Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Rob N. de Jong"'
Autor:
Simone C. Oostindie, Hilma J. van der Horst, Margaret A. Lindorfer, Erika M. Cook, Jillian C. Tupitza, Clive S. Zent, Richard Burack, Karl R. VanDerMeid, Kristin Strumane, Martine E. D. Chamuleau, Tuna Mutis, Rob N. de Jong, Janine Schuurman, Esther C. W. Breij, Frank J. Beurskens, Paul W. H. I. Parren, Ronald P. Taylor
Publikováno v:
Haematologica, Vol 104, Iss 9 (2019)
CD20 monoclonal antibody therapies have significantly improved the outlook for patients with B-cell malignancies. However, many patients acquire resistance, demonstrating the need for new and improved drugs. We previously demonstrated that the natura
Externí odkaz:
https://doaj.org/article/8951ab20ead14f0a871191432d4962ce
Autor:
Simone C. Oostindie, Derek A. Rinaldi, Gijs G. Zom, Michael J. Wester, Desiree Paulet, Kusai Al-Tamimi, Els van der Meijden, Jennifer R. Scheick, Tessa Wilpshaar, Bart de Jong, Marloes Hoff-van den Broek, Rachel M. Grattan, Janita J. Oosterhoff, Julie Vignau, Sandra Verploegen, Peter Boross, Frank J. Beurskens, Diane S. Lidke, Janine Schuurman, Rob N. de Jong
Publikováno v:
Nature Biotechnology. 40:1509-1519
The use of therapeutic monoclonal antibodies is constrained because single antigen targets often do not provide sufficient selectivity to distinguish diseased from healthy tissues. We present HexElect®, an approach to enhance the functional selectiv
Autor:
Esther C.W. Breij, Rob N. de Jong, Paul W.H.I. Parren, Janine Schuurman, Ulf Forssmann, Andreas Lingnau, Richard G. Hibbert, Naomi Hoevenaars, Bart de Jong, Thessa Kroes, Boris S. Vuillermoz, Claudine Vermot-Desroches, Antonio Ortiz Buijsse, Frank J. Beurskens, Kristin Strumane, Marije B. Overdijk
Supplemental Tables Supplemental Figures Supplemental Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc0742629adc9c9f5ee0bce476596b4
https://doi.org/10.1158/1535-7163.22520991.v1
https://doi.org/10.1158/1535-7163.22520991.v1
Autor:
Esther C.W. Breij, Rob N. de Jong, Paul W.H.I. Parren, Janine Schuurman, Ulf Forssmann, Andreas Lingnau, Richard G. Hibbert, Naomi Hoevenaars, Bart de Jong, Thessa Kroes, Boris S. Vuillermoz, Claudine Vermot-Desroches, Antonio Ortiz Buijsse, Frank J. Beurskens, Kristin Strumane, Marije B. Overdijk
Higher-order death receptor 5 (DR5) clustering can induce tumor cell death; however, therapeutic compounds targeting DR5 have achieved limited clinical efficacy. We describe HexaBody-DR5/DR5, an equimolar mixture of two DR5-specific IgG1 antibodies w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f853ed6f8830a1d4904eeb661710e2
https://doi.org/10.1158/1535-7163.c.6542862.v1
https://doi.org/10.1158/1535-7163.c.6542862.v1
Autor:
Guanbo Wang, Xinyang Shao, Deniz Ugurlar, Albert J. R. Heck, Lingxiao Chaihu, Rongrong Dai, Rob N. de Jong, Meng Tian, Piet Gros
Publikováno v:
Analytical Chemistry. 92:15799-15805
The quaternary structure is an important feature regulating protein function. Native mass spectrometry contributes to untangling quaternary structures by preserving the integrity of protein complexes in the gas phase. Tandem mass spectrometry by coll
Autor:
Rob N de Jong, Frank J Beurskens, Sandra Verploegen, Kristin Strumane, Muriel D van Kampen, Marleen Voorhorst, Wendy Horstman, Patrick J Engelberts, Simone C Oostindie, Guanbo Wang, Albert J R Heck, Janine Schuurman, Paul W H I Parren
Publikováno v:
PLoS Biology, Vol 14, Iss 1, p e1002344 (2016)
IgG antibodies can organize into ordered hexamers on cell surfaces after binding their antigen. These hexamers bind the first component of complement C1 inducing complement-dependent target cell killing. Here, we translated this natural concept into
