Zobrazeno 1 - 10
of 385
pro vyhledávání: '"Rob M J, Liskamp"'
Publikováno v:
Viruses, Vol 13, Iss 2, p 326 (2021)
Hepatitis C virus remains a global threat, despite the availability of highly effective direct-acting antiviral (DAA) drugs. With thousands of new infections annually, the need for a prophylactic vaccine is evident. However, traditional vaccine desig
Externí odkaz:
https://doaj.org/article/1792635458dd4bd2a041df013de03cde
Autor:
Maarten Honing, Darya Hadavi, Matt Timmers, Tommi Meulemans, Jimmy Weterings, Rob M. J. Liskamp, Cristianne J.F. Rijcken, Harald Veldhuis, Hans Ippel
Publikováno v:
Chemical Science
Chemical Science, 11(33), 9011-9016. Royal Society of Chemistry
Chemical Science, 11(33), 9011-9016. Royal Society of Chemistry
We describe the development of TMTH-SulfoxImine (TMTHSI) as a superior click reagent. This reagent combines a great reactivity, with small size and low hydrophobicity and compares outstandingly with existing click reagents. TMTHSI can be conveniently
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:2857-2870
The development of a new class of cysteine protease inhibitors utilising the thiosulfonate moiety as an SH specific electrophile is described. This moiety has been introduced into suitable amino acid derived building blocks, which were incorporated i
Autor:
Frederike M. Müskens, Andrew B. Tobin, Richard J. Ward, Dominik Herkt, Graeme Milligan, Helmus van de Langemheen, Rob M. J. Liskamp
Publikováno v:
Molecular Pharmacology
Chemoproteomic approaches to identify ligand-receptor interactions have gained popularity. However, identifying transmembrane receptors remains challenging. A new trifunctional probe to aid the nonbiased identification of such receptors was developed
Autor:
Gemma González-Ortiz, Sílvia Bronsoms, H C Quarles Van Ufford, S Bart A Halkes, Ritva Virkola, Rob M J Liskamp, Cees J Beukelman, Roland J Pieters, José Francisco Pérez, Susana María Martín-Orúe
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104258 (2014)
Wheat bran (WB) from Triticum aestivum has many beneficial effects on human health. To the best of our knowledge, very little has been published about its ability to prevent pathogenic bacterial adhesion in the intestine. Here, a WB extract was fract
Externí odkaz:
https://doaj.org/article/fe273cc5583e421da1eeb8d45acc3aba
Autor:
Alison M. Michie, Xu Huang, David Vetrie, Laura Monaghan, Alex Hoose, Niamh Mannion, Roderick P. Bunschoten, Matthew E. Massett, Shaun David Patterson, Rob M. J. Liskamp, Sandra Marmiroli, Heather G. Jørgensen
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-16 (2021)
Cell Death & Disease
Cell Death & Disease
Epigenomic dysregulation is a common pathological feature in human hematological malignancies. H3K9me3 emerges as an important epigenomic marker in acute myeloid leukemia (AML). Its associated methyltransferases, such as SETDB1, suppress AML leukemog
Publikováno v:
Viruses
Viruses, Vol 13, Iss 326, p 326 (2021)
Volume 13
Issue 2
Viruses, Vol 13, Iss 326, p 326 (2021)
Volume 13
Issue 2
Hepatitis C virus remains a global threat, despite the availability of highly effective direct-acting antiviral (DAA) drugs. With thousands of new infections annually, the need for a prophylactic vaccine is evident. However, traditional vaccine desig
Publikováno v:
Journal of Peptide Science
In this research we describe the improvement of the water-solubility of cyclic epitope mimics based on the HCV E2 glycoprotein by incorporation of suitable polar hinges. The poor solubility of epitope mimics based on peptide sequences in the envelope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c45096fc2522189e498d3d12dc0d66c4
https://eprints.gla.ac.uk/197072/7/197072.pdf
https://eprints.gla.ac.uk/197072/7/197072.pdf
Synthesis and cellular penetration properties of new phosphonium based cationic amphiphilic peptides
Autor:
Rob M. J. Liskamp, Carol-Anne Smith, Mathis O. Riehle, Mohammed Hezwani, Tobias M. Postma, Susan Gannon, Alin Pirvan, Ezequiel Silva Nigenda
Publikováno v:
MedChemComm. 9:982-987
A new category of phosphonium based cationic amphiphilic peptides has been developed and evaluated as potential antimicrobial peptides and cell penetrating peptides. The required building blocks were conveniently accessible from cysteine and could be
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:5055-5063
Peptido sulfonyl fluoride derivatives were designed and synthesized containing a substituent on the alpha position (αPSFs) with respect to the sulfonyl fluoride electrophilic trap. The chemical reactivity of these α-substituted amino sulfonyl fluor