Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Robb E Moses"'
Autor:
Chunli Wei, Yun Liu, Xiaoyan Liu, Jingliang Cheng, Jiewen Fu, Xiuli Xiao, Robb E. Moses, Xiaotao Li, Junjiang Fu
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Epithelial-mesenchymal transition (EMT) inducing transcription factor TWIST1 plays a vital role in cancer metastasis. How the tumor-suppressive E3 ligase, speckle-type POZ protein (SPOP), regulates TWIST1 in breast cancer remains unknown. In
Externí odkaz:
https://doaj.org/article/53bf77ef643b4f159d7a5e596ce1ce09
Autor:
Xiaohong Tan, Lu Tong, Lin Li, Jinjin Xu, Shaofang Xie, Lei Ji, Junjiang Fu, Qingwu Liu, Shihui Shen, Yun Liu, Yanhui Xiao, Feiran Gao, Robb E. Moses, Nabeel Bardeesy, Yanxiao Wang, Jishuai Zhang, Longying Tang, Lei Li, Kwok-kin Wong, Dianwen Song, Xiao Yang, Jian Liu, Xiaotao Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The underlying mechanisms by which Smad4 loss-of-function accelerates lung cancer metastasis is unclear. Here, the authors show PAK3 as a downstream effector of Smad4 promoting metastatic signalling and suggest Smad4-PAK3 regulation as a point of pot
Externí odkaz:
https://doaj.org/article/ee5586f99b7446ffa59de5f264ead74c
Autor:
Xiao Gao, Qingwei Wang, Ying Wang, Jiang Liu, Shuang Liu, Jian Liu, Xingli Zhou, Li Zhou, Hui Chen, Linian Pan, Jiwei Chen, Da Wang, Qing Zhang, Shihui Shen, Yu Xiao, Zhipeng Wu, Yiyun Cheng, Geng Chen, Syeda Kubra, Jun Qin, Lan Huang, Pei Zhang, Chuangui Wang, Robb E. Moses, David M. Lonard, Bert W. O’ Malley, Fuad Fares, Bianhong Zhang, Xiaotao Li, Lei Li, Jianru Xiao
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
How the REGγ-proteasome pathway is regulated during the cell cycle or genotoxic insults remains unclear. Here, the authors show that NIP30 acts as a molecular switch to regulate the REGγ-proteasome activity and may provide an approach to combat dru
Externí odkaz:
https://doaj.org/article/7b5a15238e124a499bbec73fb760c725
Autor:
Chunli Wei, Yun Liu, Xiaoyan Liu, Jingliang Cheng, Jiewen Fu, Xiuli Xiao, Robb E Moses, Xiaotao Li, Junjiang Fu
Publikováno v:
Cancer Research. 83:P2-16
Epithelial-mesenchymal transition (EMT) inducing transcription factor TWIST1 plays a vital role in cancer metastasis. How the tumor-suppressive E3 ligase, Speckle-type POZ protein (SPOP), regulates TWIST1 in breast cancer remains unknown. In this stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80a379918bd297cfcd96d0cca893d7ca
https://doi.org/10.1158/1538-7445.sabcs22-p2-16-03
https://doi.org/10.1158/1538-7445.sabcs22-p2-16-03
Publikováno v:
Translational Research. 246:33-48
Diabetic vascular endothelial impairment is one of the main causes of death in patients with diabetes lacking adequately defined mechanisms or effective treatments. REGγ, the 11S proteasome activator known to promote the degradation of cellular prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766c3cf0a12cc96b068c3e45717d68ba
https://doi.org/10.1016/j.trsl.2022.03.007
https://doi.org/10.1016/j.trsl.2022.03.007
Autor:
