Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Rob Moccia"'
Autor:
Yaa Ababio, Scott P. Kelly, Franca S Angeli, Joanne Berghout, Kui Huang, Kathy Liu, Sara Burns, Cynthia Senerchia, Rob Moccia, Gabriel C. Brooks
Publikováno v:
American Journal of Medicine Open, Vol 10, Iss , Pp 100038- (2023)
Background: Dilated cardiomyopathy (DCM) contributes significantly to heart failure prevalence, yet supporting epidemiologic data is sparse. This study sought to estimate the period prevalence of DCM and the proportion of idiopathic DCM in the United
Externí odkaz:
https://doaj.org/article/6d203e22dd34425cbe092f4429a9a700
Autor:
Daniel A. Mordes, Mercedes Prudencio, Lindsey D. Goodman, Joseph R. Klim, Rob Moccia, Francesco Limone, Olli Pietilainen, Kaitavjeet Chowdhary, Dennis W. Dickson, Rosa Rademakers, Nancy M. Bonini, Leonard Petrucelli, Kevin Eggan
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-13 (2018)
Abstract A hexanucleotide (GGGGCC) repeat expansion in C9ORF72 is the most common genetic contributor to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Reduced expression of the C9ORF72 gene product has been propose
Externí odkaz:
https://doaj.org/article/7dff6ba8c98d431088d6dde5e87fa681
Autor:
Ryan M. Esquejo, Christopher T. Salatto, Jake Delmore, Bina Albuquerque, Allan Reyes, Yuji Shi, Rob Moccia, Emily Cokorinos, Matthew Peloquin, Mara Monetti, Jason Barricklow, Eliza Bollinger, Brennan K. Smith, Emily A. Day, Chuong Nguyen, Kieran F. Geoghegan, John M. Kreeger, Alan Opsahl, Jessica Ward, Amit S. Kalgutkar, David Tess, Lynne Butler, Norimitsu Shirai, Timothy F. Osborne, Gregory R. Steinberg, Morris J. Birnbaum, Kimberly O. Cameron, Russell A. Miller
Publikováno v:
EBioMedicine, Vol 31, Iss , Pp 122-132 (2018)
Dysregulation of hepatic lipid and cholesterol metabolism is a significant contributor to cardiometabolic health, resulting in excessive liver lipid accumulation and ultimately non-alcoholic steatohepatitis (NASH). Therapeutic activators of the AMP-A
Externí odkaz:
https://doaj.org/article/3a6b1a8ecd964eee8550aafb2b27ef05
Autor:
Jessica Ward, Jason Barricklow, Chuong Nguyen, Eliza Bollinger, Christopher T. Salatto, Bina Albuquerque, Mara Monetti, Norimitsu Shirai, Emily A. Day, Emily Cokorinos, Kieran F. Geoghegan, Gregory R. Steinberg, Rob Moccia, Matthew Peloquin, Ryan M. Esquejo, Morris J. Birnbaum, Russell A. Miller, Alan C. Opsahl, Brennan K. Smith, Jake Delmore, Kimberly O. Cameron, Timothy F. Osborne, Allan R. Reyes, John M. Kreeger, Lynne Butler, David A. Tess, Amit S. Kalgutkar, Yuji Shi
Publikováno v:
EBioMedicine, Vol 31, Iss, Pp 122-132 (2018)
EBioMedicine
EBioMedicine
Dysregulation of hepatic lipid and cholesterol metabolism is a significant contributor to cardiometabolic health, resulting in excessive liver lipid accumulation and ultimately non-alcoholic steatohepatitis (NASH). Therapeutic activators of the AMP-A
ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair
Autor:
Francesco Limone, Rob Moccia, Rory Kirchner, Kuchuan Chen, Kevin Eggan, Michael J. Steinbaugh, Brandi N. Davis-Dusenbery, Seth H. Cassel, Joseph R. Klim, Luis A. Williams, Irune Guerra San Juan, Daniel A. Mordes, Aaron Burberry, Clifford J. Woolf, Brian J. Wainger, Kanchana K. Gamage
Publikováno v:
Klim, J R, Williams, L A, Limone, F, Guerra San Juan, I, Davis-Dusenbery, B N, Mordes, D A, Burberry, A, Steinbaugh, M J, Gamage, K K, Kirchner, R, Moccia, R, Cassel, S H, Chen, K, Wainger, B J, Woolf, C J & Eggan, K 2019, ' ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair ', Nature Neuroscience, vol. 22, no. 2, pp. 167-179 . https://doi.org/10.1038/s41593-018-0300-4
