Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Robb E. Wilentz"'
A Subset of Pancreatic Adenocarcinomas Demonstrates Coamplification of Topoisomerase IIα andHER2/neu
Autor:
Charles J. Yeo, Anirban Maitra, Raheela Ashfaq, Ayman Rahman, Robb E. Wilentz, Dana Wanzer, Donna E. Hansel
Publikováno v:
American Journal of Clinical Pathology. 123:28-35
We sought to identify the frequency of amplification of the topoisomerase IIα gene (TOP2A) in pancreatic cancer and determine the usefulness of TOP2A immunolabeling in screening for TOP2A and human epidermal growth factor receptor (HER)2/neu amplifi
Publikováno v:
International Journal of Gastrointestinal Cancer. 36:039-046
Maspin is both overexpressed in tumors and inflammation, implicating a possible role in bridging inflammation and neoplasia. Idiopathic inflammatory bowel disease (IBD) and IBD-associated dysplasias and carcinomas represent a prototype for studying t
Autor:
Joseph Geradts, John L. Cameron, Robb E. Wilentz, Helen Roberts, T. A. Sohn, Charles J. Yeo, Michael Goggins, Norihiro Sato, Christophe Rosty, Ralph H. Hruban
Publikováno v:
The American Journal of Surgical Pathology. 27:1495-1501
Patients with long-standing chronic pancreatitis are thought to be at increased risk of developing pancreatic ductal adenocarcinoma, but the mechanism for this increased risk is unknown. Since increasing evidence supports the notion that infiltrating
Autor:
Robb E. Wilentz, Anne E. Rader, N. Tjarda van Heek, Douglas O. Faigel, Anirban Maitra, Pedram Argani, Ralph H. Hruban, Denis M. McCarthy
Publikováno v:
Applied Immunohistochemistry & Molecular Morphology. :238-243
The interpretation of pancreas fine-needle aspiration (FNA) is extremely difficult given the cytologic overlap of neoplastic and reactive processes. Using serial analysis of gene expression, we have discovered 2 new markers of pancreatic adenocarcino
Autor:
Pedram Argani, Scott E. Kern, Kevin C. Conlon, Denis M. McCarthy, James R. Howe, Marianna Zahurak, Murray F. Brennan, Robb E. Wilentz, Charles J. Yeo, Ralph H. Hruban, John L. Cameron, David S. Klimstra
Publikováno v:
Modern Pathology. 16:272-278
The K-ras oncogene is activated in approximately 90% of pancreatic adenocarcinomas, and the DPC4 (MADH4/SMAD4) tumor suppressor gene is inactivated in approximately 55% of pancreatic adenocarcinomas. The contributions of these genetic alterations to
Autor:
John L. Cameron, Robb E. Wilentz, Ralph H. Hruban, John K. Boitnott, Taylor A. Sohn, Charles J. Yeo, Susan C. Abraham
Publikováno v:
The American Journal of Surgical Pathology. 27:110-120
Pancreaticoduodenectomy (Whipple resection) has evolved into a safe procedure in major high-volume medical centers for the treatment of pancreatic adenocarcinoma and refractory chronic pancreatitis. However, some Whipple resections performed for a cl
Autor:
Spyridon S Marinopoulos, Raheela Ashfaq, Michael A. Choti, Duyen T. Dang, Michael Torbenson, Anirban Maitra, Robb E. Wilentz, John K. Boitnott
Publikováno v:
Human Pathology. 33:871-876
In the normal liver, the transforming growth factor beta (TGF-β) signaling pathway plays an important role in inhibiting hepatocyte growth. This effect is mediated through Smad4 (or Dpc4), a tumor-suppressor gene that affects gene transcription and
Autor:
Robb E. Wilentz, Raheela Ashfaq, Michael Torbenson, John K. Boitnott, Michael A. Choti, Anirban Maitra, Jianzhou Wang
Publikováno v:
Modern Pathology. 15:826-830
Fibronectin plays an important role in cell-to-cell adhesion, cell migration, and cell signaling. In the liver, fibronectin expression has been studied primarily as a component of the extracellular matrix, but little information is available on the e
Autor:
Robb E. Wilentz, John L. Cameron, Ralph H. Hruban, Anirban Maitra, Carla R. Gunn, Charles J. Yeo, Taylor A. Sohn, Raheela Ashfaq, Ayman Rahman
Publikováno v:
American Journal of Clinical Pathology. 118:194-201
We immunohistochemically examined material from 36 pancreata (adenocarcinomas, 30 lesions; pancreatic intraepithelial neoplasia [PanIN], 65; normal pancreatic ducts, 30) for cyclooxygenase 2 (COX-2) with an automated platform. We analyzed 7 to 10 dis
Autor:
Taylor A. Sohn, Raheela Ashfaq, Robb E. Wilentz, Christine A. Iacobuzio-Donahue, Anirban Maitra, Ayman Rahman, Charles J. Yeo, Michael Goggins, John L. Cameron, Ralph H. Hruban, Scott E. Kern, Peter Argani, Renee Meyer
Publikováno v:
American Journal of Clinical Pathology. 118:52-59
We extended the results of a previous microarray analysis by immunohistochemical validation of differential protein expression in a series of 57 surgically resected infiltrating ductal pancreatic adenocarcinomas. Two representative genes were examine