodynamics (PD)/efficacy relationship established with an oral phosphatidylinositol 3-kinase (PI3K)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a514c7e08b5e85828f6fd96b70fba955
https://pubmed.ncbi.nlm.nih.gov/30804001
https://pubmed.ncbi.nlm.nih.gov/30804001
Autor:
Milenko Cicmil, Christopher W. Boyce, Garfield G. Mingo, Hong Mei, Gissela Lieber, Yongxin Yu, Yanlin Jia, Robbie L. McLeod, Michael C. Koss, John C. Hunter, John A. Hey, Jairam Palamanda
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 349:75-84
Nasal congestion is one of the most troublesome symptoms of many upper airways diseases. We characterized the effect of selective α2c-adrenergic agonists in animal models of nasal congestion. In porcine mucosa tissue, compound A and compound B contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd171596e15b5ee0bcf50a1dbd403914
https://doi.org/10.1124/jpet.113.210666
https://doi.org/10.1124/jpet.113.210666
Autor:
Chaomin Li, Charles A. Lesburg, Jason D. Katz, Xavier Fradera, Robbie L. McLeod, Ruban Mangado, Elaine M. Pinheiro, Sybil M. G. Williams, Benjamin Wesley Trotter, Craig P. Chappell, Stephen E. Alves, Armetta D. Hill, Sanjiv J. Shah, Lynsey Shaffer, Michael D. Altman, Joey L. Methot, Hua Zhou, Renu Jain, Dapeng Chen, Hyun-Hee Lee, Meredith A. McGowan, Peter Goldenblatt
Publikováno v:
Cancer Research. 79:2254-2254
Inhibitors of PI3Kdelta are approved as monotherapy for the treatment of hematologic malignancies such as follicular B-cell non-Hodgkin lymphoma, chronic lymphocytic leukemia, and small lymphocytic lymphoma. Recent reports suggest that inhibition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01203c857b786686ef70cf3c512ad5f8
https://doi.org/10.1158/1538-7445.am2019-2254
https://doi.org/10.1158/1538-7445.am2019-2254
Autor:
Lily Y. Moy, Garfield G. Mingo, Xiomara Fernandez, Yvette Crawley, Janice D Woodhouse, Shanil Keshwani, Gissela Lieber, John C. Anthes, Robbie L. McLeod, Yanlin Jia, Yu-Lu Ma, Johanna Jimenez, Joel A. Klappenbach, Michael Caniga, Milenko Cicmil, Malgorzata A Gil, Nancy Kelly
Publikováno v:
European Journal of Pharmacology. 718:290-298
Accumulating evidence indicates protective actions of mineralocorticoid antagonists (MR antagonists) on cardiovascular pathology, which includes blunting vascular inflammation and myocardial fibrosis. We examined the anti-inflammatory and anti-fibrot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c54642b5083a2271bc8c195c09bb508
https://doi.org/10.1016/j.ejphar.2013.08.019
https://doi.org/10.1016/j.ejphar.2013.08.019