Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Rob Klompmaker"'
Autor:
Indra A. Shaltiel, Alba Llopis, Melinda Aprelia, Rob Klompmaker, Apostolos Menegakis, Lenno Krenning, René H. Medema
Publikováno v:
Cells, Vol 10, Iss 3, p 550 (2021)
Most Cyclin-dependent kinases (Cdks) are redundant for normal cell division. Here we tested whether these redundancies are maintained during cell cycle recovery after a DNA damage-induced arrest in G1. Using non-transformed RPE-1 cells, we find that
Externí odkaz:
https://doaj.org/article/6239935eb2eb4a59bf037fae1993f10b
Resistance of Hypoxic Cells to Ionizing Radiation Is Mediated in Part via Hypoxia-Induced Quiescence
Autor:
Apostolos Menegakis, Rob Klompmaker, Claire Vennin, Aina Arbusà, Maartje Damen, Bram van den Broek, Daniel Zips, Jacco van Rheenen, Lenno Krenning, René H. Medema
Publikováno v:
Cells, Vol 10, Iss 3, p 610 (2021)
Double strand breaks (DSBs) are highly toxic to a cell, a property that is exploited in radiation therapy. A critical component for the damage induction is cellular oxygen, making hypoxic tumor areas refractory to the efficacy of radiation treatment.
Externí odkaz:
https://doaj.org/article/0ffcea6ba4064bcd9c28c49c6cecd2db
Resistance of Hypoxic Cells to Ionizing Radiation Is Mediated in Part via Hypoxia-Induced Quiescence
Autor:
Rob Klompmaker, Claire Vennin, Bram van den Broek, Aina Arbusà, Jacco van Rheenen, Maartje P F Damen, Daniel Zips, René H. Medema, Apostolos Menegakis, Lenno Krenning
Publikováno v:
Cells; Volume 10; Issue 3; Pages: 610
Cells, Vol 10, Iss 610, p 610 (2021)
Cells
Cells, Vol 10, Iss 610, p 610 (2021)
Cells
Double strand breaks (DSBs) are highly toxic to a cell, a property that is exploited in radiation therapy. A critical component for the damage induction is cellular oxygen, making hypoxic tumor areas refractory to the efficacy of radiation treatment.
Autor:
Rob Klompmaker, Alba Llopis, Lenno Krenning, Apostolos Menegakis, René H. Medema, Indra A. Shaltiel, Melinda Aprelia
Publikováno v:
Cells
Volume 10
Issue 3
Cells, Vol 10, Iss 550, p 550 (2021)
Volume 10
Issue 3
Cells, Vol 10, Iss 550, p 550 (2021)
Most Cyclin-dependent kinases (Cdks) are redundant for normal cell division. Here we tested whether these redundancies are maintained during cell cycle recovery after a DNA damage-induced arrest in G1. Using non-transformed RPE-1 cells, we find that
Autor:
Femke M. Feringa, Anna G. Manjón, Yongsoo Kim, Wilbert Zwart, Jeroen van den Berg, Lenno Krenning, Bram van den Broek, Lisa Koob, Kees Jalink, René H. Medema, Stacey E. P. Joosten, Rob Klompmaker
The authors have withdrawn their manuscript whilst they perform additional experiments to test some of their conclusions further.Despite repetitive attempts to reproduce the data shown in figure 2I, we have failed to obtain convincing evidence that c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9d6a94fe201de1fd075928167cf095
Autor:
Martijn Gloerich, Rob Klompmaker, Wendy van Veelen, Ruud Berger, Dennis S. Acton, Cornelis J.M. Lips, René H. Medema, Jo W.M. Höppener, Eric Kalkhoven, Carola J.R. van Gasteren
Publikováno v:
International Journal of Cancer. 124:339-345
In multiple endocrine neoplasia syndrome Type 2 (MEN2), medullary thyroid carcinoma (MTC) and pheochromocytoma (PC) are associated with hereditary activating germ-line mutations in the RET proto-oncogene. Also in a large percentage of sporadic MTCs a
Autor:
Jero Calafat, Rob M. F. Wolthuis, René H. Medema, Hans Janssen, Rob Klompmaker, Barbara C. M. van de Weerdt, Gerben Vader, Marcel A. T. M. van Vugt
Publikováno v:
Journal of biological chemistry, 279(35), 36841. American society for biochemistry and molecular biology
Polo-like kinase-1 (Plk1) performs multiple essential functions during the cell cycle. Here we show that human Plk1-deficient cells are unable to separate their centrosomes, fail to form a bipolar spindle, and undergo a Mad2/BubR1-dependent prometaph
Autor:
Veronique A. J. Smits, Erich A. Nigg, René H. Medema, Lionel Arnaud, Gert Rijksen, Rob Klompmaker
Publikováno v:
Nature cell biology, 2(9), 672. Nature publishing group
Polo-like kinases (PLKs) have an important role in several stages of mitosis. They contribute to the activation of cyclin B/Cdc2 and are involved in centrosome maturation and bipolar spindle formation at the onset of mitosis1, 2. PLKs also control mi
Autor:
Marieke A.G. Essers, Gert Rijksen, Maartjie A. van Peer, Rob Klompmaker, Veronique A. J. Smits, René H. Medema
Publikováno v:
Journal of biological chemistry, 275(25), 19375. American society for biochemistry and molecular biology
Basic fibroblast growth factor (bFGF) has been shown to induce growth inhibition of the neuroepithelioma cell line SK-N-MC. Here we show that this growth inhibition occurs in G(2). We show that bFGF is active on these cells during S and early G(2) ph
Autor:
Ellen Wientjens, P. M. P. Kristel, Rob Michalides, B. Van Der Burg, Rob Klompmaker, Renate M. L. Zwijsen
Publikováno v:
Molecular and Cellular Biology. 16:2554-2560
Cyclin D1 controls G1-associated processes, including G0-to-G1 and G1-to-S transitions. This study demonstrates a novel aspect of cyclin D1 as a regulator of the transition between G1 and G0. Overexpression of cyclin D1 in MCF7 breast tumor cells res