Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Rob S. Sellar"'
Autor:
Rob S. Sellar, Adam S. Sperling, Mikołaj Słabicki, Jessica A. Gasser, Marie E. McConkey, Katherine A. Donovan, Nada Mageed, Dylan N. Adams, Charles Zou, Peter G. Miller, Ravi K. Dutta, Steffen Boettcher, Amy E. Lin, Brittany Sandoval, Vanessa A. Quevedo Barrios, Veronica Kovalcik, Jonas Koeppel, Elizabeth K. Henderson, Emma C. Fink, Lu Yang, Anthony Chan, Sheela Pangeni Pokharel, Erik J. Bergstrom, Rajan Burt, Namrata D. Udeshi, Steven A. Carr, Eric S. Fischer, Chun-Wei Chen, Benjamin L. Ebert
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 16 (2022)
Targeted protein degradation is a rapidly advancing and expanding therapeutic approach. Drugs that degrade GSPT1 via the CRL4CRBN ubiquitin ligase are a new class of cancer therapy in active clinical development with evidence of activity against acut
Externí odkaz:
https://doaj.org/article/81fae13f3404407c97508eb3a6337c9d
Autor:
Benjamin L. Ebert, Steven A. Carr, Philip P. Chamberlain, Mark Rolfe, Jean-Michel Cayuela, Jean-Jacques Kiladjian, Stéphane De Botton, Véronique Saada, Christophe Marzac, Sophie Cotteret, Rob S. Sellar, Andrew A. Guirguis, Alexander Tepper, Kaushik Viswanathan, Marie McConkey, Thomas Clayton, Mary E. Matyskiela, Namrata D. Udeshi, Pierre M. Jean Beltran, Daniel E. Grinshpun, Jessica A. Gasser, Aline Renneville
Supplementary Methods, Figures, and Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08d3edb19dfbd0f47523bcd0445d5d1
https://doi.org/10.1158/2643-3230.22543713.v1
https://doi.org/10.1158/2643-3230.22543713.v1
Autor:
Benjamin L. Ebert, Steven A. Carr, Philip P. Chamberlain, Mark Rolfe, Jean-Michel Cayuela, Jean-Jacques Kiladjian, Stéphane De Botton, Véronique Saada, Christophe Marzac, Sophie Cotteret, Rob S. Sellar, Andrew A. Guirguis, Alexander Tepper, Kaushik Viswanathan, Marie McConkey, Thomas Clayton, Mary E. Matyskiela, Namrata D. Udeshi, Pierre M. Jean Beltran, Daniel E. Grinshpun, Jessica A. Gasser, Aline Renneville
Thalidomide analogues exert their therapeutic effects by binding to the CRL4CRBN E3 ubiquitin ligase, promoting ubiquitination and subsequent proteasomal degradation of specific protein substrates. Drug-induced degradation of IKZF1 and IKZF3 in B-cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57eb4d478e4fdb51c5ac5ce49a6e60d1
https://doi.org/10.1158/2643-3230.c.6550374.v1
https://doi.org/10.1158/2643-3230.c.6550374.v1
Autor:
Benjamin L. Ebert, Steven A. Carr, Philip P. Chamberlain, Mark Rolfe, Jean-Michel Cayuela, Jean-Jacques Kiladjian, Stéphane De Botton, Véronique Saada, Christophe Marzac, Sophie Cotteret, Rob S. Sellar, Andrew A. Guirguis, Alexander Tepper, Kaushik Viswanathan, Marie McConkey, Thomas Clayton, Mary E. Matyskiela, Namrata D. Udeshi, Pierre M. Jean Beltran, Daniel E. Grinshpun, Jessica A. Gasser, Aline Renneville
Supplementary Table 1. Proteomic data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680350b5736d467704658c272205ed4c
https://doi.org/10.1158/2643-3230.22543710.v1
https://doi.org/10.1158/2643-3230.22543710.v1
Autor:
