Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Rob L Hopfner"'
Publikováno v:
Cardiovascular Research. 45:994-1000
Objective: Earlier, we reported that high insulin incubation in vitro leads to increased ETA receptor expression in cultured rat aortic smooth muscle cells (Diabetes 1998, 47: 934–944). Our later observation of enhanced endothelin-1 evoked vasocons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc5a3e5ca4983c1b5b4bbc70d0b39ba
https://doi.org/10.1016/s0008-6363(99)00417-4
https://doi.org/10.1016/s0008-6363(99)00417-4
Autor:
Venkat Gopalakrishnan, Rob L Hopfner
Publikováno v:
Diabetologia. 42:1383-1394
Since the discovery of endothelin-1 as the most potent endothelial-derived vasoconstrictor/mitogenic peptide a decade ago, considerable evidence has implicated this peptide in various cardiovascular disease states, including diabetes mellitus. Plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153019162061deb149a06180aa016715
https://doi.org/10.1007/s001250051308
https://doi.org/10.1007/s001250051308
Publikováno v:
Journal of Cardiovascular Pharmacology. 34:540-546
The presence of arginine vasopressin (AVP) V1 receptors on neonatal rat cardiomyocytes (NRCs) linked to processes capable of elevating intracellular free calcium ([Ca2+]i) is now firmly established. This study examined the sources and signaling invol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2e156b2f42c11bac1bc6f6837043b3f
https://doi.org/10.1097/00005344-199910000-00010
https://doi.org/10.1097/00005344-199910000-00010
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1440:89-99
Phosphatidic acid (PA), which can be synthesized de novo, or as a product of phosphatidylcholine hydrolysis and/or phosphorylation of 1,2-diacylglycerol (DAG), mediates diverse cellular functions in various cell types, including cardiomyocytes. We se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::504a077cc7a85393b1c15bebf359cbe9
https://doi.org/10.1016/s1388-1981(99)00115-8
https://doi.org/10.1016/s1388-1981(99)00115-8
Publikováno v:
Biochemical Pharmacology. 58:177-182
The direct vascular effect of pneumadin (PN) was determined by studying the changes in intracellular free calcium ([Ca 2+ ] i ) levels in cultured rat aortic smooth muscle cells maintained between the second and fifth passages. PN evoked a rapid, con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dda611f0891287fba1e120d5ed792ad
https://doi.org/10.1016/s0006-2952(99)00071-4
https://doi.org/10.1016/s0006-2952(99)00071-4
Publikováno v:
European Journal of Pharmacology. 374:221-227
While alterations in the release and action of endothelial derived vasoactive factors such as endothelin-1 and endothelial derived relaxing factor (EDRF) occur in diabetes mellitus, the nature and direction of these changes is controversial. We exami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc3fce864f4e96272f1be2c80f0a3396
https://doi.org/10.1016/s0014-2999(99)00316-7
https://doi.org/10.1016/s0014-2999(99)00316-7
Publikováno v:
Molecular and Cellular Biochemistry. 195:183-190
Arginine vasopressin (AVP) has been shown to promote vascular smooth muscle cell hypertrophy and hyperplasia of fibroblasts. The present study examines the effect of AVP and endothelin-1 (ET-1) on protein, DNA, and RNA synthesis in primary cultures o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91ae0044eaa89ed80e92fd393f36e9a2
https://doi.org/10.1023/a:1006961330375
https://doi.org/10.1023/a:1006961330375
Publikováno v:
Diabetologia. 41:1233-1240
Although insulin has been shown to raise plasma concentrations of endothelin (ET) and up regulate vascular smooth muscle ETA receptor expression, the interaction of vanadate, an insulinomimetic agent, with the vascular ET system has not been investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36195d3fcc37d05734ed9a3eafb3a71d
https://doi.org/10.1007/s001250051057
https://doi.org/10.1007/s001250051057
Publikováno v:
Diabetes. 47:937-944
While insulin is known to promote vascular smooth muscle (VSM) relaxation, it also enhances endothelin-1 (ET-1) secretion and action in conditions such as NIDDM and hypertension. We examined the effect of insulin pretreatment on intracellular free ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe54d2316fbd8822b1dd6ddf8c34d527
https://doi.org/10.2337/diabetes.47.6.937
https://doi.org/10.2337/diabetes.47.6.937
Publikováno v:
Journal of Cardiovascular Pharmacology. 31:S196-S198
The effects of insulin (10 nM) and sodium orthovanadate (SOV, 25 μM) pretreatment for 24 h on endothelin-l (ET-1) and IRL-1620 (ET B agonist)-evoked increases in intracellular free calcium levels [Ca 2+ ] i were determined by fura-2 fluorescence met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd7c50908bb2a93718e61bbae84e559d
https://doi.org/10.1097/00005344-199800001-00055
https://doi.org/10.1097/00005344-199800001-00055