Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Rob Towart"'
Autor:
Eva Wrobel, Ina Rothenberg, Christoph Krisp, Franziska Hundt, Benjamin Fraenzel, Karina Eckey, Joannes T. M. Linders, David J. Gallacher, Rob Towart, Lutz Pott, Michael Pusch, Tao Yang, Dan M. Roden, Harley T. Kurata, Eric Schulze-Bahr, Nathalie Strutz-Seebohm, Dirk Wolters, Guiscard Seebohm
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Specificity of inhibitors of voltage-gated ion channels is crucial for their use as therapeutics. Here, the authors show that adamantane derivatives interact with a specific binding site on fenestrations that only become available when accessory subu
Externí odkaz:
https://doaj.org/article/6f13dc5b883d4828afc6c8522bd13d5d
Autor:
Jeffrey H. Price, David J. Gallacher, Mark Mercola, Piyush Gehalot, Fabio Cerignoli, Rob Towart, Alex Savchenko, Ross Whittaker, Patrick M. McDonough, Randy Ingermanson, David J. Charlot
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 66:246-256
Current methods to measure physiological properties of cardiomyocytes and predict fatal arrhythmias that can cause sudden death, such as Torsade de Pointes, lack either the automation and throughput needed for early-stage drug discovery and/or have p
Autor:
Karina Eckey, Tao Yang, Christoph Krisp, Ina Rothenberg, Dan M. Roden, Nathalie Strutz-Seebohm, Michael Pusch, Eric Schulze-Bahr, Harley T. Kurata, Joannes T. M. Linders, Rob Towart, Dirk Wolters, Guiscard Seebohm, Eva Wrobel, Benjamin Fraenzel, Lutz Pott, Franziska Hundt, David J. Gallacher
Publikováno v:
Nature communications 7 (2016). doi:10.1038/ncomms12795
info:cnr-pdr/source/autori:Wrobel E, Rothenberg I, Krisp C, Hundt F, Fraenzel B, Eckey K, Linders JT, Gallacher DJ, Towart R, Pott L, Pusch M, Yang T, Roden DM, Kurata HT, Schulze-Bahr E, Strutz-Seebohm N, Wolters D, Seebohm G/titolo:KCNE1 induces fenestration in the Kv7.1%2FKCNE1 channel complex that allows for highly specific pharmacological targeting/doi:10.1038%2Fncomms12795/rivista:Nature communications/anno:2016/pagina_da:/pagina_a:/intervallo_pagine:/volume:7
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications
info:cnr-pdr/source/autori:Wrobel E, Rothenberg I, Krisp C, Hundt F, Fraenzel B, Eckey K, Linders JT, Gallacher DJ, Towart R, Pott L, Pusch M, Yang T, Roden DM, Kurata HT, Schulze-Bahr E, Strutz-Seebohm N, Wolters D, Seebohm G/titolo:KCNE1 induces fenestration in the Kv7.1%2FKCNE1 channel complex that allows for highly specific pharmacological targeting/doi:10.1038%2Fncomms12795/rivista:Nature communications/anno:2016/pagina_da:/pagina_a:/intervallo_pagine:/volume:7
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications
Most small-molecule inhibitors of voltage-gated ion channels display poor subtype specificity because they bind to highly conserved residues located in the channel's central cavity. Using a combined approach of scanning mutagenesis, electrophysiology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7b21cbf9257e48ed4bd20e6d4cb4ee
http://www.scopus.com/inward/record.url?eid=2-s2.0-84991508551&partnerID=q2rCbXpz
http://www.scopus.com/inward/record.url?eid=2-s2.0-84991508551&partnerID=q2rCbXpz
Autor:
Rob Towart, G McIntyre, Hua Rong Lu, Michael K. Pugsley, G Eichenbaum, JM Davenport, Jutta Rohrbacher, U Shukla, David J. Gallacher, V Hillsamer
Publikováno v:
British Journal of Pharmacology. 166:1694-1707
BACKGROUND AND PURPOSE JNJ-Q2, a novel broad-spectrum fluoroquinolone with anti-methicillin-resistant Staphylococcus aureus activity, was evaluated in a comprehensive set of non-clinical and clinical cardiovascular safety studies. The effect of JNJ-Q
Autor:
Thomas A. Jepps, Friederike Zunke, Alison J. Davis, Joannes Theodorus Maria Linders, Michael Schwake, Rob Towart, Iain A. Greenwood, Preet S. Chadha
Publikováno v:
British Journal of Pharmacology. 166:1377-1387
BACKGROUND AND PURPOSE The aim of this study was to characterize the functional impact of KCNQ1-encoded voltage-dependent potassium channels (Kv7.1) in the vasculature. EXPERIMENTAL APPROACH Mesenteric arteries, intrapulmonary arteries and thoracic a
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 64:1-6
This issue of the Journal of Pharmacological and Toxicological Methods (JPTM) is themed. It is the eighth in a series, arising from the Annual Safety Pharmacology Society (SPS) meeting. The SPS is now in its 10th year as an independent branch of biol
Publikováno v:
British Journal of Pharmacology. 161:1444-1454
BACKGROUND AND PURPOSE In cardiovascular pharmacology, electrical and mechanical events can be distinguished, and the phrase ‘electro-mechanical window’ (EMw) describes the temporal difference between these events. We studied whether changes in E
Autor:
Henk van der Linde, Rob Towart, An N. Hermans, Peter Walter Maria Roevens, Jutta Rohrbacher, David J. Gallacher, Ard Teisman, Martine Ercken, Miroslav Cik, Joannes Theodorus Maria Linders
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 60:1-10
The problem of drug-induced hERG channel blockade, which can lead to acquired long QT syndrome and potentially fatal arrhythmias, has exercised drug developers and regulatory authorities for over 10 years, and exacting guidelines have been put into p
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 60:24-27
Assessing drug-induced changes (particularly prolongation) in the QT interval has been the major preoccupation of safety pharmacology since its inception, under the assumption that QT widening represents a surrogate biomarker for torsades de pointes
Publikováno v:
British Journal of Pharmacology. 154:1474-1481
Background and purpose: Body core temperature (Tc) changes affect the QT interval, but correction for this has not been systematically investigated. It may be important to correct QT intervals for drug-induced changes in Tc.