Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Robbert Q. Kim"'
Autor:
Bianca D. M. van Tol, Bjorn R. van Doodewaerd, Guinevere S. M. Lageveen-Kammeijer, Bas C. Jansen, Cami M. P. Talavera Ormeño, Paul J. M. Hekking, Aysegul Sapmaz, Robbert Q. Kim, Angeliki Moutsiopoulou, David Komander, Manfred Wuhrer, Gerbrand J. van der Heden van Noort, Huib Ovaa, Paul P. Geurink
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Most insights into deubiquitinase (DUB) substrate specificity originate from studies with isolated di-ubiquitins (diUb), but in cells diUbs with different linkage types coexist. Here, the authors develop a mass spectrometric DUB activity assay that c
Externí odkaz:
https://doaj.org/article/2c3b7930e79a4065a586ae1d307ad567
Autor:
Willemijn van der Wulp, Anna M. Gram, Boris Bleijlevens, Renate S. Hagedoorn, Can Araman, Robbert Q. Kim, Jan Wouter Drijfhout, Paul W. H. I. Parren, Richard G. Hibbert, Rob C. Hoeben, Sander I. van Kasteren, Janine Schuurman, Maaike E. Ressing, Mirjam H. M. Heemskerk
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Therapeutic antibody-epitope conjugates (AECs) are promising new modalities to deliver immunogenic epitopes and redirect virus-specific T-cell activity to cancer cells. Nevertheless, many aspects of these antibody conjugates require optimization to i
Externí odkaz:
https://doaj.org/article/458e15a064ab40b08049bc6f97a6578d
Autor:
Jenny Kaur Singh, Rebecca Smith, Magdalena B. Rother, Anton J. L. de Groot, Wouter W. Wiegant, Kees Vreeken, Ostiane D’Augustin, Robbert Q. Kim, Haibin Qian, Przemek M. Krawczyk, Román González-Prieto, Alfred C. O. Vertegaal, Meindert Lamers, Sébastien Huet, Haico van Attikum
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Classical non-homologous end-joining (cNHEJ) is the dominant pathway used by human cells to repair DNA double-strand breaks (DSBs) and maintain genome stability. Here the authors show that PARP1-driven chromatin expansion allows the recruitment of ZN
Externí odkaz:
https://doaj.org/article/81eb6422ad4941fe875820f223a85fd7
Publikováno v:
Pharmaceuticals, Vol 16, Iss 4, p 547 (2023)
In the past two decades, drug candidates with a covalent binding mode have gained the interest of medicinal chemists, as several covalent anticancer drugs have successfully reached the clinic. As a covalent binding mode changes the relevant parameter
Externí odkaz:
https://doaj.org/article/23183883f9664977ac0095037f4f0750
Autor:
Robbert Q. Kim, Paul P. Geurink, Monique P. C. Mulder, Alexander Fish, Reggy Ekkebus, Farid El Oualid, Willem J. van Dijk, Duco van Dalen, Huib Ovaa, Hugo van Ingen, Titia K. Sixma
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Deubiquitinating enzymes (DUBs) are critical regulators of cellular processes by removing ubiquitin from specific targets. Here global kinetic modelling reveals the mechanism by which the low intrinsic activity of USP7 is substantially enhanced on a
Externí odkaz:
https://doaj.org/article/822bd4cb8eb04f3199afc82488ed53d3
Autor:
Surendra Kumar, Kolli, Alvaro, Molina-Cruz, Tamasa, Araki, Fiona J A, Geurten, Jai, Ramesar, Severine, Chevalley-Maurel, Hans J, Kroeze, Sascha, Bezemer, Clarize, de Korne, Roxanne, Withers, Nadia, Raytselis, Angela F, El Hebieshy, Robbert Q, Kim, Matthew A, Child, Soichiro, Kakuta, Hajime, Hisaeda, Hirotaka, Kobayashi, Takeshi, Annoura, Paul J, Hensbergen, Blandine M, Franke-Fayard, Carolina, Barillas-Mury, Ferenc A, Scheeren, Chris J, Janse
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(35)
Glutaminyl cyclase (QC) modifies N-terminal glutamine or glutamic acid residues of target proteins into cyclic pyroglutamic acid (pGlu). Here, we report the biochemical and functional analysis of