Jinjin Xu, Lei Zhou, Lei Ji, Fengyuan Chen, Karen Fortmann, Kun Zhang, Qingwu Liu, Ke Li, Weicang Wang, Hao Wang, Wei Xie, Qingwei Wang, Jiang Liu, Biao Zheng, Pei Zhang, Shixia Huang, Tieliu Shi, Biaohong Zhang, Yongyan Dang, Jiwu Chen, Bert W. O’Malley, Robb E. Moses, Ping Wang, Lei Li, Jianru Xiao, Alexander Hoffmann, Xiaotao Li
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
REGγ is a component of ubiquitin-independent 20S proteasome that targets many regulatory proteins for degradation. Here the authors show that REGγ is induced in DSS colitis and promotes degradation of IκBɛ, and that REGγ-deficient mice have less
Externí odkaz:
https://doaj.org/article/815ed3c7811843c397e9095adc1ff9cf
Autor:
Xiaotao Li, Yongyan Dang, Lei Li, Jianru Xiao, Junjiang Fu, Fengyuan Chen, Jianhua Yang, Robb E. Moses, Pei Zhang, Long Cui, Quan Huang, Wang Zhou, Chan Jiao, Geng Chen, Weicang Wang, Jie Dai, Lei Yuan, Tong Yu, Xiao Gao, Qingwei Wang
Supplementary Figure1-10, Table1-2 Figure S1. The relations of REGγ with Hippo-YAP signal pathway in colon cancer. A. The protein levels of Lats2 and p-Lats1 were unchanged in HCT116 and HT29 human colon cancer cells with REGγ knockdown. The ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a42709953f50ea786597df3644f046
https://doi.org/10.1158/1078-0432.22465626
https://doi.org/10.1158/1078-0432.22465626
Autor:
Xiaotao Li, Yongyan Dang, Lei Li, Jianru Xiao, Junjiang Fu, Fengyuan Chen, Jianhua Yang, Robb E. Moses, Pei Zhang, Long Cui, Quan Huang, Wang Zhou, Chan Jiao, Geng Chen, Weicang Wang, Jie Dai, Lei Yuan, Tong Yu, Xiao Gao, Qingwei Wang
Purpose: Colorectal cancer is one of the most commonly diagnosed cancers closely associated with inflammation and hyperactive growth. We previously demonstrated a regulatory circuit between the proteasome activator REGγ and NF-kappaB (NF-κB) during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a32f8befc6f210cc25f3f5a70dbe7c5
https://doi.org/10.1158/1078-0432.c.6525890.v1
https://doi.org/10.1158/1078-0432.c.6525890.v1
Autor:
Xiao Gao, Qingwei Wang, Ying Wang, Jiang Liu, Shuang Liu, Jian Liu, Xingli Zhou, Li Zhou, Hui Chen, Linian Pan, Jiwei Chen, Da Wang, Qing Zhang, Shihui Shen, Yu Xiao, Zhipeng Wu, Yiyun Cheng, Geng Chen, Syeda Kubra, Jun Qin, Lan Huang, Pei Zhang, Chuangui Wang, Robb E. Moses, David M. Lonard, Bert W. O’ Malley, Fuad Fares, Bianhong Zhang, Xiaotao Li, Lei Li, Jianru Xiao
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/a9b4ebd46ecc442db6f2ac93d22cbc3e
Autor:
Yaodong Zhang, Lei Li, Yuping Ren, Bo Yang, Xiangzhan Zhu, Ya Li, Xiaotao Li, Jianhui Li, Bing Wang, Robb E. Moses, Fangxia Guan, Tingmei Huang, Ying Zhang, Solomon Kibreab Mael, Zaijun Lin, Zimeng Wang, Bianhong Zhang, Minglei Yang, Zhenlong Li, Lili Zhang, Yaqi Kong
Publikováno v:
Science China Life Sciences. 65:1608-1623
Leucine-rich repeat containing G protein-coupled receptor 5 (Lgr5), a marker of intestinal stem cells (ISCs), is considered to play key roles in tissue homoeostasis and regeneration after acute radiation injury. However, the activation of Lgr5 by int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68f9ecec4acebb01f75db54cd3783619
https://doi.org/10.1007/s11427-021-2018-7
https://doi.org/10.1007/s11427-021-2018-7