Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Rob J Vreeken"'
Autor:
Yiyi Zhang, Eliseo Guallar, Elena Blasco-Colmenares, Amy C Harms, Rob J Vreeken, Thomas Hankemeier, Gordon F Tomaselli, Alan Cheng
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157035 (2016)
INTRODUCTION:Individuals with systolic heart failure are at risk of ventricular arrhythmias and all-cause mortality. Little is known regarding the mechanisms underlying these events. We sought to better understand if oxylipins, a diverse class of lip
Externí odkaz:
https://doaj.org/article/eafd27b0202b4bc89bd61b90552a75c5
Autor:
Hazrat Ali, Marco I Ries, Peter P Lankhorst, Rob A M van der Hoeven, Olaf L Schouten, Marek Noga, Thomas Hankemeier, Noël N M E van Peij, Roel A L Bovenberg, Rob J Vreeken, Arnold J M Driessen
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98212 (2014)
The filamentous fungus Penicillium chrysogenum harbors an astonishing variety of nonribosomal peptide synthetase genes, which encode proteins known to produce complex bioactive metabolites from simple building blocks. Here we report a novel non-canon
Externí odkaz:
https://doaj.org/article/6380c87e856c4595a25ae2fd2cea9b99
Autor:
Sylwia Kuc, Maria P H Koster, Jeroen L A Pennings, Thomas Hankemeier, Ruud Berger, Amy C Harms, Adrie D Dane, Peter C J I Schielen, Gerard H A Visser, Rob J Vreeken
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98540 (2014)
ObjectiveThe first aim was to investigate specific signature patterns of metabolites that are significantly altered in first-trimester serum of women who subsequently developed preeclampsia (PE) compared to healthy pregnancies. The second aim of this
Externí odkaz:
https://doaj.org/article/8c7e6bd7d40044c9992d2599546e2422
Autor:
Giuseppe Astarita, Jennifer H McKenzie, Bin Wang, Katrin Strassburg, Angela Doneanu, Jay Johnson, Andrew Baker, Thomas Hankemeier, James Murphy, Rob J Vreeken, James Langridge, Jing X Kang
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e96221 (2014)
A balanced omega-6/omega-3 polyunsaturated fatty acid (PUFA) ratio has been linked to health benefits and the prevention of many chronic diseases. Current dietary intervention studies with different sources of omega-3 fatty acids (omega-3) lack appro
Externí odkaz:
https://doaj.org/article/9816b672132b4ef1a7ee788d32022121
Autor:
Hazrat Ali, Marco I Ries, Jeroen G Nijland, Peter P Lankhorst, Thomas Hankemeier, Roel A L Bovenberg, Rob J Vreeken, Arnold J M Driessen
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65328 (2013)
Profiling and structural elucidation of secondary metabolites produced by the filamentous fungus Penicillium chrysogenum and derived deletion strains were used to identify the various metabolites and enzymatic steps belonging to the roquefortine/mele
Externí odkaz:
https://doaj.org/article/7aed8595914d4172a0f0c8c1be077f65
Autor:
Deborah Dhuyvetter, Fetene Tekle, Maxim Nazarov, Rob J. Vreeken, Herman Borghys, Frederik Rombouts, Ilse Lenaerts, Astrid Bottelbergs
Publikováno v:
Drug Delivery, Vol 27, Iss 1, Pp 1597-1607 (2020)
The blood–brain barrier (BBB) is often a limiting factor for getting drugs in the brain. Bypassing the BBB by intranasal (IN), or also called nose to brain (NTB), route is an interesting and frequently investigated concept for brain drug delivery.
Externí odkaz:
https://doaj.org/article/3a2c73fb65e34179bd76465154cdf0e3
Autor:
Lieke Lamont, Darya Hadavi, Andrew P. Bowman, Bryn Flinders, Dale Cooper‐Shepherd, Martin Palmer, Jan Jordens, Ynze Mengerink, Maarten Honing, James Langridge, Tiffany Porta Siegel, Rob J. Vreeken, Ron M. A. Heeren
Publikováno v:
Rapid Communications in Mass Spectrometry, 37(5):e9439. Wiley
RATIONALE: Isomeric separation of prostanoids is often a challenge and requires chromatography and time-consuming sample preparation. Multiple prostanoid isomers have distinct in vivo functions crucial to understand the inflammation process, includin
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 8, Pp 1772-1783 (2014)
An ultraperformance LC (UPLC) method for the separation of different lipid molecular species and lipid isomers using a stationary phase incorporating charged surface hybrid (CSH) technology is described. The resulting enhanced separation possibilitie
Externí odkaz:
https://doaj.org/article/31683a1a2a814abdb8e01880b42fbeb0
Autor:
Bryn Flinders, Tiffany Porta Siegel, Darya Hadavi, Brent Viehmann, Rob J. Vreeken, Ron M. A. Heeren, Lieke Lamont
Publikováno v:
Analytical and Bioanalytical Chemistry
Analytical and Bioanalytical Chemistry, 413(10), 2779-2791. Springer
Analytical and Bioanalytical Chemistry, 413(10), 2779-2791. Springer
Mass spectrometry imaging (MSI) provides insight into the molecular distribution of a broad range of compounds and, therefore, is frequently applied in the pharmaceutical industry. Pharmacokinetic and toxicological studies deploy MSI to localize pote
Autor:
Herman Borghys, Fetene Tekle, Astrid Bottelbergs, Deborah Dhuyvetter, Rob J. Vreeken, Maxim Nazarov, Ilse Lenaerts, Frederik J. R. Rombouts
Publikováno v:
Drug Delivery
article-version (VoR) Version of Record
Drug Delivery, Vol 27, Iss 1, Pp 1597-1607 (2020)
article-version (VoR) Version of Record
Drug Delivery, Vol 27, Iss 1, Pp 1597-1607 (2020)
The blood–brain barrier (BBB) is often a limiting factor for getting drugs in the brain. Bypassing the BBB by intranasal (IN), or also called nose to brain (NTB), route is an interesting and frequently investigated concept for brain drug delivery.