Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Rob Ruijtenbeek"'
Autor:
Chen-Yi Liao, Patrick Engelberts, Andreea Ioan-Facsinay, Janna Eleonora Klip, Thomas Schmidt, Rob Ruijtenbeek, Erik H. J. Danen
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract The mechanism of action of bispecific antibodies (bsAbs) directing T-cell immunity to solid tumors is incompletely understood. Here, we screened a series of CD3xHER2 bsAbs using extracellular matrix (ECM) embedded breast cancer tumoroid arra
Externí odkaz:
https://doaj.org/article/3dbee69a51ca4c49b03f87873fef6082
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Necroptosis is a type of caspase-independent programmed cell death that has been implicated in cancer development. Activation of the canonical necroptotic pathway is often characterized with successive signaling events as the phosphorylation of mixed
Externí odkaz:
https://doaj.org/article/20221ed498774fcfacb90a5572074786
Autor:
Tom van der Wel, Riet Hilhorst, Hans den Dulk, Tim van den Hooven, Nienke M. Prins, Joost A. P. M. Wijnakker, Bogdan I. Florea, Eelke B. Lenselink, Gerard J. P. van Westen, Rob Ruijtenbeek, Herman S. Overkleeft, Allard Kaptein, Tjeerd Barf, Mario van der Stelt
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Chemical tools to monitor drug-target engagement of endogenous enzymes are essential for preclinical target validation. Here, the authors present a chemical genetics strategy to study target engagement of endogenous kinases, achieving specific labeli
Externí odkaz:
https://doaj.org/article/749ac4b664044b4d9100599885c8e063
Autor:
Joachim G J V Aerts, Ron H J Mathijssen, Sjoerd H van der Burg, Reinhard Dummer, Reno Debets, Mandy van Brakel, Ellen Kapiteijn, Daan P Hurkmans, Els M E Verdegaal, Sabrina A Hogan, Rik de Wijn, Lies Hovestad, Dianne M A van den Heuvel, Rob Ruijtenbeek, Marij J P Welters, Edwin A Basak, Herbert M Pinedo, Cor H J Lamers, Harmen J G van de Werken, John P Groten, Mitchell P Levesque
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Many cancer patients do not obtain clinical benefit from immune checkpoint inhibition. Checkpoint blockade targets T cells, suggesting that tyrosine kinase activity profiling of baseline peripheral blood mononuclear cells may predict clini
Externí odkaz:
https://doaj.org/article/fdec7b4cc229438683584ce62dfcc0e3
Autor:
Jing Chen, Esther A. Zaal, Celia R. Berkers, Rob Ruijtenbeek, Johan Garssen, Frank A. Redegeld
Publikováno v:
Cells, Vol 10, Iss 9, p 2287 (2021)
Multiple myeloma (MM) is a hematological malignancy that exhibits aberrantly high levels of proteasome activity. While treatment with the proteasome inhibitor bortezomib substantially increases overall survival of MM patients, acquired drug resistanc
Externí odkaz:
https://doaj.org/article/b8deaf7f23b84e31a76366f9b0620074
Autor:
Eveline S.J.M. de Bont, Maikel P. Peppelenbosch, Willem A. Kamps, Rik de Wijn, Piet J. Boender, Rob Ruijtenbeek, Eelco W. Hoving, Frank J.G. Scherpen, Arja ter Elst, Wilfred F.A. den Dunnen, Sander H. Diks, Arend H. Sikkema
Progression in pediatric brain tumor growth is thought to be the net result of signaling through various protein kinase-mediated networks driving cell proliferation. Defining new targets for treatment of human malignancies, without a priori knowledge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f29f42f3789d1d1795aa6923db36a963
https://doi.org/10.1158/0008-5472.c.6499173.v1
https://doi.org/10.1158/0008-5472.c.6499173.v1
Autor:
Eveline S.J.M. de Bont, Maikel P. Peppelenbosch, Willem A. Kamps, Rik de Wijn, Piet J. Boender, Rob Ruijtenbeek, Eelco W. Hoving, Frank J.G. Scherpen, Arja ter Elst, Wilfred F.A. den Dunnen, Sander H. Diks, Arend H. Sikkema
Supplementary Table 3 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7179105b10aa07c5c0a300e2f4461130
https://doi.org/10.1158/0008-5472.22379208
https://doi.org/10.1158/0008-5472.22379208
Autor:
Eveline S.J.M. de Bont, Maikel P. Peppelenbosch, Willem A. Kamps, Rik de Wijn, Piet J. Boender, Rob Ruijtenbeek, Eelco W. Hoving, Frank J.G. Scherpen, Arja ter Elst, Wilfred F.A. den Dunnen, Sander H. Diks, Arend H. Sikkema
Supplementary Figure 3 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff962a59ad7c870cf3bee0c54752aee
https://doi.org/10.1158/0008-5472.22379220.v1
https://doi.org/10.1158/0008-5472.22379220.v1
Autor:
Eveline S.J.M. de Bont, Maikel P. Peppelenbosch, Willem A. Kamps, Rik de Wijn, Piet J. Boender, Rob Ruijtenbeek, Eelco W. Hoving, Frank J.G. Scherpen, Arja ter Elst, Wilfred F.A. den Dunnen, Sander H. Diks, Arend H. Sikkema
Supplementary Figure 2 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219430cf2ab4aac459e615067654fdb9
https://doi.org/10.1158/0008-5472.22379223
https://doi.org/10.1158/0008-5472.22379223
Autor:
Eveline S.J.M. de Bont, Maikel P. Peppelenbosch, Willem A. Kamps, Rik de Wijn, Piet J. Boender, Rob Ruijtenbeek, Eelco W. Hoving, Frank J.G. Scherpen, Arja ter Elst, Wilfred F.A. den Dunnen, Sander H. Diks, Arend H. Sikkema
Supplementary Table 4 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::637b9cbd1263005fd5d09f7f65cb5b1e
https://doi.org/10.1158/0008-5472.22379205.v1
https://doi.org/10.1158/0008-5472.22379205.v1