Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Rob P, van de Woestijne"'
Autor:
Josephus H. M. Lange, Remco Henzen, Natasja de Bruin, Jelle de Vries, Wouter I. Iwema Bakker, Wouter de Looff, Arnold P. den Hartog, Stefan Verhoog, Rob P. van de Woestijne, Chris G. Kruse, Arnold van Loevezijn, Jennifer Venhorst, Martina A.W. van der Neut
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1605-1611
The discovery of non-basic N'-(arylsulfonyl)pyrazoline-1-carboxamidines as 5-HT6 antagonists with unique structural features was recently disclosed. Here we describe how this structural class was further developed by addressing an unexplored interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf6abbf2099e90ec1e67445cecda377
https://doi.org/10.1016/j.bmcl.2016.02.001
https://doi.org/10.1016/j.bmcl.2016.02.001
Autor:
Cor G de Korte, Stefan Verhoog, Martina A.W. van der Neut, Wouter I. Iwema Bakker, Alice J.M. Borst, Jennifer Venhorst, Chris G. Kruse, Natasja de Bruin, Rob P. van de Woestijne, Hiskias G. Keizer, Arnold van Loevezijn, Wouter de Looff, Jan-Willem van Wees, Maria J.P. van Dongen, Martijn van Hoeve
Publikováno v:
Journal of Medicinal Chemistry. 54:7030-7054
The 5-HT(6) receptor (5-HT(6)R) has been in the spotlight for several years regarding CNS-related diseases. We set out to discover novel, neutral 5-HT(6)R antagonists to improve off-target selectivity compared to basic amine-containing scaffolds domi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01b80e49fd141f75bc4e9afb4ff68b46
https://doi.org/10.1021/jm200466r
https://doi.org/10.1021/jm200466r
Autor:
Arnold, van Loevezijn, Jennifer, Venhorst, Wouter I, Iwema Bakker, Cor G, de Korte, Wouter, de Looff, Stefan, Verhoog, Jan-Willem, van Wees, Martijn, van Hoeve, Rob P, van de Woestijne, Martina A W, van der Neut, Alice J M, Borst, Maria J P, van Dongen, Natasja M W J, de Bruin, Hiskias G, Keizer, Chris G, Kruse
Publikováno v:
Journal of medicinal chemistry. 54(20)
The 5-HT(6) receptor (5-HT(6)R) has been in the spotlight for several years regarding CNS-related diseases. We set out to discover novel, neutral 5-HT(6)R antagonists to improve off-target selectivity compared to basic amine-containing scaffolds domi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::75ef008ee0bc37511a8ca06420a5a337
https://pubmed.ncbi.nlm.nih.gov/21866910
https://pubmed.ncbi.nlm.nih.gov/21866910