Mild dyserythropoiesis and β-like globin gene expression imbalance due to the loss of histone chaperone ASF1B

Autor: Petros Papadopoulos, Athanassia Kafasi, Iris M. De Cuyper, Vilma Barroca, Daniel Lewandowski, Zahra Kadri, Martijn Veldthuis, Jeffrey Berghuis, Nynke Gillemans, Celina María Benavente Cuesta, Frank G. Grosveld, Rob van Zwieten, Sjaak Philipsen, Muriel Vernet, Laura Gutiérrez, George P. Patrinos

Publikováno v: Human Genomics, Vol 14, Iss 1, Pp 1-12 (2020)

Abstract The expression of the human β-like globin genes follows a well-orchestrated developmental pattern, undergoing two essential switches, the first one during the first weeks of gestation (ε to γ), and the second one during the perinatal peri

Externí odkaz: https://doaj.org/article/ebde74cd3e4042dc96bb58a33041796f

Pleiotropic Effects of Hydroxyurea on Red Blood Cell and Neutrophil Phenotype in Patients with Sickle Cell Disease; Data from the Notice Study

Autor: Aafke E. Gaartman, Lydian A. de Ligt, Anton T.J. Tool, Boukje M. Beuger, Martijn Veldthuis, Taco W. Kuijpers, Rob van Zwieten, Bart J. Biemond, Robin Van Bruggen, Erfan Nur

Publikováno v: Blood. 140:2551-2553

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7492d3334342a915f516f062b96ad424
https://doi.org/10.1182/blood-2022-169070

The Gardos effect drives erythrocyte senescence and leads to Lu/BCAM and CD44 adhesion molecule activation

Autor: Thomas R. L. Klei, Robin van Bruggen, Iris M Seignette, Taco W. Kuijpers, Peter C. Ligthart, Jill J Dalimot, Rob van Zwieten, Martijn Veldthuis, Paul Verkuijlen, Fatima Ait Ichou, Boukje M. Beuger

Publikováno v: Blood Adv
Blood advances, 4(24), 6218-6229. American Society of Hematology

Senescence of erythrocytes is characterized by a series of changes that precede their removal from the circulation, including loss of red cell hydration, membrane shedding, loss of deformability, phosphatidyl serine exposure, reduced membrane sialic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1812bee59409dede7631b718e51cf30
https://pubmed.ncbi.nlm.nih.gov/33351118

Rapid diagnosis of hereditary haemolytic anaemias using automated rheoscopy and supervised machine learning

Autor: Paola Bianchi, Johannes G. G. Dobbe, Geert J. Streekstra, Martijn Veldthuis, Elisa Fermo, Timothy J. Satchwell, Rob van Zwieten, Richard van Wijk, Ashley M. Toye, Pedro L. Moura, Minke A.E. Rab

Publikováno v: Moura, P L, Dobbe, J G G, Streekstra, G J, Rab, M A E, Veldthuis, M, Fermo, E, van Wijk, R, van Zwieten, R, Bianchi, P, Toye, A M & Satchwell, T 2020, ' Rapid diagnosis of hereditary haemolytic anaemias using automated rheoscopy and supervised machine learning ', British Journal of Haematology . https://doi.org/10.1111/bjh.16868
British Journal of Haematology
British journal of haematology, 190(4), e250-e255. Wiley-Blackwell

[No Abstract]

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d344171cde2dcc73acdf99b40b353a48
https://research-information.bris.ac.uk/en/publications/4533f96b-a5dd-434f-84a7-bf2eddb9d5f7

Residual pyruvate kinase activity in PKLR-deficient erythroid precursors of a patient suffering from severe haemolytic anaemia

Autor: Thomas R. L. Klei, Judy Geissler, Robin van Bruggen, Mehran Karimi, Sima Kheradmand Kia, Martijn Veldthuis, Rob van Zwieten, Javad Dehbozorgian, Boukje M. Beuger

Publikováno v: European journal of haematology, 98(6), 584-589. Wiley-Blackwell

Objective Here, we present a 7-year-old patient suffering from severe haemolytic anaemia. The most common cause of chronic hereditary non-spherocytic haemolytic anaemia is red blood cell pyruvate kinase (PK-R) deficiency. Because red blood cells rely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c45d62ae8c10864392ae7620e7e0217f
https://doi.org/10.1111/ejh.12874