Dennis Gillingham, Jessica A. Gasser, Rob S. Sellar, Eric S. Fischer, Max Jan, Todd R. Golub, Manisha Manojkumar, Nicolas H. Thomä, Quinlan L. Sievers, Claudia Scholl, Stefan Fröhling, Li R. Wang, Zuzanna Kozicka, Katherine A. Donovan, Emma C. Fink, Adam S. Sperling, Yen-Der Li, Steven M. Corsello, Mikolaj Slabicki, Richard D. Bunker, Georg Petzold, Benjamin L. Ebert, Dakota Suchyta, Jonas Koeppel
Publikováno v:
Nature
Molecular glue compounds induce protein–protein interactions that, in the context of a ubiquitin ligase, lead to protein degradation. Unlike traditional enzyme inhibitors, these molecular glue degraders act substoichiometrically to catalyse the rap
Autor:
Andrew A Guirguis, Benjamin L. Ebert, Sophie Cotteret, Marie McConkey, Rob S. Sellar, Mary E Matyskiela, Jessica A. Gasser, Christophe Marzac, Aline Renneville, Steven A. Carr, Alexander Tepper, Mark Rolfe, Namrata D. Udeshi, Kaushik Viswanathan, Stéphane de Botton, Thomas Clayton, Jean-Michel Cayuela, Philip P Chamberlain, Véronique Saada, Jean-Jacques Kiladjian, Pierre M. Jean Beltran, Daniel E Grinshpun
Publikováno v:
Blood Cancer Discov
Thalidomide analogues exert their therapeutic effects by binding to the CRL4CRBN E3 ubiquitin ligase, promoting ubiquitination and subsequent proteasomal degradation of specific protein substrates. Drug-induced degradation of IKZF1 and IKZF3 in B-cel
Autor:
Shah Kavi, Peter Libby, Tetsushi Nakao, Rob S. Sellar, Paul Carter, M. J. Gomes, Samuel D. Moscavitch, Yevgenia Tesmenitsky, Eugenia Shvartz, Marie McConkey, Victoria Ruvkun, Eva Kritikou, Shamsudheen K. Vellarikkal, Galina K. Sukhova, Waihay J. Wong, Benjamin L. Ebert, Andrew H. Lichtman, Amelie Vromman, Grasiele Sausen, Rajat M. Gupta
Publikováno v:
Circulation. 142
Introduction: Clonal hematopoiesis of indeterminate potential (CHIP) describes somatic mutations of bone marrow derived blood cells in the absence of overt hematological disease. CHIP correlates with aging and atherosclerotic cardiovascular diseases
Autor:
Galina K. Sukhova, Benjamin L. Ebert, Roberto Molinaro, Eduardo J. Folco, Rob S. Sellar, Grasiele Sausen, Peter Libby, Amelie Vromman
Publikováno v:
Circulation. 142
Introduction: In the current era of intense LDL lowering, superficial erosion may be on the rise as a cause of ACS (25-30%). Experimental data on human atheromata support a role for neutrophils and the formation of neutrophil extracellular traps (NET
Autor:
Marie McConkey, Rob S. Sellar, Benjamin L. Ebert, John G. Doench, Siddhartha Jaiswal, Josephine Kahn, Karsten Krug, Shaunt Fereshetian, Dylan N. Adams, Shruti Bhatt, Peter Miller, Brenton G. Mar, Haoling Zhu, Christopher J. Gibson, Steven A. Carr, Alexander J. Silver, Anthony Letai, Philipp Mertins
Publikováno v:
Blood. 132:1095-1105
Truncating mutations in the terminal exon of protein phosphatase Mg2+/Mn2+ 1D (PPM1D) have been identified in clonal hematopoiesis and myeloid neoplasms, with a striking enrichment in patients previously exposed to chemotherapy. In this study, we dem
Autor:
Rob S. Sellar, Julie-Aurore Losman
Publikováno v:
Hematology/Oncology Clinics of North America. 31:565-576
Clonal myeloid disorders are characterized by genetic alterations that activate cytokine signaling pathways and stimulate cell proliferation. These activated signaling pathways have been extensively studied as potential therapeutic targets, and tyros