Myosin II Synergizes with F-Actin to Promote DNGR-1-Dependent Cross-Presentation of Dead Cell-Associated Antigens

Autor: Oliver Schulz, Pavel Hanč, Jan P. Böttcher, Robbert Hoogeboom, Sandra S. Diebold, Pavel Tolar, Caetano Reis e Sousa

Publikováno v: Cell Reports, Vol 24, Iss 2, Pp 419-428 (2018)

Summary: Conventional type 1 DCs (cDC1s) excel at cross-presentation of dead cell-associated antigens partly because they express DNGR-1, a receptor that recognizes exposed actin filaments on dead cells. In vitro polymerized F-actin can be used as a

Externí odkaz: https://doaj.org/article/6ebd3271c52348109b8ffe7d12c34387

Identification of a Novel Proliferating Cell Fraction in Chronic Lymphocytic Leukaemia with High Expression of IgM and Chemokine Receptors

Autor: Daniel Friedman, Antony Long, Piers EM Patten, Robbert Hoogeboom

Publikováno v: Blood. 138:3711-3711

Chronic lymphocytic leukaemia (CLL) is characterised by the accumulation of malignant CD5+ B cells in the peripheral blood (PB), secondary lymphoid tissues and bone marrow. Currently considered an incurable disease, B cell receptor (BCR) signalling p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2dca8eb2ece7c531a29f0254a4497c6c
https://doi.org/10.1182/blood-2021-153415

B-Lymphoblastic Lymphomas Evolving from Follicular Lymphomas Co-Express Surrogate Light Chains and Mutated Gamma Heavy Chains

Autor: Bart J. Biemond, Philippus Kluin, Thera A. M. Wormhoudt, Andre B. Mulder, Monique E.C.M. Oud, Linda M. Slot, Robbert Hoogeboom, Aldo Jongejan, Laura A. Smit, Richard J. Bende, Antoine H. C. van Kampen, Carel J. M. van Noesel, Esther J. M. Schilder-Tol, Jeroen E. J. Guikema

Publikováno v: American journal of pathology, 186(12), 3273-3284. Elsevier Inc.
Slot, L M, Hoogeboom, R, Smit, L A, Wormhoudt, T A M, Biemond, B J, Oud, M E C M, Schilder-Tol, E J M, Mulder, A B, Jongejan, A, van Kampen, A H C, Kluin, P M, Guikema, J E J, Bende, R J & van Noesel, C J M 2016, ' B-Lymphoblastic Lymphomas Evolving from Follicular Lymphomas Co-Express Surrogate Light Chains and Mutated Gamma Heavy Chains ', American Journal of Pathology, vol. 186, no. 12, pp. 3273-3284 . https://doi.org/10.1016/j.ajpath.2016.07.027
The American Journal of Pathology, 186(12), 3273-3284. Elsevier
The American Journal of Pathology, 186(12), 3273-3284. ELSEVIER SCIENCE INC

Follicular lymphoma (FL) is an indolent B-cell non-Hodgkin lymphoma able to transform into germinal center-type diffuse large B-cell lymphoma. We describe four extraordinary cases of FL, which progressed to TdT+CD20- precursor B-lymphoblastic lymphom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f2f7a6d6b8aebb3e4378133a0c37fdb
https://pure.amc.nl/en/publications/blymphoblastic-lymphomas-evolving-from-follicular-lymphomas-coexpress-surrogate-light-chains-and-mutated-gamma-heavy-chains(e5531c88-fcd4-4088-8b88-7dd201297b63).html

Molecular Mechanisms of B Cell Antigen Gathering and Endocytosis

Autor: Robbert Hoogeboom, Pavel Tolar

Publikováno v: Current Topics in Microbiology and Immunology ISBN: 9783319261317

Generation of high-affinity, protective antibodies requires B cell receptor (BCR) signaling, as well as antigen internalization and presentation to helper T cells. B cell antigen internalization is initiated by antigen capture, either from solution o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1258f926bad8be432a184d4ac6f836d8
https://doi.org/10.1007/82_2015_476

Stereotypic rheumatoid factors that are frequently expressed in mucosa-associated lymphoid tissue-type lymphomas are rare in the labial salivary glands of patients with Sjögren's syndrome

Autor: Richard J, Bende, Linda M, Slot, Robbert, Hoogeboom, Thera A M, Wormhoudt, Akanbi O, Adeoye, Jeroen E J, Guikema, Carel J M, van Noesel

Publikováno v: Arthritisrheumatology (Hoboken, N.J.). 67(4)

Among autoimmune diseases, Sjögren's syndrome (SS) is most strongly associated with the development of malignant B cell lymphoma, in particular mucosa-associated lymphoid tissue (MALT)-type lymphoma. Previously, we have shown that in ∼40% of cases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d2dc7a49d5dbb032e9d495a467a0be11
https://pubmed.ncbi.nlm.nih.gov/25546553