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Autor:
George E. Duran, Dejan Juric, E. Brian Francisco, Daniela Witten, Rob Tibshrani, Branimir I. Sikic, Cindy Y. Wang
Publikováno v:
Cancer Research. 70:1526-1526
Taxanes are important drugs in the treatment of ovarian cancers, but their efficacy is limited by intrinsic and acquired drug resistance. Over-expression of the MDR1 gene and its product, P-glycoprotein, is a well-characterized resistance mechanism t