Externí odkaz:
https://doaj.org/article/bfabba60d9884594bbcd39074b399b29
Autor:
Johannes Preiner, Jürgen Strasser, Paul W. H. I. Parren, Peter Hinterdorfer, Janine Schuurman, Frank J. Beurskens, Rob N. de Jong
Publikováno v:
ACS Nano, 14(3), 2739-2750. AMER CHEMICAL SOC
Activation of membrane receptors through clustering is a common mechanism found in various biological systems. Spatial proximity of receptors may be transduced across the membrane to initiate signaling pathways or alternatively be recognized by perip
Autor:
Simone C, Oostindie, Derek A, Rinaldi, Gijs G, Zom, Michael J, Wester, Desiree, Paulet, Kusai, Al-Tamimi, Els, van der Meijden, Jennifer R, Scheick, Tessa, Wilpshaar, Bart, de Jong, Marloes, Hoff-van den Broek, Rachel M, Grattan, Janita J, Oosterhoff, Julie, Vignau, Sandra, Verploegen, Peter, Boross, Frank J, Beurskens, Diane S, Lidke, Janine, Schuurman, Rob N, de Jong
Publikováno v:
Nature biotechnology. 40(10)
The use of therapeutic monoclonal antibodies is constrained because single antigen targets often do not provide sufficient selectivity to distinguish diseased from healthy tissues. We present HexElect
Autor:
Steven J. Orcutt, Aran F. Labrijn, Adam Zwolak, Mark L. Chiu, William M. Atkins, Theo Rispens, Dennis R. Goulet, Rob N. de Jong
Publikováno v:
The Journal of Biological Chemistry
Journal of biological chemistry, 293(2), 651-661. American Society for Biochemistry and Molecular Biology Inc.
Journal of biological chemistry, 293(2), 651-661. American Society for Biochemistry and Molecular Biology Inc.
Bispecific antibodies (bsAbs) combine the antigen specificities of two distinct Abs and demonstrate therapeutic promise based on novel mechanisms of action. Among the many platforms for creating bsAbs, controlled Fab-arm exchange (cFAE) has proven us
Autor:
Margaret A. Lindorfer, Martine E.D. Chamuleau, Richard Burack, Paul W. H. I. Parren, Clive S. Zent, Ronald P. Taylor, Karl R. VanDerMeid, Tuna Mutis, Rob N. de Jong, Jillian C. Tupitza, Hilma J. van der Horst, Janine Schuurman, Erika M. Cook, Kristin Strumane, Frank J. Beurskens, Esther C.W. Breij, Simone C. Oostindie
Publikováno v:
Haematologica
Haematologica, 104(9), 1841-1852. Ferrata Storti Foundation
Haematologica, 104(9), 1841-1852. FERRATA STORTI FOUNDATION
Oostindie, S C, Van Der Horst, H J, Lindorfer, M A, Cook, E M, Tupitza, J C, Zent, C S, Burack, R, VanDerMeid, K R, Strumane, K, Chamuleau, M E D, Mutis, T, De Jong, R N, Schuurman, J, Breij, E C W, Beurskens, F J, Parren, P W H I & Taylor, R P 2019, ' CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering ', Haematologica, vol. 104, no. 9, pp. 1841-1852 . https://doi.org/10.3324/haematol.2018.207266
Haematologica, 104(9), 1841-1852. Ferrata Storti Foundation
Haematologica, 104(9), 1841-1852. FERRATA STORTI FOUNDATION
Oostindie, S C, Van Der Horst, H J, Lindorfer, M A, Cook, E M, Tupitza, J C, Zent, C S, Burack, R, VanDerMeid, K R, Strumane, K, Chamuleau, M E D, Mutis, T, De Jong, R N, Schuurman, J, Breij, E C W, Beurskens, F J, Parren, P W H I & Taylor, R P 2019, ' CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering ', Haematologica, vol. 104, no. 9, pp. 1841-1852 . https://doi.org/10.3324/haematol.2018.207266
CD20 monoclonal antibody therapies have significantly improved the outlook for patients with B-cell malignancies. However, many patients acquire resistance, demonstrating the need for new and improved drugs. We previously demonstrated that the natura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43035da1f43e3f084bfdb3c5b9d915b0
https://hdl.handle.net/1887/121519
https://hdl.handle.net/1887/121519