Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Rob Michalides"'
Publikováno v:
International Journal of Breast Cancer, Vol 2011 (2011)
About two thirds of all human breast cancer cases are estrogen receptor positive. The drug of first choice for these patients is tamoxifen. However, about half of the recurrences after removal of the primary tumor are or become resistant to this drug
Externí odkaz:
https://doaj.org/article/cf5393191de44dbb96c24cd5fff3af3f
Autor:
C Bentin Toaldo, Sander Canisius, Xanthippi Alexi, Jacques Neefjes, R de Leeuw, Rob Michalides, Koen D. Flach, Wilbert Zwart
Publikováno v:
Oncogene. 32:3543-3551
Protein kinase A (PKA)-induced estrogen receptor alpha (ERα) phosphorylation at serine residue 305 (ERαS305-P) can induce tamoxifen (TAM) resistance in breast cancer. How this phospho-modification affects ERα specificity and translates into TAM re
Autor:
Michael Hauptmann, Rob Michalides, Caroline Holm-Wigerup, Olle Stål, Sabine C. Linn, Göran Landberg, Marleen Kok
Publikováno v:
JNCI: Journal of the National Cancer Institute. 101:1725-1729
Although estrogen receptor-alpha (ER) [corrected] is a marker used to identify breast cancer patients most likely to benefit from endocrine therapy, approximately 50% of ER-positive [corrected] breast carcinomas are resistant to tamoxifen. Preclinica
Autor:
Mariska Rondaij, Jacques Neefjes, Wilbert Zwart, Rob Michalides, Z. Dave Sharp, Michael A. Mancini, Kees Jalink
Publikováno v:
Molecular Endocrinology. 23:1335-1345
Resistance to tamoxifen treatment occurs in approximately 50% of the estrogen receptor (ER)α-positive breast cancer patients. Resistant patients would benefit from treatment with other available antiestrogens. Arzoxifene is an effective growth inhib
Publikováno v:
Chemistry & Biology, 16(7), 702-711. Cell Press
The interaction of estrogen receptor alpha (ERalpha) with the consensus LXXLL motifs of transcriptional coactivators provides an entry for functional ERalpha inhibition. Here, synthetic cell-permeable LXXLL peptide probes are brought forward that all
Autor:
Cristiane Bentin Toaldo, Michael Hauptmann, Jacques Neefjes, Maurice P.H.M. Jansen, Karin Beelen, Els M.J.J. Berns, Marleen Kok, Sabine C. Linn, Xanthippi Alexi, Rob Michalides, Wilbert Zwart
Publikováno v:
BMC Cancer
BMC Cancer, 15:588. BioMed Central Ltd.
BMC Cancer, 15:588. BioMed Central Ltd.
Background Estrogen Receptor alpha (ERα)-positive breast cancer patients receive endocrine therapy, often in the form of tamoxifen. However, resistance to tamoxifen is frequently observed. A signalling cascade that leads to tamoxifen resistance is d
Autor:
Alexander Griekspoor, Jacques Neefjes, Astrid Balkenende, Laura van 't Veer, Arno Velds, Rob Michalides, Kees Jalink, Lennert Janssen, Desiree Verwoerd, Arno Floore
Publikováno v:
Cancer Cell. 5(6):597-605
Using a novel approach that detects changes in the conformation of ERalpha, we studied the efficacy of anti-estrogens to inactivate ERalpha under different experimental conditions. We show that phosphorylation of serine-305 in the hinge region of ERa
Publikováno v:
Breast Cancer Research and Treatment. 74:55-63
Treatment of MCF7 human breast cancer cells with taxol induces G2/M arrest followed by mitotic death. A moderate overexpression of ectopic cyclin D1 accelerated these G2/M associated events and resulted in a reduced clonogenic survival upon taxol tre
Publikováno v:
Head & Neck. 24:694-704
Tumors gradually develop as a result of a multistep acquisition of genetic alterations and ultimately emerge as selfish, intruding and metastatic cells. The genetic defects associated with the process of tumor progression affect control of proliferat
Autor:
Ed Schuuring, Herbert Brok, Henk van Damme, Erik Geelen, Carla J. de Boer, E. Verhoeven, Philip M. Kluin, Ellen Schuuring-Scholtes, Rob Michalides, Vera Van Buuren
Publikováno v:
Cell Adhesion and Communication. 6:185-209
We have identified a novel gene, EMS1, that is consistently amplified and overexpressed in human carcinomas with an amplification of the chromosome 11q13 region. Comparisons of the EMS1 sequences with those present in the GenBank databases revealed a