Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Rob J W, Arts"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 515 (2023)
Anticytokine autoantibodies (ACAAs) are a fascinating group of antibodies that have gained more and more attention in the field of autoimmunity and secondary immunodeficiencies over the years. Some of these antibodies are characterized by their abili
Externí odkaz:
https://doaj.org/article/1da2412e772f435bb0bb52afcfba4197
Autor:
Dennis M. deGraaf, Lisa U. Teufel, Aline H. deNooijer, Adriaan J. vanGammeren, Antonius A. M. Ermens, Ildikó O. Gaál, Tania O. Crișan, Frank L. van deVeerdonk, Mihai G. Netea, Charles A. Dinarello, Leo A. B. Joosten, Rob J. W. Arts, the Radboudumc Center for Infectious Diseases COVID‐19 Study Group
Publikováno v:
Immunity, Inflammation and Disease, Vol 10, Iss 11, Pp n/a-n/a (2022)
Abstract Introduction A major contributor to coronavirus disease 2019 (COVID‐19) progression and severity is a dysregulated innate and adaptive immune response. Interleukin‐38 (IL−38) is an IL‐1 family member with broad anti‐inflammatory pr
Externí odkaz:
https://doaj.org/article/316ee342c38842a0b2005fa7521bb057
Autor:
Lisa U. Teufel, Dennis M. de Graaf, Mihai G. Netea, Charles A. Dinarello, Leo A. B. Joosten, Rob J. W. Arts
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Interleukin (IL)-38 is the latest discovered member of the interleukin-1 family, which has anti-inflammatory properties similar to IL-36Ra. Several studies compared circulating IL-38 concentrations in healthy and diseased populations to characterize
Externí odkaz:
https://doaj.org/article/86943f4fdc194ef38b8d75450095bfb1
Autor:
Lisa U. Teufel, Mihai G. Netea, Frank L. van de Veerdonk, Charles A. Dinarello, Leo A. B. Joosten, Rob J. W. Arts
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2311 (2023)
Trained immunity is the process of long-term functional reprogramming (a de facto innate immune memory) of innate immune cells such as monocytes and macrophages after an exposure to pathogens, vaccines, or their ligands. The induction of trained immu
Externí odkaz:
https://doaj.org/article/7e7e0957b6f04896a6c71e9c36dab38c
Autor:
Annelies Post, Berenger Kaboré, Mike Berendsen, Salou Diallo, Ousmane Traore, Rob J. W. Arts, Mihai G. Netea, Leo A. B. Joosten, Halidou Tinto, Jan Jacobs, Quirijn de Mast, André van der Ven
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
IntroductionPatients with clinical malaria have an increased risk for bacterial bloodstream infections. We hypothesized that asymptomatic malaria parasitemia increases susceptibility for bacterial infections through an effect on the innate immune sys
Externí odkaz:
https://doaj.org/article/e658f9f1a1fa422bafc72c1a994906b4
Autor:
Jona Walk, L. Charlotte J. de Bree, Wouter Graumans, Rianne Stoter, Geert-Jan van Gemert, Marga van de Vegte-Bolmer, Karina Teelen, Cornelus C. Hermsen, Rob J. W. Arts, Marije C. Behet, Farid Keramati, Simone J. C. F. M. Moorlag, Annie S. P. Yang, Reinout van Crevel, Peter Aaby, Quirijn de Mast, André J. A. M. van der Ven, Christine Stabell Benn, Mihai G. Netea, Robert W. Sauerwein
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Immune activation induces long-term alterations of setpoints, impacting responses to subsequent unrelated stimuli. Here the authors show that volunteers vaccinated with BCG respond to controlled human malaria infection with increased clinical symptom
Externí odkaz:
https://doaj.org/article/548440850a244fa5947c578ae0771c61
Autor:
Jona Walk, Farid Keramati, L. Charlotte J. de Bree, Rob J. W. Arts, Bas Blok, Mihai G. Netea, Hendrik G. Stunnenberg, Robert W. Sauerwein
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Innate immune memory responses (also termed “trained immunity”) have been described in monocytes after BCG vaccination and after stimulation in vitro with microbial and endogenous ligands such as LPS, β-glucan, oxidized LDL, and monosodium urate
Externí odkaz:
https://doaj.org/article/ddcae7fd4b7542da9b9a7fbeae4f466b
Autor:
Marcia A. Munoz, Julie Jurczyluk, Anna Simon, Pravin Hissaria, Rob J. W. Arts, David Coman, Christina Boros, Sam Mehr, Michael J. Rogers
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The rare autoinflammatory disease mevalonate kinase deficiency (MKD, which includes HIDS and mevalonic aciduria) is caused by recessive, pathogenic variants in the MVK gene encoding mevalonate kinase. Deficiency of this enzyme decreases the synthesis
Externí odkaz:
https://doaj.org/article/27842b62c9b644a9a479322c9f12f919
Autor:
Jorge Cime-Castillo, Rob J. W. Arts, Valeria Vargas-Ponce de León, Ramon Moreno-Torres, Salvador Hernández-Martínez, Benito Recio-Totoro, Fabiola Claudio-Piedras, Mihai G. Netea, Humberto Lanz-Mendoza
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Endoreplication is a cell cycle program in which cells replicate their genomes without undergoing mitosis and cytokinesis. For the normal development of many organisms (from fungi to humans) and the formation of their organs, endoreplication is indis
Externí odkaz:
https://doaj.org/article/cd85e1befcb24cfe9ce3f297386c12d3
Autor:
Rob J. W. Arts, Po-Kai Huang, De Yang, Leo A. B. Joosten, Jos W. M. van der Meer, Joost J. Oppenheim, Mihai G. Netea, Shih-Chin Cheng
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
High-mobility group nucleosome-binding protein 1 (HMGN1) functions as a non-histone chromatin-binding protein in the cell nucleus. However, extracellular HMGN1 acts as an endogenous danger-associated inflammatory mediator (also called alarmin). We de
Externí odkaz:
https://doaj.org/article/ad0f6edde30f47c6808b2f025226051c