Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Rob Meijers"'
Autor:
Clement E. Blanchet, Adam Round, Haydyn D. T. Mertens, Kartik Ayyer, Melissa Graewert, Salah Awel, Daniel Franke, Katerina Dörner, Saša Bajt, Richard Bean, Tânia F. Custódio, Raphael de Wijn, E. Juncheng, Alessandra Henkel, Andrey Gruzinov, Cy M. Jeffries, Yoonhee Kim, Henry Kirkwood, Marco Kloos, Juraj Knoška, Jayanath Koliyadu, Romain Letrun, Christian Löw, Jana Makroczyova, Abhishek Mall, Rob Meijers, Gisel Esperanza Pena Murillo, Dominik Oberthür, Ekaterina Round, Carolin Seuring, Marcin Sikorski, Patrik Vagovic, Joana Valerio, Tamme Wollweber, Yulong Zhuang, Joachim Schulz, Heinrich Haas, Henry N. Chapman, Adrian P. Mancuso, Dmitri Svergun
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Free-electron lasers (FEL) are revolutionizing X-ray-based structural biology methods. While protein crystallography is already routinely performed at FELs, Small Angle X-ray Scattering (SAXS) studies of biological macromolecules are not as
Externí odkaz:
https://doaj.org/article/bcf514c39af3436883cc2c8e5bf81aab
Autor:
Yuxin Hao, Jiabin Yan, Courtney Fraser, Aiping Jiang, Murali Anuganti, Roushu Zhang, Kenneth Lloyd, Joseph Jardine, Jessica Coppola, Rob Meijers, Jing Li, Timothy A. Springer
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Integrins are cell surface receptors that mediate the interactions of cells with their surroundings and play essential roles in cell adhesion, migration, and homeostasis. Eight of the 24 integrins bind to the tripeptide Arg-Gly-Asp (RGD) motif in the
Externí odkaz:
https://doaj.org/article/cf98f9e736e742c0b512e4f1ef781a2c
Autor:
Raghavendra Anjanappa, Maria Garcia-Alai, Janine-Denise Kopicki, Julia Lockhauserbäumer, Mohamed Aboelmagd, Janina Hinrichs, Ioana Maria Nemtanu, Charlotte Uetrecht, Martin Zacharias, Sebastian Springer, Rob Meijers
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Major Histocompatibility Complex (MHC) class I molecules present tightly binding peptides on the cell surface for recognition by cytotoxic T cells. Here, the authors present the crystal structures of a disulfide-stabilized human MHC class I molecule
Externí odkaz:
https://doaj.org/article/0a9d6a6f48e3448e84d9257ff4977dbc
Autor:
Maria M. Garcia-Alai, Johannes Heidemann, Michal Skruzny, Anna Gieras, Haydyn D. T. Mertens, Dmitri I. Svergun, Marko Kaksonen, Charlotte Uetrecht, Rob Meijers
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Adapter proteins assist clathrin coated pit assembly. Here, the authors combine native mass spectrometry, crystallography and SAXS measurements and show that the membrane–proximal domains of the adaptor proteins epsin and Sla2 form complexes mediat
Externí odkaz:
https://doaj.org/article/3b231f81fed242b185fa1a34c644ce5f
Autor:
Lorenzo I. Finci, Jie Zhang, Xiaqin Sun, Robert G. Smock, Rob Meijers, Yan Zhang, Junyu Xiao, Jia-huai Wang
Publikováno v:
Protein & Cell, Vol 8, Iss 9, Pp 701-705 (2017)
Externí odkaz:
https://doaj.org/article/4af7869e11eb4238be0043bd72b4a011
Autor:
Robert G. Smock, Rob Meijers
Publikováno v:
Open Biology, Vol 8, Iss 10 (2018)
Glycosaminoglycans (GAGs) play a widespread role in embryonic development, as deletion of enzymes that contribute to GAG synthesis lead to deficiencies in cell migration and tissue modelling. Despite the biochemical and structural characterization of
Externí odkaz:
https://doaj.org/article/54672c2d76f94f1b8ffa0ee33a358eb7
Autor:
Matthew Dunne, Haydyn D T Mertens, Vasiliki Garefalaki, Cy M Jeffries, Andrew Thompson, Edward A Lemke, Dmitri I Svergun, Melinda J Mayer, Arjan Narbad, Rob Meijers
Publikováno v:
PLoS Pathogens, Vol 10, Iss 7, p e1004228 (2014)
The bacteriophage ΦCD27 is capable of lysing Clostridium difficile, a pathogenic bacterium that is a major cause for nosocomial infection. A recombinant CD27L endolysin lyses C. difficile in vitro, and represents a promising alternative as a bacteri
Externí odkaz:
https://doaj.org/article/76e1091774d84f3ca598478c1eec7367
Autor:
Trisha Gura, Amparo Acker-Palmer, Alex Kolodkin, Rob Meijers, Naoko Mizuno, Elena Seiradake, Marc Tessier-Lavigne
Publikováno v:
Neuron. 110:3656-3660
Treg cells drive MYCN-mediated immunosuppression and tumor aggressiveness in high-risk neuroblastoma
Autor:
Xiaodan Qin, Andrew Lam, Xu Zhang, Satyaki Sengupta, J. Bryan Iorgulescu, Tao Zuo, Alexander E. Floru, Grace Meara, Liang Lin, Kenneth Lloyd, Lauren Kwok, Kaylee Smith, Raghavendar T. Nagaraju, Rob Meijers, Craig Ceol, Ching-Ti Liu, Sanda Alexandrescu, Catherine J. Wu, Derin B. Keskin, Rani E. George, Hui Feng
Solid tumors, especially those with aberrant MYCN activation, harbor an immunosuppressive microenvironment to fuel malignant growth and trigger treatment resistance1,2, yet the underlying mechanisms are elusive and effective strategies to tackle this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c63883130467fe2677d688fca7628f12
https://doi.org/10.1101/2022.10.03.510561
https://doi.org/10.1101/2022.10.03.510561
Autor:
Julia Lockhauserbäumer, Maria Garcia-Alai, Ioana Maria Nemtanu, Janine-Denise Kopicki, Mohamed Aboelmagd, Raghavendra Anjanappa, Sebastian Springer, Charlotte Uetrecht, Janina Hinrichs, Martin Zacharias, Rob Meijers
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications 11(1), 1314 (1-11) (2020). doi:10.1038/s41467-020-14862-4
Nature Communications
Nature Communications 11(1), 1314 (1-11) (2020). doi:10.1038/s41467-020-14862-4
Nature Communications
Major Histocompatibility Complex (MHC) class I molecules selectively bind peptides for presentation to cytotoxic T cells. The peptide-free state of these molecules is not well understood. Here, we characterize a disulfide-stabilized version of the hu