Nature neuroscience
Nature Neuroscience, 22(2), 167-179. Nature Publishing Group
Nature neuroscience
Nature Neuroscience, 22(2), 167-179. Nature Publishing Group
The findings that amyotrophic lateral sclerosis (ALS) patients almost universally display pathological mislocalization of the RNA-binding protein TDP-43 and that mutations in its gene cause familial ALS have nominated altered RNA metabolism as a dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7575201e49e0ff4596695d193c6efb9
https://research.vu.nl/en/publications/51f18049-c86d-4095-bd7e-4bb042cdac0e
https://research.vu.nl/en/publications/51f18049-c86d-4095-bd7e-4bb042cdac0e
Autor:
Olli Pietilainen, Rosa Rademakers, Dennis W. Dickson, Nancy M. Bonini, Lindsey D. Goodman, Kaitavjeet Chowdhary, Leonard Petrucelli, Joseph R. Klim, Mercedes Prudencio, Daniel A. Mordes, Francesco Limone, Rob Moccia, Kevin Eggan
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-13 (2018)
Acta Neuropathologica Communications
Acta neuropathologica communications
Acta Neuropathologica Communications
Acta neuropathologica communications
A hexanucleotide (GGGGCC) repeat expansion in C9ORF72 is the most common genetic contributor to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Reduced expression of the C9ORF72 gene product has been proposed as a po
Autor:
Florian T. Merkle, Sulagna Ghosh, Aaron Burberry, Derrick J. Rossi, Kevin Eggan, Luigi D. Notarangelo, Quan Zhen Li, Leonard I. Zon, Kathryn Koszka, Rob Moccia, Morag Stewart, Daniel A. Mordes, Ajay K. Singh, Jennifer J. Trowbridge, Naoki Suzuki, Satomi Suzuki-Uematsu, Jin Yuan Wang
C9ORF72 mutations are found in a significant fraction of patients suffering from amyotrophic lateral sclerosis and frontotemporal dementia, yet the function of the C9ORF72 gene product remains poorly understood. We show that mice harboring loss-of-fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2533368df9ece7a585df9394ac44fc1
https://www.repository.cam.ac.uk/handle/1810/296398
https://www.repository.cam.ac.uk/handle/1810/296398
Autor:
Clifford J. Woolf, James Nemesh, Sebastian Thams, Morgan L. Maeder, Derek H. Oakley, Steven A. McCarroll, Florian T. Merkle, Michael J. Ziller, Robert H. Brown, Kevin Eggan, Gabriella L. Boulting, Brian J. Wainger, Steve S.W. Han, Justin K. Ichida, Luis A. Williams, Rob Moccia, Nick Atwater, Jackson Sandoe, Robert E. Handsaker, Theodore Peng, Shravani Mikkilineni, Evangelos Kiskinis, J. Keith Joung, Scott Noggle, Daniel Paull, Cassidy Mellin, Mathew J. Goodwin, Stefania Di Costanzo, Brandi N. Davis-Dusenbery
Publikováno v:
Cell Stem Cell. 14(6)
SummaryAlthough many distinct mutations in a variety of genes are known to cause Amyotrophic Lateral Sclerosis (ALS), it remains poorly understood how they selectively impact motor neuron biology and whether they converge on common pathways to cause
Autor:
Rob Moccia, Atsushi Intoh, Kevin Eggan, Ian Armstrong, Brandi N. Davis-Dusenbery, Naoki Suzuki, Florian T. Merkle, Kathryn Koszka, Asif M. Maroof
Publikováno v:
Nature neuroscience
Using transgenic mice harboring a targeted LacZ insertion, we studied the expression pattern of the C9ORF72 mouse ortholog (3110043O21Rik). Unlike most genes that are mutated in amyotrophic lateral sclerosis (ALS), which are ubiquitously expressed, t
Publikováno v:
Gastroenterology. 118:A596