Multi-omics after O-GlcNAc alteration identified cellular processes promoting aneuploidy after loss of O-GlcNAc transferase.

Autor: Boyd SS; Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, KS, USA., Robarts DR; Department of Pharmacology, Toxicology and Therapeutics, Kansas City, KS, USA., Nguyen K; Department of Biochemistry, University of Kansas Medical Center, Kansas City, KS, USA., Villar M; Department of Biochemistry, University of Kansas Medical Center, Kansas City, KS, USA., Alghusen IM; Department of Biochemistry, University of Kansas Medical Center, Kansas City, KS, USA., Kotulkar M; Department of Pharmacology, Toxicology and Therapeutics, Kansas City, KS, USA., Denson A; Department of Biochemistry, University of Kansas Medical Center, Kansas City, KS, USA., Fedosyuk H; Department of Biochemistry, University of Kansas Medical Center, Kansas City, KS, USA., Whelan SA; Department of Chemistry, Boston University, Boston, MA, USA; Precision Biomarker Laboratories, Cedars-Sinai Medical Center, Beverly Hills, CA, USA., Lee NCY; Department of Chemistry, Boston University, Boston, MA, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Hanover J; Laboratory of Cell Biochemistry and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Dias WB; Federal University of Rio De Janeiro, Rio De Janeiro, Brazil., Tan EP; Department of Biochemistry, University of Kansas Medical Center, Kansas City, KS, USA; Department of Chemistry, Neurodegeneration New Medicines Center, and the Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA., McGreal SR; Department of Pharmacology, Toxicology and Therapeutics, Kansas City, KS, USA; XenoTech, A BioIVT Company, Kansas City, KS, USA., Artigues A; Department of Biochemistry, University of Kansas Medical Center, Kansas City, KS, USA., Swerdlow RH; Department of Biochemistry, University of Kansas Medical Center, Kansas City, KS, USA; Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA; University of Kansas Alzheimer's Disease Research Center, KS, USA., Thompson JA; Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, KS, USA; University of Kansas Cancer Center, Kansas City, KS, USA., Apte U; Department of Pharmacology, Toxicology and Therapeutics, Kansas City, KS, USA., Slawson C; Department of Biochemistry, University of Kansas Medical Center, Kansas City, KS, USA; University of Kansas Alzheimer's Disease Research Center, KS, USA; University of Kansas Cancer Center, Kansas City, KS, USA. Electronic address: cslawson@kumc.edu.

Publikováno v: Molecular metabolism [Mol Metab] 2024 Oct 29; Vol. 90, pp. 102060. Date of Electronic Publication: 2024 Oct 29.

Regulation of hepatic xenosensor function by HNF4alpha.

Autor: Kotulkar M; Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, United States., Paine-Cabrera D; Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, United States., Robarts DR; Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, United States., Apte U; Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, United States.

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2024 Aug 01; Vol. 200 (2), pp. 346-356.

Leukocyte cell-derived chemotaxin 2 correlates with pediatric non-alcoholic fatty liver disease.

Autor: Paine-Cabrera D; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA., Harvey LK; Division of Gastroenterology, Hepatology, and Nutrition, Children's Mercy - Kansas City, Kansas City, Missouri, USA., Robarts DR; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA., Pritchard MT; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA.; University of Kansas Liver Center, Kansas City, Kansas, USA., Thyfault J; Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA.; Children's Center for Healthy Lifestyles and Nutrition, Kansas City, Missouri, USA., Weinman SA; University of Kansas Liver Center, Kansas City, Kansas, USA.; Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA., Apte U; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA.; University of Kansas Liver Center, Kansas City, Kansas, USA.; Children's Center for Healthy Lifestyles and Nutrition, Kansas City, Missouri, USA., Slowik V; Division of Gastroenterology, Hepatology, and Nutrition, Children's Mercy - Kansas City, Kansas City, Missouri, USA.; Children's Center for Healthy Lifestyles and Nutrition, Kansas City, Missouri, USA.

Publikováno v: Clinical and translational science [Clin Transl Sci] 2023 Dec; Vol. 16 (12), pp. 2719-2728. Date of Electronic Publication: 2023 Oct 27.

The essential role of O-GlcNAcylation in hepatic differentiation.

Autor: Robarts DR; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA., Kotulkar M; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA., Paine-Cabrera D; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA., Venneman KK; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA., Hanover JA; Laboratory of Cell Biochemistry and Molecular Biology, NIDDK, NIH, Bethesda, Maryland, USA., Zachara NE; Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Slawson C; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, USA., Apte U; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA.

Publikováno v: Hepatology communications [Hepatol Commun] 2023 Nov 06; Vol. 7 (11). Date of Electronic Publication: 2023 Nov 06 (Print Publication: 2023).

Hyaluronan synthesis inhibition normalizes ethanol-enhanced hepatic stellate cell activation.

Autor: Kotulkar M; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA., Robarts DR; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA., Lin-Rahardja K; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA., McQuillan T; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA., Surgnier J; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA., Tague SE; Kansas Intellectual and Developmental Disabilities Research Center, University of Kansas Medical Center, Kansas City, Kansas, USA., Czerwinski M; XenoTech BioIVT, Kansas City, Kansas, USA., Dennis KL; Department of Pathology, University of Kansas Medical Center, Kansas City, Kansas, USA., Pritchard MT; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA.; The Liver Center, University of Kansas Medical Center, Kansas City, Kansas, USA.

Publikováno v: Alcohol, clinical & experimental research [Alcohol Clin Exp Res (Hoboken)] 2023 Aug; Vol. 47 (8), pp. 1544-1559. Date of Electronic Publication: 2023 Jun 18.