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Autor:
Xicheng Sun, Jennifer Bertino, Kim Stone, Rob Sabin, Joseph Guiles, Charles S. McHenry, Frank B. Dean, Louis S. Green, Urs A. Ochsner, Ian A. Critchley, H. Garry Dallmann, Nebojsa Janjic, Ming Tregay
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(3)
High throughput screening led to the discovery of a novel series of quinazolin-2-ylamino-quinazolin-4-ols as a new class of DNA polymerase III inhibitors. The inhibition of chromosomal DNA replication results in bacterial cell death. The synthesis, s