Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Rob Ruijtenbeek"'
Autor:
Chen-Yi Liao, Patrick Engelberts, Andreea Ioan-Facsinay, Janna Eleonora Klip, Thomas Schmidt, Rob Ruijtenbeek, Erik H. J. Danen
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract The mechanism of action of bispecific antibodies (bsAbs) directing T-cell immunity to solid tumors is incompletely understood. Here, we screened a series of CD3xHER2 bsAbs using extracellular matrix (ECM) embedded breast cancer tumoroid arra
Externí odkaz:
https://doaj.org/article/3dbee69a51ca4c49b03f87873fef6082
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Necroptosis is a type of caspase-independent programmed cell death that has been implicated in cancer development. Activation of the canonical necroptotic pathway is often characterized with successive signaling events as the phosphorylation of mixed
Externí odkaz:
https://doaj.org/article/20221ed498774fcfacb90a5572074786
Autor:
Tom van der Wel, Riet Hilhorst, Hans den Dulk, Tim van den Hooven, Nienke M. Prins, Joost A. P. M. Wijnakker, Bogdan I. Florea, Eelke B. Lenselink, Gerard J. P. van Westen, Rob Ruijtenbeek, Herman S. Overkleeft, Allard Kaptein, Tjeerd Barf, Mario van der Stelt
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Chemical tools to monitor drug-target engagement of endogenous enzymes are essential for preclinical target validation. Here, the authors present a chemical genetics strategy to study target engagement of endogenous kinases, achieving specific labeli
Externí odkaz:
https://doaj.org/article/749ac4b664044b4d9100599885c8e063
Autor:
Joachim G J V Aerts, Ron H J Mathijssen, Sjoerd H van der Burg, Reinhard Dummer, Reno Debets, Mandy van Brakel, Ellen Kapiteijn, Daan P Hurkmans, Els M E Verdegaal, Sabrina A Hogan, Rik de Wijn, Lies Hovestad, Dianne M A van den Heuvel, Rob Ruijtenbeek, Marij J P Welters, Edwin A Basak, Herbert M Pinedo, Cor H J Lamers, Harmen J G van de Werken, John P Groten, Mitchell P Levesque
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Many cancer patients do not obtain clinical benefit from immune checkpoint inhibition. Checkpoint blockade targets T cells, suggesting that tyrosine kinase activity profiling of baseline peripheral blood mononuclear cells may predict clini
Externí odkaz:
https://doaj.org/article/fdec7b4cc229438683584ce62dfcc0e3
Autor:
Jing Chen, Esther A. Zaal, Celia R. Berkers, Rob Ruijtenbeek, Johan Garssen, Frank A. Redegeld
Publikováno v:
Cells, Vol 10, Iss 9, p 2287 (2021)
Multiple myeloma (MM) is a hematological malignancy that exhibits aberrantly high levels of proteasome activity. While treatment with the proteasome inhibitor bortezomib substantially increases overall survival of MM patients, acquired drug resistanc
Externí odkaz:
https://doaj.org/article/b8deaf7f23b84e31a76366f9b0620074
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151085 (2016)
O-GlcNAcylation is a reversible and dynamic protein post-translational modification in mammalian cells. The O-GlcNAc cycle is catalyzed by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). O-GlcNAcylation plays important role in many vital cellular e
Externí odkaz:
https://doaj.org/article/310d44b2251e4d02a1725eec147b100e
Autor:
Arturo Sanz, Daniela Ungureanu, Tuija Pekkala, Rob Ruijtenbeek, Ivo P Touw, Riet Hilhorst, Olli Silvennoinen
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18522 (2011)
Janus kinase 2 (JAK2) initiates signaling from several cytokine receptors and is required for biological responses such as erythropoiesis. JAK2 activity is controlled by regulatory proteins such as Suppressor of Cytokine Signaling (SOCS) proteins and
Externí odkaz:
https://doaj.org/article/69ae644367c84bc2b99c88a21596b32e
Autor:
Simone Lemeer, Chris Jopling, Faris Naji, Rob Ruijtenbeek, Monique Slijper, Albert J R Heck, Jeroen den Hertog
Publikováno v:
PLoS ONE, Vol 2, Iss 7, p e581 (2007)
BACKGROUND: Protein-tyrosine kinases (PTKs) regulate virtually all biological processes. PTKs phosphorylate substrates in a sequence-specific manner and relatively short peptide sequences determine selectivity. Here, we developed new technology to de
Externí odkaz:
https://doaj.org/article/225e56524339473c9213b28700334acb
Autor:
Eveline S.J.M. de Bont, Maikel P. Peppelenbosch, Willem A. Kamps, Rik de Wijn, Piet J. Boender, Rob Ruijtenbeek, Eelco W. Hoving, Frank J.G. Scherpen, Arja ter Elst, Wilfred F.A. den Dunnen, Sander H. Diks, Arend H. Sikkema
Progression in pediatric brain tumor growth is thought to be the net result of signaling through various protein kinase-mediated networks driving cell proliferation. Defining new targets for treatment of human malignancies, without a priori knowledge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f29f42f3789d1d1795aa6923db36a963
https://doi.org/10.1158/0008-5472.c.6499173.v1
https://doi.org/10.1158/0008-5472.c.6499173.v1
Autor:
Eveline S.J.M. de Bont, Maikel P. Peppelenbosch, Willem A. Kamps, Rik de Wijn, Piet J. Boender, Rob Ruijtenbeek, Eelco W. Hoving, Frank J.G. Scherpen, Arja ter Elst, Wilfred F.A. den Dunnen, Sander H. Diks, Arend H. Sikkema
Supplementary Table 3 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7179105b10aa07c5c0a300e2f4461130
https://doi.org/10.1158/0008-5472.22379208
https://doi.org/10.1158/0008-5472.22379208