Publikováno v:
Journal of Medicinal Chemistry, 65(19), 13288-13304. AMER CHEMICAL SOC
The multifunctional human Parkinson's disease protein 7 (PARK7/DJ1) is an attractive therapeutic target due to its link with early-onset Parkinson's disease, upregulation in various cancers, and contribution to chemoresistance. However, only a few co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89387668ac6eb1240fdbc4a0fb656db3
https://hdl.handle.net/1887/3514348
https://hdl.handle.net/1887/3514348
Autor:
Anton J.L. de Groot, Jenny Kaur Singh, Haibin Qian, Rebecca Smith, Román González-Prieto, Magdalena B. Rother, Sébastien Huet, Haico van Attikum, Przemek M. Krawczyk, Meindert Lamers, Ostiane D’Augustin, Kees Vreeken, Wouter W. Wiegant, Robbert Q. Kim, Alfred C. O. Vertegaal
Publikováno v:
Nature Communications
Nature Communications, 2021, 12 (1), pp.6560. ⟨10.1038/s41467-021-26691-0⟩
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.6560. ⟨10.1038/s41467-021-26691-0⟩
Nature Communications, 12(1). NATURE PORTFOLIO
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Nature communications, 12(1):6560. Nature Publishing Group
Nature Communications, 2021, 12 (1), pp.6560. ⟨10.1038/s41467-021-26691-0⟩
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.6560. ⟨10.1038/s41467-021-26691-0⟩
Nature Communications, 12(1). NATURE PORTFOLIO
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Nature communications, 12(1):6560. Nature Publishing Group
DNA double-strand breaks (DSBs) are among the most deleterious types of DNA damage as they can lead to mutations and chromosomal rearrangements, which underlie cancer development. Classical non-homologous end-joining (cNHEJ) is the dominant pathway f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d300eba28f4d2643c3344084226732c5
https://doi.org/10.1038/s41467-021-26691-0
https://doi.org/10.1038/s41467-021-26691-0
Autor:
Donghyuk Shin, Gerbrand J. van der Heden van Noort, Ivan Đikić, Hermann Schindelin, Ines Tomašković, Dmitri V. Filippov, Robbert Q. Kim, Alexis Gonzalez, Mohit Misra, Huib Ovaa
Publikováno v:
Chemistry – A European Journal
Chemistry (Weinheim an Der Bergstrasse, Germany)
Chemistry-A European Journal, 27(7), 2506-2512. WILEY-V C H VERLAG GMBH
Chemistry-a European Journal
Chemistry (Weinheim an Der Bergstrasse, Germany)
Chemistry-A European Journal, 27(7), 2506-2512. WILEY-V C H VERLAG GMBH
Chemistry-a European Journal
Legionnaires’ disease is caused by infection with the intracellularly replicating Gram‐negative bacterium Legionella pneumophila. This pathogen uses an unconventional way of ubiquitinating host proteins by generating a phosphoribosyl linkage betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4b10fc01019ddee5dd299e2911891e
https://hdl.handle.net/1887/3182944
https://hdl.handle.net/1887/3182944
Autor:
Huib Ovaa, Gerbrand J. van der Heden van Noort, Jeroen D. C. Codée, Jerre M. Madern, Robbert Q. Kim, Yong Zhang, Ivan Dikic, Mohit Misra, Dmitri V. Filippov
Publikováno v:
Chembiochem
ChemBioChem, 21(20), 2903-2907
ChemBioChem, 21(20), 2903-2907. WILEY-V C H VERLAG GMBH
ChemBioChem, 21(20), 2903-2907. Wiley
ChemBioChem
ChemBioChem, 21(20), 2903-2907
ChemBioChem, 21(20), 2903-2907. WILEY-V C H VERLAG GMBH
ChemBioChem, 21(20), 2903-2907. Wiley
ChemBioChem
Stable NAD+ analogues carrying single atom substitutions in either the furanose ring or the nicotinamide part have proven their value as inhibitors for NAD+‐consuming enzymes. To investigate the potential of such compounds to inhibit the adenosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f070d59296dfb43825af2166be3f22d
https://hdl.handle.net/1887/3182570
https://hdl.handle.net/1887/3182570